The study of UV-spectra of the sodium (3-oxo-3,4-dihydro-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetate


  • О. V. Kryvoshey Zaporizhzhia State Medical University,



Ultraviolet Spectrophotometry, Absorption, Electrons, Derivatives of [1, 2, 4]triazino[4, 3-c]quinazoline


Despite the potential of [1,2,4]triazino[4,3-c]quinazoline derivatives as promising bioactive compounds, their electronic spectra has not been studied. Present manuscript is aimed to the estimation of relationships of molecules structure with the nature of their UV-spectra and identifying spectral patterns of pharmacophore that determines the pharmacological activity of the substance. Mentioned  information undoubtedly contributes to the development of the theory of the purposeful synthesis of organic compounds.

Methods and results. UV-spectra of sodium (3-oxo-3,4-dihydro-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetate in different polarity solvents have been studied. It allowed to identify types of electron transitions, which were responsible of emergence of the observed absorption bands.

Conclusions. It was found that the UV-spectra of the studied compounds in solvents with different polarity were characterized by three absorption bands in the range 190–227 nm, 260–284 nm and 328–348 nm. According to Braude classification the first absorption band should be classified as 1La, the second – as 1Lb, and the third band is due to p-π- conjugation in the molecule of the whole molecule structure.


(2001). Derzhavna Farmakopeia Ukraiiny [State Pharmacopoeia of Ukraine]. Kharkiv: RIREH. [in Ukrainian].

Zakon Ukrainy Pro likarski zasoby : zi zminami vid 4 kvitnia 1996 roku №123/96-VR [Law of Ukraine «Drugs» №123/96-VR ]. Retrieved from [in Ukrainian].

Mashkovskij, M. D. (2010). Lekarstvennye sredstva [Drugs]. Moscow: Novaya volna. [in Russian].

Mejster, T. G. (1969). E′lektronnye spektry mnogoatomnyh molekul [Electronic spectroscopy of polyatomic molecules]. Leningrad: Izdatel'stvo Leningradskogo universiteta. [in Russian].

(2014) Derzhavnyi reiestr likarskykh zasobiv Ukrainy [State register of medicines Ukraine]. Retrieved from [in Ukrainian].

Reichardt, C. (1991). Rastvoriteli i e′ffekty sredy v organicheskoj khimii [Solvents and solvent effects in organic chemistry]. Moscow: Mir. [in Russian].

Kier, L. (2011). Molecular orbital studies in chemical pharmacology. New York: Academic Press.

Lantzke, I. R., Irish, D. E., & Gough, T. E. (1973). Spectroscopic Measurements. Covington, A. K. & Dickinson, T. Physical chemistry of organic solvent systems, (pp. 405–523). London: Plenum Press.

Lin, T. (1974). Quantum statistical calculation for correlation of biological activity and chemical structure. 1. Drug-receptor interactions. J. Med. Chem., 17(2), 151–154. doi 10.1021/jm00248a001.

Lothian, G. (1969). Absorbtion spectrophotometry. London: Hilger.

Thomas, M., & Ando, D. (1996). Ultraviolet and visible spectroscopy. Chichester: Wiley&Sons.

How to Cite

Kryvoshey ОV. The study of UV-spectra of the sodium (3-oxo-3,4-dihydro-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetate. CIPM [Internet]. 2016Mar.9 [cited 2023Dec.1];(1). Available from:



Analysis and standardization of biologycally active substances and dosage forms