Hemodynamics in experimental acute myocardial ischemia against the background of the use of substance PK-66 in comparison with the cordarone

Authors

  • O. V. Dzhygalyuk National Pirogov Memorial Medical University, Vinnytsya, Ukraine,
  • G. I. Stepaniuk National Pirogov Memorial Medical University, Vinnytsya, Ukraine,
  • D. A. Lysenko National Pirogov Memorial Medical University, Vinnytsya, Ukraine,

DOI:

https://doi.org/10.14739/2409-2932.2018.2.133510

Keywords:

myocardial ischemia, hemodynamics, substance PK-66, cordarone

Abstract

The aim of the study was to study the effect of PK-66 substances on hemodynamic parameters under experimental acute myocardial ischemia compared with cordarone.

Materials and methods. The experiments were carried out on 21 rabbits of the chinchilla breed. Acute myocardial ischemia (AMI) was modeled by intravenous injection of epinephrine at a dose of 0.2 mg / kg and caffeine sodium benzoate at a dose of 25 mg / kg. In the studies carried out, the Cordarone compounds and the PC-66 test sample were used. The maximum pressure in the left ventricle (MPLV), mean arterial pressure (MAP), total peripheral vascular resistance (TPVR), and minute volume (MV) were recorded. The initial values of the parameters studied were recorded immediately after the administration and after 30 minutes. after administration of the test substance, immediately after the introduction of the analyzers, and also after 15 and 30 minutes. after modeling pathology.

Results Simulation of AMI in rabbits, accompanied by a decrease in MV, caused by a decrease in contractile activity of the myocardium, also showed a simultaneous decrease MPLV in and a significant increase in TPVR, which is caused by a sudden decrease in MV and a decrease in MAP. The introduction of cordarone reduces the changes observed in the modeling of pathology (6.33–10.36 %). The use of PK-66 neutralizes changes in maximum pressure in the left ventricle observed immediately after modeling AMI, followed by a decrease in this parameter after 15 minutes. and normalization after 30 minutes. The prophylactic administration of the PK-66 test sample did not significantly influence the modeling of AMI. Substance PK-66 and cordarone showed a close unidirectional effect in AMI, reducing the changes in SAT, MPLV, MAP, and TPVR in pathology.

Conclusions. Acute ischemia of the myocardium in rabbits is characterized by an increase: total peripheral resistance of blood vessels, a decrease in the minute volume of blood and systolic blood pressure. Prophylactic administration of PK-66 leads to normalization of indicators of general hemodynamics in AMI, not inferior in effectiveness to the drug comparison kordaronu.

 

References

ESC Guidelines for the management of acute myocardial. Retrieved from: https: //www.escardio.org/static_file/Escardio/Guidelines/2017%20STEMI%20ehx393_web%20addenda%20-%20FOR%20WEB.pdf.

Chapalamadugu, K. C., Gudla, S., Kukreja, R., & Tipparaju, S. M. (2017). Myocardial Infarction: Disease Mechanisms and Therapeutic Perspectives. Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research, A. Malhotra, S. Soni (Eds.), (pp. 139–160). Hershey, PA: IGI Global. doi: 10.4018/978-1-5225-2092-4.ch008.

Hausenloy, D. J., Garcia-Dorado, D., Bøtker, H. E., Davidson, S. M., Downey, J., Engel, F. B., et al. (2017) Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovascular Research, 113(6), 564–585. doi: 10.1093/cvr/cvx049.

Matthaios, I., Kaladaridou, A., Skaltsiotes, E., Agrios, J., Antoniou, A., Georgiopoulos, G., et al. (2017) Acute Haemodynamic and Echocardiographic Effects of Multiple Configurations of Left Ventricular Pacing Sites in Acute Myocardial Infarction: Experimental Study. Heart Lung Circ. 26(4), 383–394. doi: 10.1016/j.hlc.2016.07.016.

Houser, S. R., Margulies, K. B., Murphy, A. M., Spinale, F. G., Francis, G. S., Prabhu, S. D., et al. (2012). Animal models of heart failure: a scientific statement from the American Heart Association. Circulation research, 111(1), 131–150. doi: 10.1161/RES.0b013e3182582523.

Moyé, L. (2016). Statistical Methods for Cardiovascular Researchers. Circulation Research, 118(3), 439–453. doi.org/10.1161/CIRCRESAHA.115.306305.

Gao, H., Aderhold, A., Mangion, K., Luo, X., Husmeier, D., & Berry, C. (2017). Changes and classification in myocardial contractile function in the left ventricle following acute myocardial infarction. Journal of the Royal Society Interface, 14(132), 20170203. doi: 10.1098/rsif.2017.0203.

Maciel, L., de Oliveira, D. F., Verissimo da Costa, G. C., Bisch, P. M., & Nascimento, J. H.M. (2017) Cardioprotection by the transfer of coronary effluent from ischaemic preconditioned rat hearts: identification of cardioprotective humoral factors. Basic Research in Cardiology, 112(5), 52–67. doi: 10.1007/s00395-017-0641-2.

Elgendy, I. Y., Winchester, D. E., & Pepine, C. J. (2016). Experimental and early investigational drugs for angina pectoris. Expert Opinion on Investigational Drugs, 25(12), 1413–1421. doi: 10.1080/13543784.2016.1254617.

How to Cite

1.
Dzhygalyuk OV, Stepaniuk GI, Lysenko DA. Hemodynamics in experimental acute myocardial ischemia against the background of the use of substance PK-66 in comparison with the cordarone. Current issues in pharmacy and medicine: science and practice [Internet]. 2018Jun.20 [cited 2024Jul.21];(2). Available from: http://pharmed.zsmu.edu.ua/article/view/133510

Issue

Section

Original research