THERMOGRAVIMETRIC INVESTIGATIONS OF VAGINAL SUPPOSITORY WITH THYME OIL
DOI:
https://doi.org/10.14739/2409-2932.2015.1.41385Keywords:
Drug Discovery, Suppositories, Thermogravimetry, Pharmaceutical TechnologyAbstract
One of the main stages in new medicines creation is the development of their making technology. Technological process of suppository making includes ratherlongthermal treatment during preparation and homogenization of suppository base, active substancesaddition. These factors create danger of chemical and physical transformation of active substances and excipients in suppository up to their destruction and change of pharmacological and physical-chemical properties. Use of thermogravimetric analysis in pharmaceutical technology allows to studythepossibility of chemical interaction in dosage forms over the wide temperature range.
The aim of this work is study of thermal treatmenteffects of suppository base with thyme oil over the temperature range of suppository manufacturing.
Methods and results. As an object of thermogravimetric study vaginal suppository with thyme oil 0,2 g, suppository-placebo containing propylenglycol, polyethylene glycol 400, proxanol 268, twin 80 and the active ingredient of «Царствоароматов», Ukraine, production were used. Thermogravimetric analysis was carried out on the derivatograph«Shimadzu DTG-60», Japan, with the platinum and platinum-rhodiumthermopair with samples heating in aluminiumcrucibles from 25 to 200ºС. As standard α-Al2O3was used.Heating rate was 10ºСper min.Mass of the samples was 23,45– 39,63 mg. Obtained data were registered by the derivatograph as curves T, DTA, TGA. The T curve on the derivatogramm shows the temperature change and the TGA curve demonstrates the sample mass change during investigation. The DTA curve reflects differentiation of thermal effects and contains information about endothermic and exothermal maximum and is used for qualitative valuation of derivatogramm.
According to results of thermogravimetric investigation the thyme oil is thermostable substance which is gradually evaporating during heating. So, at the beginning of study the test sample mass was 23,45 mg at 26,14º С, then the thyme oil mass has been decreased on 1,41% at 50,2º С and on 4,14% at 69,48 ºСaccordingly.
In accordance with results of thermogravimetric study of suppository with thyme oil and placebo vaginal dosage form (base) it was revealed that both objects of investigation don’t reach the critical temperature within 100ºС. That fact isindicated by the insignificant mass loss (3,35% and 3,44%accordingly). Derivatography of compositions upper 100ºС wasn’t carried out because such high temperatures aren’t used in technological process of suppository manufacturing. Melting process of suppository base is going at 53,41°С. Addition of thyme oil in suppository base insignificantly decrease melting temperature of composition to 51,25°С, moreover the mass loss of sample is practically absent (0,04%).
Conclusion. Character of the thermal effects of vaginal suppository with thyme oil on the derivatogrammcoincides with the thermal effects of suppository base. This fact indicates the absence of any chemical interactions between active substance and excipients of application dosage form.
References
Zan`ko, C. N. (2006). Vaginal`nyj kandidoz [Vaginal candidiasis] Okhrana materinstva i detstva, 1(7), 64–71. [in Belarus].
Serova, O. F., Tumanova, V. A., Zarochentseva, N. V., & Menshikova, N. S. (2007). Ostryj vul`vovaginal`nyj kandidoz. Sovremennyj vzglyad na problemu [Acute vulvovaginal candidiasis: the present view of the problem, treatment innovation]. Rossijskij vestnik akushera-ginekologa, 1, 33–41. [in Russian].
Tkachenko, K. G. (2011). E`firnomaslichnye rasteniya i e`firnye masla: dostoinstva i perspektivi [Essential oils plants and essential oils: progress and perspectives, modern tendencies of research and application]. Vestnik Udmurtskogo universiteta, 1, 88–100. [in Russian].
Strukova, E. G., Efremova, A. A., Gontova, A. A., & Sokolova, L. V. (2009). Vozdejstvie e`firnykh masel sibsrskogo regiona na uslovno-patogennye mikroorganismy [Effects of essential oils on the Siberian region of opportunistic pathogens]. Khimiya rastitel`nogo syrya, 4, 79–82. [in Russian].
Golovanov, V. A., Abramova, A. S., & Sumskaya, O. P. (2011). Primenenie fitopreparatov dlya pridaniya antimikrobnykh svojstv tekstil`nym materialam [Application phytopreparations to make antimicrobial properties of textile materials]. Vostochno-Evropejskij zhurnal peredovykh texnologij, 6(52), 6–9. [in Ukrainian].
Melnykova, N. V., Puchkan, L. O., & Fukleva, L. A. (2011). Vstanovlennia parametriv farmatsevtychnoi dostupnosti mazi ta ovuliv z efirnoiu oliieiu chebretsiu dlia likuvannia vahinalnykh zakhvoriuvan [Setting pharmaceutical ointments and ovulas availability of essential oil of thyme to treat vaginal diseases]. Aktualni pytannya farmatsevtychnoi i medychnoi nauky ta praktyky, 24(1), 96–97. [in Ukrainian].
Puchkan, L. O., Mishhenko, A. A., & Mel`nikova, N. V. (2014). Razrabotka i issledovanie novykh fitoterapevticheskikh preparatov s maslom chabreca dlya lecheniya vaginal`nykh zabolevanij u zhenshhin [Development and research of new phytotherapeutic drugs with thyme oil for the treatment of vaginal diseases in women]. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya Medicina Farmaciya, 4(175), 250–252. [in Russian].
Cagageishvili, G. V., Golovkin, V. A., & Groshovyj, T. A. (1987). Biofarmacevticheskie, farmakokineticheskie i tekhnologicheskie aspekty sozdaniya myagkikh lekarstvennykh form (rektal`nye preparaty) [Biopharmaceutical, pharmacokinetic and technological aspects of soft medicinal forms (rectal drugs)]. Tbilisi: Mecniereba. [in Georgia].
Golovkin, V. A., Golovkin, V. V., & Tkachenko, Yu. P. (2006). Lekarstvenye sredstva dlya rektal`nogo primeneniya v pediatrii [Medicines for rectal administration in pediatrics]. Zaporozhye: Prosvita. [in Ukrainain].
Korolev, D. V., & Suvorov, K. A. (2003). Opredelenie fiziko-khimicheskikh svojstv komponentov i smesej derivatograficheskim metodom [Determination of physico-chemical properties of the components and mixtures grav method]. Saint Petersburg [in Russian].
Timaniuk, V. A., & Zhivotova, E. N. Biofizika [Biophysics]. (2003). Kharkov: Zolotie stranici. [in Ukrainain].
Trunova, T. V., Krutskikh, T. V., & Kukhtenko, O. S. (2010). Termohravimetrychni doslidzhennia supozytoriiv z N, N~dybenzylamidom malonovoi kysloty (dybamkom) [Thermogravimetric study suppositories with N, N~dibenzylamid malonic acid (dibamk)]. Farmatsevtychnii chasopys, 4, 35–38. [in Ukrainain].
Strilets, O. P. (2010). Termohrafichne doslidzhennya novoho kombinovanoho preparatu iz hipotenzyvnoyu diyeyu [Thermographic study of the new combined drug antihypertensive effect]. Ukrainskyi zhurnal klinichnoi i laboratornoi medytsyny, 5(4), 29–31. [in Ukrainain].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
