Cardiohemodynamics in patients with multiple myeloma depending on renal function
Keywords:cardiohemodynamics, multiple myeloma, renal function
Purpose – to evaluate cardiohemodynamics in patients with multiple myeloma depending on renal function.
Materials and methods. Thirty-five subjects with multiple myeloma were enrolled in the study. They were divided into groups depending on the glomerular filtration rate (GFR). The first group involved 10 patients with GFR 30–59 ml/min/1.73 m2, the second one – 11 patients with GFR 60–89 ml/min/1.73 m2, the third one – 14 patients with normal renal function. All patients and control subjects underwent echocardiography.
Results. In patients with GFR 30–59 ml/min/1.73 m2 ejection fraction was significantly lower in comparing with healthy persons (54.69 [51.15; 57.70] % versus 59.82 [57.81; 62.29] %; P = 0.018) mainly due to decreased end systolic volume (ESV) (54.91 [43.21; 59.27] ml versus 34.22 [31.72; 41.24] ml; P = 0.035). In this group ESV was significantly lower in comparing with patients with normal renal function.
In patients with GFR 30–59 ml/min/1.73 m2 E (0.90 [0.76; 1.02] m/s versus 1,01 [1.02; 1.24]; P = 0.014), A (0.87 [0.76; 1.05] m/s versus 0.73 [0.56; 0.85] m/s; P = 0.023). E/A (9.30 [7.09; 11.15] versus 1.16 [1.06; 1.25]; P = 0.011) were significantly lower in in comparing with control. Global circular systolic strain (-17.62 [-21.09; -15.19] versus -25.92 [-26.09; -19.15]; P = 0.012) and global circular systolic strain rate (-1.26 [-1.30; -1.21] versus -1.32 [-1.42; -1.25]; P = 0.023) was significantly lower in group of patients with GFR 30–59 ml/min/1.73 m2 in comparing with healthy persons.
Conclusions. Our data suggest that the extent of renal function is directly associated with left ventricle diastolic and regional systolic parameters. Among patients with multiple myeloma and renal insufficiency systolic, diastolic and regional systolic contractility were significantly worse in comparing with patients with normal renal function and healthy persons.
Cowan, A., Allen, C., Barac, A., Basaleem, H., Bensenor, I., & Curado, M. et al. (2018). Global Burden of Multiple Myeloma: A Systematic Analysis for the Global Burden of Disease Study 2016. JAMA Oncology, 4(9), 1221-1227. doi: 10.1001/jamaoncol.2018.2128
Altekruse, S. F., Kosary, C. L., Krapcho, M., Neyman, N., Aminou, R., & Waldron, W. et al. (2010). SEER Cancer Statistics Review, 1975-2007. National Cancer Institute, Bethesda. Retrieved from https://seer.cancer.gov/archive/csr/1975_2007/#citation.
Turesson, I., Velez, R., Kristinsson, S., & Landgren, O. (2010). Patterns of multiple myeloma during the past 5 decades: stable incidence rates for all age groups in the population but rapidly changing age distribution in the clinic. Mayo Clinic Proceedings, 85(3), 225-230. doi: 10.4065/mcp.2009.0426
Kuznietsova, L. P., & Panasenko, M. O. (2019). Komorbidna patolohiia u khvorykh na mnozhynnu miielomu [Comorbidities in patients with multiple myeloma]. Current issues in pharmacy and medicine: science and practice, 12 (2), 222-227. doi: 10.14739/2409-2932.2019.2.171245 [in Ukrainian].
Samura B. B. (2015). Prognosticheskaja rol galektina-3 u pacientov so mnozhestvennoj mielomoj v remissii [Predictive value of circulating galectin-3 in patients with multiple myeloma in remission]. Zaporozhye medical journal, 4(91), 11-16. doi: http://dx.doi.org/10.14739/2310-1210.2015.4.50298 [in Russian].
Korbet, S., & Schwartz, M. (2006). Multiple Myeloma. Journal Of The American Society Of Nephrology, 17(9), 2533-2545. doi: 10.1681/asn.2006020139
Eleutherakis-Papaiakovou, V., Bamias, A., Gika, D., Simeonidis, A., Pouli, A., & Anagnostopoulos, A. et al. (2007). Renal failure in multiple myeloma: Incidence, correlations, and prognostic significance. Leukemia & Lymphoma, 48(2), 337-341. doi: 10.1080/10428190601126602
Dimopoulos, M., Kastritis, E., Rosinol, L., Bladé, J., & Ludwig, H. (2008). Pathogenesis and treatment of renal failure in multiple myeloma. Leukemia, 22(8), 1485-1493. doi: 10.1038/leu.2008.131
Dimopoulos, M., Sonneveld, P., Leung, N., Merlini, G., Ludwig, H., & Kastritis, E. et al. (2016). International Myeloma Working Group Recommendations for the Diagnosis and Management of Myeloma-Related Renal Impairment. Journal Of Clinical Oncology, 34(13), 1544-1557. doi: 10.1200/jco.2015.65.0044
(2015). Unifikovanyi klinichnyi protokol pervynnoi, vtorynnoi (spetsializovanoi), tretynnoi (vysokospetsializovanoi) medychnoi dopomohy. Mnozhynna miieloma: nakaz MOZ Ukrainy vid 02.11.2015 roku №710. [Unified Clinical Protocols of primary, secondary (specialized) and tertiary (highly specialized) medical care. Multiple myeloma]. Retrieved from https://zakon.rada.gov.ua/rada/card/v0710282-15. [in Ukrainian].
Gardin, J., Adams, D., Douglas, P., Feigenbaum, H., Forst, D., & Fraser, A. et al. (2002). Recommendations for a standardized report for adult transthoracic echocardiography: A report from the American Society of Echocardiography's Nomenclature and Standards Committee and Task Force for a Standardized Echocardiography Report. Journal Of The American Society Of Echocardiography, 15(3), 275-290. doi: 10.1067/mje.2002.121536
Otto K. M. (2019). Prakticheskaja jehokardiografija: Rukovodstvo po jehokardiograficheskoj diagnostike [Practical echocardiography: Guidelines for the Echocardiographic diagnostics]. Moscow: MEDpress-inform. [in Russian].
Lapach, S. N., Chubenko, A. V., & Babych, P. N. (2002). Statystyka v nauke y byznese [Statistics in science and business]. Kyiv: Morion. [in Russian].
How to Cite
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)