Cardiohemodynamics in patients with multiple myeloma depending on renal function
DOI:
https://doi.org/10.14739/2409-2932.2019.3.184240Keywords:
cardiohemodynamics, multiple myeloma, renal functionAbstract
Purpose – to evaluate cardiohemodynamics in patients with multiple myeloma depending on renal function.
Materials and methods. Thirty-five subjects with multiple myeloma were enrolled in the study. They were divided into groups depending on the glomerular filtration rate (GFR). The first group involved 10 patients with GFR 30–59 ml/min/1.73 m2, the second one – 11 patients with GFR 60–89 ml/min/1.73 m2, the third one – 14 patients with normal renal function. All patients and control subjects underwent echocardiography.
Results. In patients with GFR 30–59 ml/min/1.73 m2 ejection fraction was significantly lower in comparing with healthy persons (54.69 [51.15; 57.70] % versus 59.82 [57.81; 62.29] %; P = 0.018) mainly due to decreased end systolic volume (ESV) (54.91 [43.21; 59.27] ml versus 34.22 [31.72; 41.24] ml; P = 0.035). In this group ESV was significantly lower in comparing with patients with normal renal function.
In patients with GFR 30–59 ml/min/1.73 m2 E (0.90 [0.76; 1.02] m/s versus 1,01 [1.02; 1.24]; P = 0.014), A (0.87 [0.76; 1.05] m/s versus 0.73 [0.56; 0.85] m/s; P = 0.023). E/A (9.30 [7.09; 11.15] versus 1.16 [1.06; 1.25]; P = 0.011) were significantly lower in in comparing with control. Global circular systolic strain (-17.62 [-21.09; -15.19] versus -25.92 [-26.09; -19.15]; P = 0.012) and global circular systolic strain rate (-1.26 [-1.30; -1.21] versus -1.32 [-1.42; -1.25]; P = 0.023) was significantly lower in group of patients with GFR 30–59 ml/min/1.73 m2 in comparing with healthy persons.
Conclusions. Our data suggest that the extent of renal function is directly associated with left ventricle diastolic and regional systolic parameters. Among patients with multiple myeloma and renal insufficiency systolic, diastolic and regional systolic contractility were significantly worse in comparing with patients with normal renal function and healthy persons.
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