The study of structural-mechanical properties of diltiazem suppositories

Authors

  • L. К. Kuchina
  • S. А. Gladyshevа
  • I. A. Puchalskaya

DOI:

https://doi.org/10.14739/2409-2932.2015.2.45197

Keywords:

Diltiazem, Suppositories, Transition Temperature, Rheology, «Mechanical Phenomena»

Abstract

Using alternative ways of diltiazem absorption, in particular, rectal, will allow to improve its bioavailability and efficiency.

Aim. To study the structural-mechanical properties of diltiazem suppositories.

Methods and results. For the investigation of the influence of temperature of suppository manufacturing technological process on the structural-mechanical properties of diltiazem rectal dosage rheological properties of the suppository mass with diltiazem on the factory fat base with 2% of distilled monoglycerides has been studied.

Conclusion. It has been determined that temperature 50-55ºС for the technological operations of homogenization and pouring suppositories is optimal and necessary fluidity of the suppository mass with even distribution of active substances and excipients is provided.

References

  1. Lysianskaia А.P., Fаdi Аl Zеdan, Аlmokhамаd Zhuмаа Аbdullakh, Gladyshеv V.V., Zavadskaia I.V. О tsеlеsооbraznosti ispolzоvаniia transmukoznykh мiagkikh leкаrstvеnnykh fоrm v fаrмакоtеrаpеvtichеsкоi kоrrеktsii аrtеriаlnoi gipertenzii [About expedience of the use of transmucoses of soft medicinal forms in the pharmacotherapeutic correction of hyperpiesis]. Маteriali VІІ Natsіоnаlnogо zizdu farmatsеvтіv Ukraini «Farmatsіia Ukraini. Pogliad u maibutnie» [Materials of VІІ of National convention of farmaceutical of Ukraine «Farmacia of Ukraine. A look is in the future»]. Kharkiv, 2010, Т. 1, р. 509.
  2. Коsаrev V.V., Babanov S.А. (2010). Аntagonisti kaltsiia: kliniko-farmakologichеskiе podkhоsi pri аrterialnoi gipertenzii. Russkii meditsinskii gurnal, (10), 652-657.
  3. Miasoedova S.E. (2014). Diltiazem: mesto v sovremennoi terapii serdechno-sosudistykh zabolevanii. Atmosfera. Novosti kardiologii, (3), 11 – 16.
  4. Kuchina L.K.., Gladyshеv V.V., Kechin I.L., Biriuk I.A. (2015). Vuvchennia vplyvy kontsentratsii poverkhnevo-aktuvnych rechovin na vyvilnennia diltiazemu z rektalnykh supozitoriev. Farmatsevtychnii gurnal, (1), 15 – 19.
  5. Kuchina L.K.., Gladyshеva S.A. Biofarmatsevticheskie issledovaniia miagkoi rektalnoi lekarstvennoi formy diltiazema [Biopharmaceutical researches of soft rectal medicinal form of diltiazem]. Маteriali IY mignarodnoi naukovo-praktichnoi konferentsii “Suchasni dosiagnennia farmatsevtichnoi tekhnologii i biotekhnologii” [Materials of IY of international науково-практичної conference are «Modern achievements of pharmaceutical technology and biotechnology»]. Kharkiv, 2014, р. 184.
  6. Lysianskaia А.P., Gladyshеv V.V., Burlaka B.S. Izuchenie strukturno-mekhanichrskikh kharakteristik suppozitornykh mass s enalaprila maleatom [Study of structurally-mechanical descriptions of the suppositories masses with enalaprila maleat]. Маteriali II naukovo-praktichnoi konferentsii s mizhnarodnoiu uchastiu “Suchasni dosiagnennia farmatsevtichnoi tekhnologii”[ Materials of II of науково-практичної conference with international participation «Modern achievements of pharmaceutical technology»]. Kharkiv, 2011, рp. 112-113.
  7. Fаdi Аl Zеdan, Gladyshеv V.V., Burlaka B.S. , Nagornii V.V. (2013). Izuchenie strukturno-mekhanicheskikh svoistv suppositoriev s amlodipinom. Zaporozhskii meditsninskii gurnal, (1), 63 – 66.
  8. Tikhonov O.I., Krivoviaz O.V., Zubchenko T.M. (2010). Vyvchennia strukturno-mekhanicheskikh vlastivostei supozitoriev z vmistom fenolnogo gidrofobnogo preparatu propolisu ta lipofilnogo ekstraktu pylku kvitkovogo. Visnyk farmatsii, (4), 3 – 6.
  9. Nagornaia N.A., Burlaka B.S. , Gladyshеva S.A. (2014). Izuchenie strukturno-mekhanicheskikh svoistv suppositoriev s vinpotsetinom. Aktualni pytannia farmatsevtichnji i medichnoi nauki ta praktiki, (1), 39 – 42.
  10. Tentsova A.I., Gretskii V.M. (1980). Sovremennye aspekti issledovaniia i proizvodstva mazei [Modern aspects of research and production of ointments]. Moskva: Meditsina.

Downloads

How to Cite

1.
Kuchina LК, Gladyshevа SА, Puchalskaya IA. The study of structural-mechanical properties of diltiazem suppositories. Current issues in pharmacy and medicine: science and practice [Internet]. 2015Jul.14 [cited 2026Jul.2];(2). Available from: https://pharmed.zsmu.edu.ua/article/view/45197

Issue

No. 2 (2015)

Section

Pharmaceutical manufacturing

License

Authors who publish with this journal retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
 Лицензия Creative Commons