Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles

Authors

  • O. A. Suhak
  • O. I. Panasenko
  • Ye. G. Knysh

DOI:

https://doi.org/10.14739/2409-2932.2015.2.45130

Keywords:

1, 2, 4-triazoles, IR-spectroscopy, HPLC-mass Spectrometry, Synthesis

Abstract

Aim. Selection, synthesis and biological properties of new compound play major role in creating original medicines.

Methods and results. Therefore, to find new bioactive compounds 3-(alkylthio)-4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles, where R - methyl, ethyl, phenyl, have been synthesized, by alkylation reaction of 4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-thiols with 1-bromobutane, or 1-bromopentane, or 1-bromohexane, 1-bromoheptane, 1-bromooctane, 1-bromononane, 1-bromodekane in the n-butanol medium and their physical-chemical properties have been studied using modern physical-chemical methods of analysis, elemental analysis, IR spectroscopy, and their individuality using HPLC-MS.

Conclusion. This suggests the possibility of further studying the biological effect of the synthesized compounds.

References

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1.
Suhak OA, Panasenko OI, Knysh YG. Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles. Current issues in pharmacy and medicine: science and practice [Internet]. 2015Jul.14 [cited 2026Jul.2];(2). Available from: https://pharmed.zsmu.edu.ua/article/view/45130

Issue

No. 2 (2015)

Section

Synthesis of the biologically active compounds

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