The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives
DOI:
https://doi.org/10.14739/2409-2932.2014.2.26165Keywords:
Pharmacological Actions, Drug Screening, Animal Experimental, Toxic Hepatitis, 1, 2, 4-triazoleAbstract
Aim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats.
Methods and results. Compounds have been entered in a 1/10 dose of LD50, which have been determined before performing experiments. The article presents hepatoprotective activity of new synthesized compounds in simulated acute liver injury. We present a comparison with reference drugs in the experiment.
Сonclusion. Screening has shown that these class of compounds is promising for further research.
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