Chromato-mass-spectroscopic research of chemical composition of Elaeagnus angustifolia L.

Authors

  • O. I. Panasenko Zaporizhzhia State Medical University, Ukraine, Ukraine https://orcid.org/0000-0002-6102-3455
  • V. I. Mozul Zaporizhzhia State Medical University, Ukraine, Ukraine
  • O. M. Denysenko Zaporizhzhia State Medical University, Ukraine, Ukraine
  • I. I. Aksonova Zaporizhzhia State Medical University, Ukraine, Ukraine https://orcid.org/0000-0002-3534-700X
  • T. V. Oberemko LLC “PMD-UKRAINE”, Kyiv, Ukraine

DOI:

https://doi.org/10.14739/2409-2932.2021.2.233708

Keywords:

Elaeagnus angustifolia, GS-MS, antimicrobial action, antidiabetic action, cytotoxic action, anti-inflammatory action, biological activity

Abstract

The aim of the work was chromato-mass-spectroscopic research of chemical composition of Elaeagnus angustifolia L. fruits and leaves and identifying further prospects for the use of this plant in medicine.

Materials and methods. Raw materials of Elaeagnus angustifolia L. were selected as objects of study. The tincture was obtained by maceration and the raw material was extracted with methyl alcohol at room temperature for 10 days according to the method of making tinctures. The study of the chemical composition of Elaeagnus angustifolia L. was carried out using gas chromatograph Agilent 7890B GC System (Agilent, Santa Clara, CA, USA) with mass spectrometric detector Agilent 5977 BGC/MSD (Agilent, Santa Clara, CA, USA) and chromatographic column DB-5ms (30 m × 250 mkm × 0,25 mkm).

Results. 23 compounds (1 in the isomeric state) in fruits and 20 compounds (2 in the isomeric state) in the leaf of Elaeagnus angustifolia L. were identified. The main components of fruits were sitosterol (phytosterols) – 12.53 %, propyl acetate (esters of carboxylic acids) – 12.60 %, chamazulene (terpenes) – 11.97 % and palmitic acid (fatty acids) – 8.28 %. The main component of leaves were sitosterol (phytosterols) – 17.57 %, 1-(2-hydroxy-5-methylphenyl)-ethanone (ketone) – 8.35 %, phytol (terpenes) – 6.10 %.

It is known from the literature that chamazulene has antioxidant, antinociceptive, cytotoxic activity. Sitosterol has anti-inflammatory and antidiabetic activity. Hexadecanoic (palmitic) acid has antimicrobial, antidiabetic and antioxidant properties. Phytol is characterized by a wide range of biological action – antimicrobial, antinociceptive, anti-inflammatory, antioxidant and cytotoxic.

Conclusions. Based on the above, the olive can be considered as a source of antimicrobial, antinociceptive, anti-inflammatory, antioxidant, antidiabetic and cytotoxic drugs.

Author Biographies

O. I. Panasenko, Zaporizhzhia State Medical University, Ukraine

PhD, DSc, Professor, Head of the Department of Natural Sciences for Foreign Students and Toxicological Chemistry

V. I. Mozul, Zaporizhzhia State Medical University, Ukraine

PhD, Associate Professor of the Department of Pharmacognosy, Pharmacology and Botany

O. M. Denysenko, Zaporizhzhia State Medical University, Ukraine

PhD, Associate Professor of the Department of Pharmacognosy, Pharmacology and Botany

I. I. Aksonova, Zaporizhzhia State Medical University, Ukraine

PhD, Teaching Assistant of the Department of Pharmacognosy, Pharmacology and Botany

T. V. Oberemko, LLC “PMD-UKRAINE”, Kyiv

Director

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Published

2021-06-01

How to Cite

1.
Panasenko OI, Mozul VI, Denysenko OM, Aksonova II, Oberemko TV. Chromato-mass-spectroscopic research of chemical composition of Elaeagnus angustifolia L. Current issues in pharmacy and medicine: science and practice [Internet]. 2021Jun.1 [cited 2026Jul.1];14(2):179-84. Available from: https://pharmed.zsmu.edu.ua/article/view/233708

Issue

Vol. 14 No. 2 (2021)

Section

Original research

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