State of care in patients with endometrial cancer in Zaporizhzhia region since 2008 to 2015 year

Authors

  • O. P. Kolesnik Zaporizhzhia State Medical University,
  • A. V. Kadzhoian Zaporizhzhia State Medical University,
  • A.O. Kabakov Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2409-2932.2017.1.93449

Keywords:

Endometrial Сancer, Morbidity, Survival

Abstract

Endometrial Cancer (EC) is a relevant problem both in Ukraine and in the world.

Aim. Our goal was to analyze morbidity and survival rate of the EC patients in Zaporizhzhia region from 2008 to 2015 and to study the state of giving help to the mentioned category of patients.

Materials and methods. During the study it was revealed that from 2008 to 2015 in Zaporozhye 2719 patients with EC where registered. Total survival rate of this category of patients made 68.8 % in 5 years period.

During the research it was found that we can relate the stage of the disease, morphological type of the tumor and age of the patient to the factors which impact the total survival rate of the patients with EC. Thus, the best survival rate is determined among women with the first stage of neoplastic process, it made 81.0 %, also the highest indexes where determined in age group from 45 to 65, which made 76.8 %. And total survival rate of adenocarcinoma EC made 72.6 % (p < 0,05).

Results. During the ranking of the conducted treatment effectiveness the next sequence can be mentioned: 1 place - surgery without radiotherapy and chemotherapy, the overall 5-year survival rate for patients who received this type of treatment was 86.9 % (p <0.05); second place - combined treatment (surgery + radiotherapy), the overall 5-year survival rate for these women was 85.2 % (p < 0.05); third place - complex treatment (surgery + radiotherapy + chemotherapy), the overall 5-year survival rate for patients in this case amounted to 65.0 % (p < 0.05); fourth place - patients who received integrated treatment (radiotherapy + chemotherapy), the overall 5-year survival rate – 57.3 % (p < 0.05); fifth place - surgery + chemotherapy, the overall 5-year survival rate – 55.0 % (p < 0.05). The worst outcome of treatment was seen in women with ER who received radiotherapy in mono and palliative chemotherapy: overall 5-year survival rate was 47.4% (p < 0.05) and 42.7 % (p < 0.05), respectively. It is important to understand that one of the reasons for such a high efficiency of surgical mono treatment is its use in patients with initial stages of OM.

Conclusion. The given research allowed us to set goals, completing which is necessary for improving aid for patients with EC in Zaporizhzhia. Thus, we have to establish the clear surgical staging of EC, the detailed staging and treatment data entry into cancer-register. We need to improve the quality and control of regular medical examination by gynecologist, which will allow to diagnose EC on the early stages. Treatment of EC patients must be performed in specialized medical centers, which will improve both immediate and further results of this pathology treatment.

References

(2015) Global cancer rates could increase by 50% to 15 million by 2020. Cancer by the Numbers, 5.

Torre, L. A., Bray, F., Siegel, R. L., Ferlay, J., Lortet-Tieulent, J., & Jemal, A. (2015) Global cancer statistics, 2012. CA Cancer J Clin, 65, 87. doi: 10.3322/caac.21262.

Alteri, R., Bertaut, T., Brooks, D., Chambers, W., Chang, E. Chen, M. S. et al. (2012) Cancer Facts and Figures is an annual publication of the American Cancer Society. Atlanta, Georgia. (Table 1), (P. 4).

Fedorenko, Z. P., Mykhailovych, Yu. I., Gulak, L. O., et al (2012) Rak v Ukraini, 2012–2013 [Cancer in Ukraine, 2012–2013]. Biuleten Natsionalnoho kantser-reiestru Ukrainy, 15, 48. [in Ukrainian].

Nechushkina, V. M., Morkhov, K. Y., & Kuznecov, V. V. (2011) Klassifikaciya stadij raka tela matki (FIGO, 2009 g.): Preimushchestva i nedostatki [Classification of herds uterine cancer embolism (FIGO, 2009.): Advantages and Disadvantages]. Vestnik RONC im. N.N. Blohina RAMN, 4, 56. [in Russian].

Alteri, R., Bertaut, T., Brooks, D., Chambers, W., Chang, E., Chen, M. S. et al (2016) Cancer Facts and Figures is an annual publication of the American Cancer Society. Atlanta, Georgia. (Table 8), (P. 23).

How to Cite

1.
Kolesnik OP, Kadzhoian AV, Kabakov A. State of care in patients with endometrial cancer in Zaporizhzhia region since 2008 to 2015 year. Current issues in pharmacy and medicine: science and practice [Internet]. 2017Feb.20 [cited 2024Feb.26];(1). Available from: http://pharmed.zsmu.edu.ua/article/view/93449

Issue

Section

Original research