Sodium 2-(4-amino-(5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate, synthesis, study of biochemical indicators of blood serum cows in its use

Authors

  • D. M. Danilchenko Zaporizhzhia State Medical University,
  • T. V. Zvenigorodska Poltava State Agricultural University,
  • V. V. Parchenko Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2409-2932.2017.1.93446

Keywords:

1, 2, 4-triazole derivatives, synthesis, biochemical indicators

Abstract

Introduction. Heterocyclic system of 1,2,4-triazole is interesting and has a popularity among scientists around the world every year. Most attention today is attracted to the compounds formed by a combination of 1,2,4-triazole and various structural residues of an aliphatic, aromatic, heterocyclic nature. Recent publications on the study of physical, chemical and biological properties of 1,2,4-triazole substituted prove the obvious relevance of the search for potential pharmacologically active molecules is among the water-soluble derivatives of 1,2,4-triazole. It should be noted that 1,2,4-triazole derivatives are successfully used in veterinary practice as original domestic drugs.

The aim of our work was to synthesize the sodium 2-(4-amino-(5-(furan-2-yl)-1,2,4-triazole-3-ylthio) acetate for which we decided to provide a comparative screening studies on determination of some biochemical parameters of cows blood serum and determine the possibility of its further implementation.

Materials and methods of research. As the starting compound for the synthesis it was used a 2-(4-amino-(5-(furan-2-yl)-1,2,4-triazol-3-ylthio) acetic acid. The obtained compound is an individual white crystalline substance, which is soluble in water but insoluble in organic solvents.

Results and discussion. At the first day of administration of sodium 2-(4-amino-(5-(furan-2-yl)-1,2,4-triazole-3-ylthio) acetate in experimental animals it was recorded significant increase in total protein content of the serum, γ-globulin, reduction of enzyme activity of lactate dehydrogenase and alkaline phosphatase.

On the third day it was marked increase in total protein, γ-globulin, and decrease of activity of LDH and LF. On the seventh day in the experimental animals was recorded increase of total protein and γ-globulins. Decreased activity of LDH and exercise therapy.

Conclusions. First we synthesized sodium 2-(4-amino-(5-(furan-2-yl)-1,2,4-triazol-3-ylthio) acetate whose structure is confirmed by complex physical and chemical analysis methods. According to the results of the experiment revealed that intramuscular administration of 1 % aqueous solution of sodium 2-(4-amino-(5-(furan-2-yl)-1,2,4-triazole-3-ylthio) acetate cows enhances total protein, γ-globulin, reduce LDH activity in cow blood serum and LF. Thus, this salt is a perspective in future implementation and can be recommended as a compound which has antioxidant, hepatoprotective, immunomodulating activity by increasing the basic biochemical indicators.

References

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How to Cite

1.
Danilchenko DM, Zvenigorodska TV, Parchenko VV. Sodium 2-(4-amino-(5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate, synthesis, study of biochemical indicators of blood serum cows in its use. Current issues in pharmacy and medicine: science and practice [Internet]. 2017Feb.20 [cited 2024Jun.16];(1). Available from: http://pharmed.zsmu.edu.ua/article/view/93446

Issue

Section

Experimental and clinical pharmacology