Synthesis, physical-chemical properties of 2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides

Authors

  • O. A. Suhak Zaporizhzhia State Medical University,
  • O. I. Panasenko Zaporizhzhia State Medical University,
  • Ye. G. Knysh Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2409-2932.2017.1.93432

Keywords:

1, 2, 4-triazoles, hydrazides, ylidene hydrazides, synthesis

Abstract

Aim. Analysis of the scientific literature over the past decade has shown that large synthetic possibilities towards creating new and effective drug substances have heterocyclic compounds, in particular the derivatives of 1,2,4-triazole. 1,2,4-Triazole is a structural fragment of many synthetic drugs. The special interest cause ylidene hydrazides of 2-(5-R-1,2,4-triazole-3-ylthio)acetic acids as potential biologically active compounds, among which highly effective medicines can be found. With the aim of finding new biologically active compounds the derivatives of 2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)aceticohydrazides have been synthesized, their physical-chemical properties have been studied with the use of modern methods, namely elemental analysis, IR,1H-NMR spectroscopy, and their individuality by HPLC-MS.

Materials and methods. N'-R1-еden-2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)aceticohydrazides were received by adding aromatic (2-BrC6H4, 2,3-(OCH3)2C6H3, 3,5-(OCH3)2C6H3, 4-N(CH3)2C6H4, 3,4-F2C6H3, 2-NO2C6H4,4-NO2C6H4, 4-OHC6H4, 2-OHC6H4, 4-FC6H4, 2-CI-6-FC6H3) or heterocyclic (2-SC4H3, 5-NO2-2-C4H2O) aldehyde to an equivalent amount of the appropriate 2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)aceticohydrazide in the acetic acid medium. The study of physical-chemical properties of obtained compounds was carried out according to the methods outlined in SPU. Chromato-mass-spectral studies were performed on hazarding chromatograph Agilent 1260 Infinity HPLC equipped with mass spectrometer Agilent 6120 with ionization in electro-spray (ESI).

Conclusion. This suggests the possibility for further study of biological action of the synthesized compounds. As a result of studies the N'-R1-eden-2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)aceticohydrazides have been synthesized and their physical-chemical properties have been studied.

References

Kazicyna, L. A., & Kupletskaya, N. B. (1971) Primenenie UF-,IK-, i YaMR-spektroskopii v organicheskoj khimii [Applicationof UV, IR, and NMR spectroscopyinorganicchemistry]. Moscow. [in Russian].

Pruhlo, Ye. S., Odyntsova, V. M., & Safonov, А. А. (2013) Zharoznyzhuvalna diia novykh hidrazydiv 2-(5-(adamantan-1-il)-4-r-1,2,4-triazol-3-iltio)atsetativ [Antipyretic effect of new hydrazide 2-(5-(adamantane-1-yl)-4-r-1,2,4-triazole-3-ylthio) acetate]. Farmatsevtychnyi chasopys, 3, 45–49. [in Ukrainian].

Safonov, A. A., Panasenko, T. V., Knysh, Ye. H., & Polishchuk, N. M. (2015) Protymikrobna ta protyhrybkova diia 4-((R-iden)amino)-5-(tiofen-2-ilmetyl)-4H-1,2,4-tryazol-3-tioliv [Antimicrobial and antifungal properties of 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4N-1,2,4-triazole-3-thiol]. Farmatsevtychnyi zhurnal, 2, 96–99. [in Ukrainian].

Salionov, V. A., Panasenko, A. I., & Knysh, E. G. (2012) Syntez, fizyko-khimichni vlastyvosti 2-(4-R-5-(tiofen-2-il)-4N-1,2,4-triazol-3-iltio)atsetatnykh kyslot ta yikh solei [Synthesis and physicochemical properties of 2-(4-R-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-ylthio)acetic acids and their salts]. Ukrainskyi biofarmatsevtychnyi zhurnal, 5–6, 114–117. [in Ukrainian].

Suhak, O. A., Panasenko, O. I., & Knysh, Ye. H. (2015) Syntez ta fizyko-khimichni vlastyvosti 3-(alkiltio)-4-R-5-(tiofen-2-ilmetyl)-4N-1,2,4-triazoliv [Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles]. Current issues in pharmacy and medicine: science and practice, 2, 21–24 [in Ukrainian]. doi: http://dx.doi.org/10.14739/2409-2932.2015.2.45130.

Downloads

How to Cite

1.
Suhak OA, Panasenko OI, Knysh YG. Synthesis, physical-chemical properties of 2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides. CIPM [Internet]. 2017Feb.20 [cited 2023Dec.9];(1). Available from: http://pharmed.zsmu.edu.ua/article/view/93432

Issue

No. 1 (2017)

Section

Synthesis of the biologically active compounds

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.     Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)