The use of compaction in the manufacture of tablets

Authors

  • O. V. Tryhubchak Ternopil State Medical University named after I. Horbachevsky,
  • Т. А. Groshovyj Ternopil State Medical University named after I. Horbachevsky,
  • O. О. Yuryeva Central R&D Laboratory JSC «Farmak»,

DOI:

https://doi.org/10.14739/2409-2932.2016.2.71120

Keywords:

Powders, Mechanical Processes, Tablets

Abstract

In the production of tablets direct compression method, wet and dry granulationare used. Dry granulation can be used if materials have sufficient cohesive properties to form granules. Scientific publications of recent years clearly demonstrate the prospects of roller compaction using in pharmaceutical industry.

Aim. The aim of work is to generalize available data regarding to the use of compaction in the pharmaceutical industry.

Materials and methods. We have studied and analyzed the available scientific sources in order to generalize the available literature on the use of compacting in the production of the tablets. During this study we used methods of observation and systematization analysis.

Results. Materials for compaction characteristics of the process, its benefits and conditions of application have been collected and systematized, parameters of process have been selected, theories of compaction have been generalized, the characteristics and examples of compaction equipment have been adduced, and the key characteristics of the material used in the pharmaceutical industry have been demonstrated.

Compacting is dry granulation technology in which powder containing active ingredients and excipients are compacted between two opposing spinning rollers by applying mechanical pressure. Compared with the original powder, granules after compression are characterized by much better fluidity and higher density by reducing the volume. The roller consolidation process substantially affects the particle size distribution, flowability, homogeneity, pressing, compaction substances and excipients, therefore, can affect dissolution, time of disintegration, resistance to crushing, abrasion of tablets. The main parameters of compacting are seal and method of its application, conditions and speed of the process.

Conclusions. It has been established that the use of compacting decreases or increases particles size to form granules, which leads to improved performance of fluidity powder, granulation avoid moisture induced degradation, improve product stability, prevent segregation, reduction of bulk volume.This indicates the promising future for the compaction technology in the production of medicines that meet pharmaceutical requirements.

References

Albin, Friedrich (2016). Dry Agglomeration Technology. Using BEPEX Roller Compaction Technology. New Jersey: Hosokawa MicronPowder Systems.

Gowtham Kumar Dokala, & Ch. Pallavi. (2013). Direct Compression – An Overview. International Journal of Research in Pharmaceutical and Biomedical Sciences, 4(1), 155–158.

Ayasha Rana, Sukhbir Lal Khokra, Abhishek Chandel, Gauri Prasad Nanda, & Ram Kumar Sahu. (2011). Overview on roll compactio/Dry graulatio process. Pharmacologyonline, 3, 286–298.

Gurpreet Kau, Manoj Gera, Pallavi Bassi, & Ashok K Tiwary. (2011). Roll Compaction/Dry Granulation (Rcdg): Technologies and Their Applications In Drug Delivery and Development. International Journal of Drug Delivery, 3, 397–414.

Pimple Srikant, Joshi Akash, Digge Mahesh, & Swami Astik. (2015). Roller Compaction Design and Critical Parameters in Drug Formulation and Development: Review. International Journal of PharmTech Research, 7(1), 90–98.

(2015). Roller compactors for the pharmaceutical industry. BT 120 Pharma, WP 120 Pharma, WP 150 Pharma, WP 200 Pharma, Remscheid: Alexanderwerk GmbH.

Dhumal, Sonam, Kulkarni, P. A., Kashikar, V. S., Baweja, Jitendra, Thottasseri, Manoj. (2013). A Review: Roller Compaction for Tablet Dosage Form Development. Research and Reviews: Journal of Pharmacy and Pharmaceutical Sciences, 2(4), 68–73.

Shuo-Huan, Hsu, Gintaras, V. Reklaitis, Venkat, Venkatasubramanian. (2010). Modeling and Control of Roller Compaction for Pharmaceutical Manufacturing. Part I: Process Dynamics and Control Framework. Journal of Pharmaceutical Innovation, 5(1), 14–23. doi: 10.1007/s12247-010-9076-0.

Zinchuk, A. V., Hancock, B. C., & Mullarney, M. (2004). Simulation of roller compaction using a laboratory scale compaction simulator. International Journal of Pharmaceutics, 269(2), 403–415.

Robles, E. E., Ved, P. M., Vora, N., Kim, T-Y., Cartwright, D., Williamson, J. A., Kanikkannan, N., & Skultety, P. (2014). Effect of roller compaction pressure on the blend and tablet properties of a formulation containing a poorly soluble drug. Xcelience.

Gereg, G. W., & Cappola, M. L. (2002). Roller Compaction Feasibilityfor New Drug Candidates. LaboratorytoProductionScale. Pharmaceutical Technology. TABLETING & GRANULATION, 14–23.

Mogilyuk, V. (2015). Rolikovye kompaktery v razrabotke i proizvodstve tverdyh lekarstvennykh form [Roller сompaсtors in the design and manufacture of solid dosage forms]. Farmacevticheskaya otrasl', 3(50), 88–94. [in Ukrainian].

Marcin, Balicki. (2003). Numerical methods for predicting roll press powder compaction parameters. France: Ecole Des Mines D'Albi-Carmaux. [in France].

Borisenko, A. (2008). Kompaktirovanie poroshkov – al'ternativa granulirovaniyu v psevdoozhizhennom sloe [Compacting powders – an alternative to granulation in a fluidized bed]. Promyshlennoe obozrenie, 5(10), 58. [in Ukrainian].

Saikh Mahammed Athar Alli. (2014). “Gerteis®” An Advanced Technology of Roller Compaction System in Roll Compaction/Dry-Granulation, From Gerteis®. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 5(3), 1987–1994.

Gurpreet, Kaur, Sridhar, D. B., & Manoj Gera. (2012). Optimization of Roll Compaction / Dry Granulation (Rcdg) Process for Poorly Flowable Antiviral Formulation. Am. J. PharmTech Res., 2(4), 543–557.

Grulke, Ralf, Kleinebudde, Peter, & Shlieout, George. (2004). Mixture experiments on roll compaction. Pharm. Ind., 7(66), 911–915.

Chang, Ch. K., Alvarez–Nunez, F. A., Rinella Jr., J. V., Magnusson, L.-E., & Sueda, K. (2008). Roller Compaction, Granulation and Capsule Product Dissolution of Drug Formulations Containing a Lactose or Mannitol Filler, Starch, and Talc. AAPS PharmSciTech, 9(2), 597–604. doi: 10.1208/s12249-008-9088-y.

Heng, P. W. S., Chan, L. W., Liew, C. V., Chee, S. N., Soh, J. L. P., & Ooi, S. M. (2004). Roller compaction of crude plant material: influence of process variables, polyvinylpyrrolidone, and co-milling. Pharm. Dev. and Technol., 2(9), 135–144.

Heiman, J., Tajarobi, F., Gururajan, B., Juppo, A., & Abrahmsén-Alami, S. (2015). Roller Compaction of Hydrophilic Extended Release Tablets – Combined Effects of Processing Variables and Drug/Matrix Former Particle Size. AAPS PharmSciTech, 16(2), 267–277. doi: 10.1208/s12249-014-0219-3.

Jeon, I., Gilli, T. & Betz, G. (2011). Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets. J. Pharm. Bioallied Sci., 3(2), 213–220. doi: 10.4103/0975-7406.80771.

Sheskey, P., Pacholke, K., Sackett, G., Maher, L., & Polli, J. (2000). Roll compactiongranulation of a controlled release matrix tablet formulationcontaining HPMC: Effect of process scale-up on robustness of tablets,tablet stability and predicted in vivo performance. Pharm.Technol., 2(24), 30–52.

Gangurde, A., Patole R. K., Sav, A. K., & Amin, P. D. (2013). A Novel Directly Compressible Co-Processed Excipient for SustainedRelease Formulation. Journal of Applied Pharmaceutical Science, 3(9), 89–97. doi: 10.7324/JAPS.2013.3917.

Avinash Bhaskar Gangurde, & Purnima Dhanraj Amin (2013). Formulation development and evaluation of metformin hydrochloridesustained release matrix tabletby using directly compressible co-processed excipient. World Journal of Pharmacy and Pharmaceutical Sciences, 2(6), 5296–5308.

Lawrence Martin, Sandip B. Tiwari, & Ali Rajabi-Siahboomi. (2008). Use of Roller Compaction in the Preparation of Verapamil Hydrochloride Extended Release Matrix Tablets Containing Hydrophilic Polymers, CRS.

Lubrizol Advanced Materials Inc. (2011). Formulating Controlled Release Tablets and Capsules with Carbopol® Polymers. Pharmaceutical Bulletin, 31.

Mashutin, A. B. (2008). Razrabotka sostava, tekhnologii i biofarmacevticheskoe izuchenie tverdykh lekarstvennykh form indapamida (Avtoref. dis…kand. farm. nauk). [Development of composition, technology and biopharmaceutical study of solid dosage forms of indapamide] (Extended abstract of candidate’s thesis). Moscow. [in Russian].

Hariharan, M., Wowchuk, Ch., Nkansah, P., & Gupta, V. K. (2004). Effect of formulation composition on the properties of controlled release tablets prepared by roller compaction. Drug Dev. and Ind. Pharm., 6(30), 565–572.

Srikant, Pimple, Pravin, Maurya, Akash, Joshi, Mohan, Salunke, & Ruby, Singh. (2015). Formulation and evaluation of immediate release tablets of s (-) metoprolol succinate using roller compaction approach. World Journal of Pharmacy and Pharmaceutical Sciences, 4(07), 1551–1561.

Yue Teng, Zhihui Qiu, & Hong Wen. (2009). Systematical approach of formulation and process development using roller compaction. European Journal of Pharmaceutics and Biopharmaceutics, 73(2), 219–229. doi: 10.1016/j.ejpb.2009.04.008.

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How to Cite

1.
Tryhubchak OV, Groshovyj ТА, Yuryeva OО. The use of compaction in the manufacture of tablets. Current issues in pharmacy and medicine: science and practice [Internet]. 2016Jun.10 [cited 2024Nov.22];(2). Available from: http://pharmed.zsmu.edu.ua/article/view/71120

Issue

No. 2 (2016)

Section

Review

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