About standardization of L-lysinum 3-methyl-1,2,4-thiazolyl-5-thioacetate tablets

Authors

  • O. S. Bidnenko Zaporizhzhia State Medical University,
  • L. I. Kucherenko Zaporizhzhia State Medical University,
  • I. A. Mazur Zaporizhzhia State Medical University,
  • G. I. Tkachenko Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2409-2932.2016.2.70708

Keywords:

L-lysine-3-methyl-1, 2, 4-triazolyl-5-thioacetat, Quantitative Determination, Tablets, Spectrophotometry

Abstract

Ischemic heart disease is the leader of a sad medical statistics. According to official data, it is the most common disease on the planet. The majority of adults tend to it. Metabolic disorders are at the heart of pathological processes that develop in the myocardium during ischemia. Medicines that are able to interrupt or reduce the ischemic unfavorable metabolic reactions cascade, which are united as "metabolite tropic cardio protectors" exert a protective effect on the myocardium and have undoubted promise in clinical practice. The members of SPA "Farmatron" conducted targeted search of cardio protection drugs in a series of derivatives of 1,2,4-thiazolyl-5-thio carboxylic acids, which was finished by creation of L-lysiny 3-methyl-1,2,4-thiazolyl-5-thioacetate that shows cardio protective, antiischemic, antioxidant and pronounced effect on the vascular endothelium of brain and heart. Therefore, rational drug dosage form – tablet – is chosen for new drug. L-lysiny 3-methyl-1,2,4-thiazolyl-5-thioacetate is one of the metabolite tropic drugs that has properties of both direct and indirect cardio protectors. It is well known that medications for the treatment of cardiovascular disease in most cases should be used during a long time, and even lifelong. Therefore, rational drug dosage form – tablet – is chosen for new drug.

The aim of our study was to develop methods for standardization, including identification and quantitative determination of the active ingredient in the tablets obtained by spectrophotometric method.

Materials and methods. We investigated a tablet containing 200 mg of active ingredient obtained in the laboratory setting, and conducted six experiments. The study found that the active ingredient content is in the range of 0.2002 to 0.2016, spectrophotometric study results are consistent with the requirements of the State Pharmacopoeia of Ukraine.

Conclusions. Under the studies we developed a sensitive, objective, reliable, reproducible method for spectrophotometric determination of L-lysiny 3-methyl-1,2,4-thiazolyl-5-thioacetate.

References

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How to Cite

1.
Bidnenko OS, Kucherenko LI, Mazur IA, Tkachenko GI. About standardization of L-lysinum 3-methyl-1,2,4-thiazolyl-5-thioacetate tablets. Current issues in pharmacy and medicine: science and practice [Internet]. 2016Jun.10 [cited 2024Dec.23];(2). Available from: http://pharmed.zsmu.edu.ua/article/view/70708

Issue

No. 2 (2016)

Section

Analysis and standardization of biologycally active substances and dosage forms

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