About standardization of L-lysinum 3-methyl-1,2,4-thiazolyl-5-thioacetate tablet mass

Authors

  • O. S. Bidnenko Zaporizhzhia State Medical University,
  • L. I. Kucherenko Zaporizhzhia State Medical University,
  • I. A. Mazur Zaporizhzhia State Medical University,
  • G. I. Tkachenko Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2409-2932.2016.1.62011

Keywords:

L-lysine-3-methyl-1, 2, 4-triazolyl-5-thioacetat, Tablet Mass, Tablets, Spectrophotometry

Abstract

Aim. These days despite the constant efforts to optimize treatment of CNS and cardio - vascular system diseases the problem still remains unsolved. Taking into consideration the rising cost of medical care and accompanying social problems the development and launching of new approaches, methods and treatment regimens to increase clinical effectiveness of therapy are actual. L-lysinum-3-methyl-1,2,4-thiazolyl-5-thioacetate is the representative of metabolite drugs with marked effect on the endothelium of the brain and heart blood vessels. Cardioprotective properties of the medication are aimed to ameliorate the persistence of cardiomyocytes during acute myocardial ischemia and to improve the ECG measurements. It is well known that medications for the cardiovascular disease treatment in most cases should be used during a long time period, and even lifelong. Therefore, rational drug dosage form – tablet – has been chosen for new drug. It is also known that great attention in the production of tablets is paid to stepwise quality control.

 Methods and results. Therefore, the purpose of our study was the development of standardization methods of L-lysinum-3-methyl-1,2,4-triazolyl-5-thioacetatе in the tablet mass by spectrophotometry. During the work 6 series of L-lysinum-3-methyl-1,2,4-triazolyl-5-thioacetate tablet mass were studied.  

Conclusions. Thus, we established that all series meet the requirements of the State Pharmacopeia of Ukraine concerning the content of the active substance. Our research resulted in the development of a sensitive, objective, reliable and reproducible method of the spectrophotometric determination of L-lysinum-3-methyl-1,2,4-triazolyl-5-thioacetate in the tablet mass.

References

Georgievskij, G. V. (2011) Razrabotka kompleksa fiziko-khimicheskikh metodik, obespechivayuschikh sozdanie i kontrol' kachestva original'nykh otechestvennykh preparatov, proizvodnykh 1,2,4-triazola [Development of the complex physical and chemical methods, ensuring the creation and control of the quality of the original domestic products, 1,2,4-triazole]. Zaporozhskij medicinskij zhurnal, 13(1), 58–69. [in Ukrainian].

(2008) Derzhavna farmakopeia Ukrainy [State Ukrainian Pharmacopeia], (Ad. 2). Kharkiv. [in Ukrainian].

Kovalenko, V. N. (2012) (Ed.). Kompendium. Lekarstvennye preparaty 2012 [Compendium. Medicinal Preparations. 2012]. Kyiv: Morion. [in Ukrainian].

Kucherenko, L. I., Khromylova, O. V., Moriak, Z. B., Tkachenko, G. I., & Vaschenko, O. V. (2014) Shchodo postadiinoho kontroliu vyrobnytstva tabletok [Stage control of tablets manufacturing]. Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky, 2, 31–34. [in Ukrainian].

Mazur, I. A., Chekman, I. S., Belenichev, I. F., & Voloshin, N. A. (2007) Metabolitotropnye preparaty [Metabolitotropnye drugs]. Zaporozhye. [in Ukrainian].

Mazur, I. A, Belenichev, I. F., Kucherenko, L. I., Georgievskij, G. V., Chekman, I. S., Buchtiyarova, T. A., & Avramenko, N. A. (2012) Podhody k razrabotke i sozdaniyu metabolitotropnykh preparatov – proizvodnykh 1,2,4-triazola [Approaches to the development and creation of metabolitotropnyh drugs - derivatives of 1,2,4-triazole]. Nauchnye osnovy sozdaniya lekarstvennykh sredstv. Proceedings of the 12th scientific and practical seminar. Gurzuf. [in Ukrainian].

(2007) European Pharmacopoeia. Сouncil of Europe. Strasbourg.

Go A.S. Heart disease and stroke statistics 2013 update: a report from the merican Heart Association / Go A.S., Mozaffarian D., Roger V.L. et al. // Circulation. – 2013. – Vol. 127. – Р. e6–e245.

Ulu, S. T., & Elmali, F. T. (2010) Spectrophotometric method for the determination, validation, spectroscopic and thermal analysis of diphenhydramine in pharmaceutical preparation. Spectrochimica Acta Part A: Molecular and - Biomolecular

Spectroscopy, 77, 324–329. doi: 10.1016/j.saa.2010.05.031.

White, W. (2011) Blood pressure monitoring in cardiovascular medicine and therapeutscs. New Jersey: Humana Press.

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How to Cite

1.
Bidnenko OS, Kucherenko LI, Mazur IA, Tkachenko GI. About standardization of L-lysinum 3-methyl-1,2,4-thiazolyl-5-thioacetate tablet mass. Current issues in pharmacy and medicine: science and practice [Internet]. 2016Mar.9 [cited 2024Nov.23];(1). Available from: http://pharmed.zsmu.edu.ua/article/view/62011

Issue

No. 1 (2016)

Section

Analysis and standardization of biologycally active substances and dosage forms

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