Synthesis and physical-chemical properties of 3-benzyl-8-propylxanthine and its water-soluble salts

Authors

  • E. K. Mikhal’chenko Zaporizhzhia State Medical University,
  • K. V. Аleksandrova Zaporizhzhia State Medical University,
  • S. V. Levich Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2409-2932.2016.1.62005

Keywords:

Xanthines, Organic Synthesis, NMR-Spectroscopy

Abstract

Aim. Selection of basic compounds is a key moment of the novel drug substances development process. Nowadays, it is possible to model the properties of biologically active substances with the help of computer technologies and the special software. We selected 3-benzyl-8-propylxanthine as a promising basic compound with a large variability of further chemical modification by insertion of well-known pharmacophores. Our decision was based on in silico-calculations.

Materials and methods. This compound has been synthesized by condensation of 1-benzyl-5,6-diaminopyrimidine-2,4-dione with butanic acid. Then we obtained a number of water-soluble 3-benzyl-8-propylxanthinides-7 on the basis of initial substance. Synthesis has been made by reaction of 3-benzyl-8-propylxanthine with inorganic or organic bases in an aqueous or aqueous-alcoholic solution.

Conclusion. The structure of synthesized compounds has been proved using elemental analysis and 1H NMR-spectroscopy.

References

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How to Cite

1.
Mikhal’chenko EK, Аleksandrova KV, Levich SV. Synthesis and physical-chemical properties of 3-benzyl-8-propylxanthine and its water-soluble salts. Current issues in pharmacy and medicine: science and practice [Internet]. 2016Mar.9 [cited 2024Dec.25];(1). Available from: http://pharmed.zsmu.edu.ua/article/view/62005

Issue

No. 1 (2016)

Section

Synthesis of the biologically active compounds

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