Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts

Authors

  • A. S. Gotsulya Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2409-2932.2016.1.62003

Keywords:

xanthines, 1, 2, 4-triazole, physical and chemical properties

Abstract

1,2,4-Triazole derivatives are successfully used in medicine as antibacterial and antifungal agents.

Aim of our research is the study of synthesis of 7'-((3-thio-4-ethyl-4H-1,2,4-triazole-5-yl)methyl)-3'-methylxanthine.

Methods and results. Sodium salt of 3-methylxanthine has been used as the initial substance to obtain a new series of these compounds. It has been shown that the reaction of the corresponding hydrazide interaction with ethylisothiocyanate finds its continuation in the intramolecular cyclization. The synthesis of 2-(4-ethyl-5-((3'-methylxantine-7'-yl)methyl)-4Н-1,2,4-triazol-3-ylthio)аcetic acid’s salts has been performed. Physical-chemical properties of compounds have been researched and their structure and individuality has been confirmed by elemental analysis, IR-spectroscopy, 1H NMR-spectroscopy, chromato-mass and mass-spectrometry.

Conclusion. 12 New compounds have been obtained and their structure has been confirmed.

 

References

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How to Cite

1.
Gotsulya AS. Synthesis and research on properties of 2-(4-еthyl-5-((3’-methylxantine-7’-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts. Current issues in pharmacy and medicine: science and practice [Internet]. 2016Mar.9 [cited 2024Mar.28];(1). Available from: http://pharmed.zsmu.edu.ua/article/view/62003

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Section

Synthesis of the biologically active compounds