The study of UV-spectra of the sodium (3-oxo-3,4-dihydro-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetate

Authors

  • О. V. Kryvoshey Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2409-2932.2016.1.61437

Keywords:

Ultraviolet Spectrophotometry, Absorption, Electrons, Derivatives of [1, 2, 4]triazino[4, 3-c]quinazoline

Abstract

Despite the potential of [1,2,4]triazino[4,3-c]quinazoline derivatives as promising bioactive compounds, their electronic spectra has not been studied. Present manuscript is aimed to the estimation of relationships of molecules structure with the nature of their UV-spectra and identifying spectral patterns of pharmacophore that determines the pharmacological activity of the substance. Mentioned  information undoubtedly contributes to the development of the theory of the purposeful synthesis of organic compounds.

Methods and results. UV-spectra of sodium (3-oxo-3,4-dihydro-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetate in different polarity solvents have been studied. It allowed to identify types of electron transitions, which were responsible of emergence of the observed absorption bands.

Conclusions. It was found that the UV-spectra of the studied compounds in solvents with different polarity were characterized by three absorption bands in the range 190–227 nm, 260–284 nm and 328–348 nm. According to Braude classification the first absorption band should be classified as 1La, the second – as 1Lb, and the third band is due to p-π- conjugation in the molecule of the whole molecule structure.

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How to Cite

1.
Kryvoshey ОV. The study of UV-spectra of the sodium (3-oxo-3,4-dihydro-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetate. Current issues in pharmacy and medicine: science and practice [Internet]. 2016Mar.9 [cited 2024Mar.29];(1). Available from: http://pharmed.zsmu.edu.ua/article/view/61437

Issue

Section

Analysis and standardization of biologycally active substances and dosage forms