Analgesic activity of the salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid


  • V. M. Odintsova Zaporizhzhia State Medical University,



Analgesics, Adamantane, 1, 2, 4-triazole


Despite the varied approaches to the pain syndrome therapy with the changes and improvements of evolutionary medicine’s development and the drugs which are used to treat pain there are still considerable difficulties in solving this problem.

Aim. To detect compounds that are able to change the pain in experimental animals the action of salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid on central component of the nociceptive system has been studied in terms of thermal irritation of the extremities of rats.

Materials and results. First synthesized salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3- ylthio)acetic acid have been used in studies. Analgesic activity has been determined on «a hot plate» model, based on the ability of studied substances to change the pain threshold of experimental animals in comparison with control and expressed in percents. Analgin was used as the comparison drug at a dose of 1000 mg/kg (Analgin-Darnitsa, solution for injections, 500 mg/ml, 2 ml in ampules № 10).

Conclusions. The regularities between chemical structure and pharmacological action of 1,2,4-triazole derivatives have been determined. It testifies the prospects of further studies of salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid, as potential substances to create new drugs.


Anan'eva, L. P., & Balabanova, R. М. (2001). Lechenie anal'getikami central'nogo dejstviya khronicheskogo bolevogo sindroma pri zabolevaniyakh kostno-myshechnoj sistiemy [Treatment of chronic pain syndrome in diseases of musculoskeletal system by central acting analgesics]. Consilium medicum, 3(9), 428–432. [in Russsian].

Imametdinova, G. R., Chichasova, N. V., & Igolkina, E. V. (2013). Podhody k lecheniyu boli s uchetom mekhanizmov eyo razvitiya [Approaches to treating pain in terms of the mechanisms of its development]. Sovremennaya revmatologiya, 1, 59–65. [in Russsian].

Imametdinova, G. R., Chichasova, N. V., Nasonov, E. L., & Igolkina, E. V. (2010). Simptomaticheskaya terapiya khronicheskikh zabolevanij sustavov [Symptomatic therapy for chronic joint diseases]. Sovremennaya revmatologiya, 4, 66–70. [in Russsian].

Isakov, V. А. (2005). Gastropatiya, svyazannaya s priemom nesteroidnykh protivospalitel′nykh preparatov patogenez, lechenie, profilaktika [Gastropatia associated with non-steroidal antiinflammatory drugs: pathogenesis, treatment, prevention]. Klinicheskaya farmakologiya i terapiya, 14(2), 34–38. [in Russsian].

Lapach, S. N., Chubenko, А. V., & Babich, P. N. (2001) Statisticheskie metody v mediko-biologicheskikh issledovaniyakh s ispol′zovaniem Excel [Statistical methods in medic-biological researches, using Excel]. Кyiv: Моrion. [in Ukrainian].

Lebedeva, E. А., Belyaevskij, А. D., Zhitin, P. А., Belousova, M. E. & Dashevskij, S. P. (2012). K mekhanizmu realizacii antioksidantnykh e′ffektov nekotorykh nejroprotektorov [The implementation of mechanism of antioxidant effects of some neuroprotective agents]. Nervnye bolezni, 1, 29–33. [in Russsian].

Stefanov, А. V. (Ed) (2001). Metodychni vkazivky po do klinichnomu vyvchenniu likarskykh zasobiv [Methodical instructions in preclinical studying of drugs]. Кyiv. [in Ukrainian].

Morozova, E. А., Bolkunov, А. V., Dоlgikh, М. P., Tolstikova, T. G., Shul′c E′. E′. (2006). Novye perspektivnye anal′getiki [Promising new analgesics]. Biomedicina, 4, 98–99. [in Russsian].

Rebrova, О. Yu. (2002) Statisticheskij аnaliz medicinskikh dannykh. Primenenie paketa prikladnykh program STATISTICA [Statistical analysis of medical information. Using packet of the applied programs]. Мoskva: МеdiaSfera. [in Russsian].

Cliichasova, N. V., & Imametdinova, G. R. (2004). Preparat naiz (nimiesulid) v lechenii zabolevanij sustavov [Nise (Nimesulide) in treatment nf joint diseases]. Nauchno-prakticheskaya revmatologiya, 3, 34–36. [in Russsian].

Argoff, C. E. (2003) Topical analgesics: a review of recent clinical trials and their application to clinical practice. Advanced studies in medicine, 3, 642–647.

How to Cite

Odintsova VM. Analgesic activity of the salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid. Current issues in pharmacy and medicine: science and practice [Internet]. 2016Mar.9 [cited 2024Jun.21];(1). Available from:



Synthesis of the biologically active compounds