Acute toxicity of 5-(2-, 3-, 4-methoxyphenyl, (3,4,5-trimethoxyphenyl)-)-1,2,4-triazole-3-thiones and its thioderivatives

Authors

  • Yu. G. Samelyuk Zaporizhzhia State Medical University,
  • A. G. Kaplaushenko Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2409-2932.2015.3.52660

Keywords:

1, 2, 4-triazoles, Acute Toxicity Tests

Abstract

Aim. We have continued the study of 1,2,4-triazole derivatives,  which contain 2-, 3- , 4-methoxyphenyl or 3,4,5- methoxyphenyl substituents in 5th position of the triazole nucleus. An acute toxicity has been investigated for 11 eleven different classes of synthesized compounds based on heterocyclic triazole system.

Methods. Investigations have been carried out using white Wistar rats. Five groups of animals have been used to determine LD50 of 5-R-1,2,4-triazole-3-thiones and its derivatives.  Two observations have been set for each group using a previous dose and the next one. 

Conclusion. The obtained results show that LD50values of new 1,2,4-triazole-3-thiones derivatives which contain methoxyphenyl substituents in 5th position of the triazole nucleus, are in rage 304±65-1245±197 mg/kg. Investigated compounds are low-toxic or non-toxic substances according to Sidorov classification.

The presence and nature of substituents at the 1,2,4-triazole nucleus and nature of substituents connected with Sulfur in third position of 1,2,4-triazole nucleus affect the acute toxicity of 5-R-1,2,4-triazole-3-thiones and its derivatives.

References

Kaplaushenko, A. H. (2007) Budova ta hostra toksychnist amino- i tio- pokhidnykh 1,2,4-triazolu [Acute toxicity of amino- and tio-derivatives of 1,2,4-triazole]. Farmatsevtychnyi zhurnal. – 2007(1/40), 104–107. [in Ukrainian].

Kaplaushenko, A. G. (2010) Vzaiemozviazok mizh hostroiu toksychnistiu i doslidzhenymy vydamy farmakolohichnoi aktyvnosti 4-mono- i 4,5-dyzamishchenykh 1,2,4-triazol-3-tionu ta yikh S-pokhidnykh [Relationships between the acute toxicity and studied types of pharmacological activity parameters of the 4-mono- and 4,5-disubstituted 1,2,4-

triazole-3-thione and their thioderivatives]. Zaporozhskij medicinkij zhurnal, 12(4), 80–82. [in Ukrainian].

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Panasenko, O. I. (2005) Syntez, peretvorennia, fizyko-khimichni ta biolohichni vlastyvosti pokhidnykh 1,2,4-triazolu (Dis… dokt. farm. nauk). [Synthesis, transformation, physico-chemical and biological properties of derivatives of 1,2,4- triazoles. Dr. farm. sci. diss.]. Kyiv. [in Ukrainian].

Parchenko, V. V. (2006) Syntez, fizyko-khimichni ta biolohichni vlastyvosti 1,2,4-triazol-3-tioniv, shcho mistiat yadro furanu (Dis. kand. farm. nauk). [Synthesis, physico-chemical and biological properties of 1,2,4- triazoles -3- thiones containing core furan. Dr. farm. sci. diss.]. Kyiv. [in Ukrainian].

Sidorov, K. K. (1973) O klassifikacii toksichnosti yadov pri parenteral′nykh sposobakh vvedeniya [The classification of toxic poisons in the parenteral route of administration]. Toksikologiya novyh promyshlennykh veschestv, 13, 45–71. [in Russian].

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How to Cite

1.
Samelyuk YG, Kaplaushenko AG. Acute toxicity of 5-(2-, 3-, 4-methoxyphenyl, (3,4,5-trimethoxyphenyl)-)-1,2,4-triazole-3-thiones and its thioderivatives. Current issues in pharmacy and medicine: science and practice [Internet]. 2015Nov.3 [cited 2024Nov.23];(3). Available from: http://pharmed.zsmu.edu.ua/article/view/52660

Issue

No. 3 (2015)

Section

Experimental and clinical pharmacology

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