The development of liposomal medicine technology in a form of solution for injection

Authors

  • G. I. Borshchevskіy JSC «Farmak»,

DOI:

https://doi.org/10.14739/2409-2932.2015.3.52635

Keywords:

Essential Phospholipids, Liposomes, Technology, Solution, Injections

Abstract

Due to a number of important pharmacological effects, essential phospholipids today are widely used in medical practice.

Aim. In order to develop technology of liposomal for injections «Lesfal» a number of technological tasks at the stage of preparing the liposomes has been solved, namely, the optimal parameters for obtaining lipid film, providing uniform of liposome size, low impurity and alcohol content.

Methods and results. As a substance «Lipoid C 100» has been used. Determination of ethanol has been done by the method of gas chromatography, the determination of impurities (phosphatidylcholine and lysophosphatidylcholine) – by the method of liquid chromatography.

Conclusions. According to the research it has been found that the speed of rotation of the flask, the amount of feed solution of lipoid and deoxycholic acid affect the formation of impurities and ethanol content. The atmosphere, in which the formation of lipid film is done, influences the formation of impurities and almost do not influence on the amount of ethyl alcohol. The optimal loading of raw material is 10 % of the volume of the flask. The optimum rotational speed of the flask is 50 rev/min., the number of cycles of nitrogen is 4.

References

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Borschevskyi, H. I. (2013) Zastosuvannia metodu dyferentsiinoi skanuvalnoi kalorymetrii dlia vyznachennia yakosti filtratsii na prykladi preparatu «Lesfal» [Application of differential scanning calorimetry to determine the quality of filtration for example drug «Lesfal»]. Farmatsevtychnyi zhurnal, 4, 72–80. [in Ukrainian].

Borschevskyi, H. I. (2013) Faktory, yaki vplyvaiut na stabilnist preparatu Lesfal [Factors that affect the stability of the product Lesfal]. Upravlinnia, ekonomika ta zabezpechennia yakosti v farmatsii, 6(32), 10–14. [in Ukrainian].

Borschevskij, G. I., Omel′chenko, I. O., Skrynskij, V. S., & Shevina, V. L. (2014) Opredelenie dominiruyuschej modeli fil'tracii na primere preparata Lesfal' [Determination of the dominant model of filtering on the example of the preparation Lesfal]. Vestnik Farmacii, 1(63), 39–44. [in Belarus].

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How to Cite

1.
Borshchevskіy GI. The development of liposomal medicine technology in a form of solution for injection. Current issues in pharmacy and medicine: science and practice [Internet]. 2015Nov.3 [cited 2024Apr.26];(3). Available from: http://pharmed.zsmu.edu.ua/article/view/52635

Issue

No. 3 (2015)

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