Antibacterial and antifungal activity of derivatives 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole

Authors

  • O. A. Suhak Zaporizhzhia State Medical University,
  • O. І. Panasenko Zaporizhzhia State Medical University,
  • Ye. G. Knysh Zaporizhzhia State Medical University,
  • O. M. Kamyshny Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2409-2932.2015.3.52625

Keywords:

Anti-Microbial Agents, Antifangal Agents, 1, 2, 4-triazole

Abstract

The amount of antibiotics has increased over the past decade. This also resulted in increase of microorganisms’ resistance to this class of drugs. Therefore, the synthesis of new compounds that have exhibited antimicrobial and antifungal activity and low level of side effects is an important issue of modern pharmacy. The 1,2,4-triazole system is very promising in this aspect.

The aim was to study the antimicrobial and antifungal activity of 4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol and 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole.

 Methods and results. In the study "serial dilutions" method has been used. The criteria for the activity of given compound was the minimum inhibitory concentration (MIC) which is the lowest concentration of drug that inhibits the growth of the test culture and the minimum bactericidal concentration (MBC) which is the lowest concentration of drug that causes bactericidal effect. Test compounds are derivatives of 4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol and 3-(alkyl-thio)-4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole which exhibit antifungal and antimicrobial activity.

Conclusion. The most active of the studied 1,2,4-triazole derivatives is 4 (4-methyl-3-(octylthio)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole), which manifests as antifungal and antimicrobial activity. Some regularity between structure and action has been investigated.

References

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How to Cite

1.
Suhak OA, Panasenko OІ, Knysh YG, Kamyshny OM. Antibacterial and antifungal activity of derivatives 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole. Current issues in pharmacy and medicine: science and practice [Internet]. 2015Nov.3 [cited 2024Nov.23];(3). Available from: http://pharmed.zsmu.edu.ua/article/view/52625

Issue

No. 3 (2015)

Section

Experimental and clinical pharmacology

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