Diuretic activity of 3-(5-bromfuran-2-yl)-4-r-(4h)-1,2,4-triazole-5-thione, their S-derivatives and 2-(5-bromfuran-2-yl)-5-r'-thiazolo[3,2-b][1,2,4]triazole-6(5h)-ones

Authors

  • Ye. S. Pruglo Zaporizhzhia State Medical University,
  • A. S. Gotsulya Zaporizhzhia State Medical University,
  • O. I. Panasenko Zaporizhzhia State Medical University,
  • Ye. G. Knysh. Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2409-2932.2015.3.52274

Keywords:

Diuretic Effect, 1, 2, 4-triazole, Side Effects, Adverse Reactions

Abstract

The aim of study was to investigate diuretic activity of 1,2,4-triazole derivatives which contain С5 atom 5-bromfuran-2-yl substituent in the 1,2,4-triazole nucleus, and to establish interrelation between chemical structure and diuretic action of 1,2,4-triazole derivatives.

Methods and results. For the investigation of the diuretic activity were used 15 compounds, namely 3-(5-bromofuran-2-yl)-4-R-(4H)-1,2,4-triazole-5-thiones, their S-derivatives and 2-(5-bromofuran-2-yl)-5-R'-thiazolo[3,2-b][1,2,4]triazole-6(5H)-ones. During the study Ye. B. Berkhin’s method has been used to establish the influence of the compounds on the renal excretory function.

Conclusion. The most active substance among 1,2,4-triazole derivatives was morpholinium 2-((5-bromofuran-2-yl)-4-ethyl-1,2,4-triazole-3-ylthio)acetate.

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How to Cite

1.
Pruglo YS, Gotsulya AS, Panasenko OI, Knysh. YG. Diuretic activity of 3-(5-bromfuran-2-yl)-4-r-(4h)-1,2,4-triazole-5-thione, their S-derivatives and 2-(5-bromfuran-2-yl)-5-r’-thiazolo[3,2-b][1,2,4]triazole-6(5h)-ones. Current issues in pharmacy and medicine: science and practice [Internet]. 2015Nov.3 [cited 2024Nov.23];(3). Available from: http://pharmed.zsmu.edu.ua/article/view/52274

Issue

No. 3 (2015)

Section

Synthesis of the biologically active compounds

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