Effectiveness of using Glutamyl-cysteinyl-glycine disodium immunomodulator in patients with destructive multidrug-resistant tuberculosis of lungs
DOI:
https://doi.org/10.14739/2409-2932.2015.2.45196Keywords:
Immunomodulator, Multidrug-Resistant TuberculosisAbstract
Importance of the problem: treatment efficiency improving in patients with multidrug-resistant destructive pulmonary tuberculosis (MDR).
Aim. To study the complex treatment effectiveness in patients with destructive MDR with implementation of Glutamyl-cysteinyl-glycine disodium (GCGD) immunomodulator.
Methods and results. On the basis of standard chemotherapy course main treatment effectiveness parameters have been estimated of 30 patients who were treated with implementation of GCGD on the basis of standard chemotherapy course and 30 patients who were treated with standard chemotherapy course alone.
Conclusion. Complex treatment of patients with destructive MDR with implementation of GCGD immunomodulator on the basis of standard chemotherapy course for immunity state correction allows to increase effectiveness of treatment by 33,3%.
References
Dmitriev, V. A. (2008) Global problem of tuberculosis and modern WHO strategy to combat it. Antibiotics and chemotherapy, 5-6, 3-6. [in Russian].
Cherenko, S. A. Problem multidrug-resistant tuberculosis tuberculosis. Access: http://www.ifp.kiev.ua/doc/ people / tubrezist.htm. [in Russian].
Feschenko, Y. I. (2011). Antibiotic resistance of microorganisms. State the problem and ways to solve. Ukrainian Pulmonology Journal, 4, 41-43. [in Russian].
Mishin, V. Yu., Komissarov, O. G., Chukanov, V. I. & Kononets, A. (2009). Peculiarities of the process and the effectiveness of the treatment of patients with pulmonary tuberculosis, Mycobacterium tuberculosis excreting with extensive drug resistance to anti-TB drugs. Problems of tuberculosis, 2, 50-52. [in Russian].
Platonov, I. L., Weaver, O. A., Sahelashvili, M. I., Schurko, G. V., Lapovets, N. E. & Shtybel, G. D. (2011). Evaluation of antimycobacterial therapy in patients with pulmonary tuberculosis on indicators of immunological research. Tuberculosis, pulmonary disease, HIV infection, 2, 21-25. [in Russian].
Chernushenko, E. F. & Protsiuk, R. G. (2010). Аntituberculous immunity (Part I). Ukrainian Pulmonology Journal, 4, 53-58. [in Russian].
Chernushenko, E. F. & Protsiuk, R. G. (2011). Аntituberculous immunity (Part II). Ukrainian Pulmonology Journal, 1, 29-32. [in Russian].
Feschenko, Yu. I., Yschuk, S. G. & Matvyenko, A. (2012). Therapeutic opportunities of innovative immunmodulator in pulmonology and phthisiology. Ukrainian Pulmonology Journal, 3, 50-54. [in Russian].
Balasanyants, G. S. & Sukhanov, D. S. (2011). Some aspects of pathogenetic therapy for tuberculosis in modern conditions. Therapeutic rchive, 8, 21-24. [in Russian].
Antushevich, A. E., Antonov, V. G., Vasilenko, K. P. & Burov, E. B. (2005). A possible mechanism for eliminating antibiotic resistance of Mycobacterium tuberculosis glutoxim. First All-Russian Scientific Forum "Innovative Technologies in Medicine XXI century": Collection mes, 405-407. [in Russian].
Peresi, E., Silva, S. M. & Calvi, S. A. (2008). Cytokines and acute phase serum proteins as markers of inflammatory regression during the treatment of pulmonary tuberculosis Jornal Brasileiro de Pneumologia, 11, 942-949.
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