The study of reactions of 7-substituted 8-hydrazino-3-methylxanthine with β-dicarbonyl compounds

Authors

  • N. I. Romanenko
  • M. V. Nazarenko
  • D. G. Ivanchenko
  • O. O. Pakhomova
  • T. A. Sharapova

DOI:

https://doi.org/10.14739/2409-2932.2015.2.45125

Keywords:

Xanthine, Organic Synthesis, NMR-spectroscopy, Mass Spectrometry

Abstract

The problem of searching biologically active compounds amidst xanthine derivatives is a crucial one and is an issue for long-term investigation.

The aim of this paper was to study reactions of 7-substituted 8-hydrazino-3methylxanthine with acetylacetone and acetoacetic ether.

Methods and results. Reaction of 7-substituted 8-hydrazinoxanthines together with acetylacetone is performed by way of forming the respective 7-substituted 8-(3,4-dimethylpyrazole-1-yl)-3-methylxanthines.

Interaction of hydrazinoxanthines with the excess of acetoacetic ether proceeds with the formation of 8-(3,4-dimethyl-6-oxopyrano[2,3-s]pyrazol-1-yl)xanthines.

Conclusion. The investigated spectral characteristics of synthesized compounds indicate of relevance of IR-, NMR- and mass spectra to the proposed structure –(3,4-dimethyl-6-oxopyrano[2,3-s]pyrazol-1-yl)xanthines and 7-substituted 8-(3,4-dimethylpyrazole-1-yl)-3-methylxanthine.

 

References

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How to Cite

1.
Romanenko NI, Nazarenko MV, Ivanchenko DG, Pakhomova OO, Sharapova TA. The study of reactions of 7-substituted 8-hydrazino-3-methylxanthine with β-dicarbonyl compounds. Current issues in pharmacy and medicine: science and practice [Internet]. 2015Jul.14 [cited 2024Mar.28];(2). Available from: http://pharmed.zsmu.edu.ua/article/view/45125

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Section

Synthesis of the biologically active compounds