Substantiation of the active ingredients rational concentration of ointment for treatment of allergic dermatitis complicated by fungal infection

Authors

  • O. A. Rukhmakova
  • T. G. Yarnykh
  • L. N. Maloshtan
  • E. Yu. Yatsenko
  • Esam Zurgani A. Zegkhdani

DOI:

https://doi.org/10.14739/2409-2932.2015.2.45113

Keywords:

Ointment, Chemical Actions and Uses, Dermatitis, Mycoses

Abstract

Aim. Due to the rapid growth of number of allergic skin diseases complicated by secondary fungal infection, creation of new drugs with an integrated anti-allergic and anti-fungal action for their local treatment is especially important.

Methods and results. In the process of developing an ointment under conventional name “Allergolik” microbiological studies have been conducted to determine its rational composition. Concentrations of licorice root extract, terbinafine hydrochloride and lavender essential oil have been substantiated as parts of the studied medication. Study of acute toxicity of the developed dosage form has set that it belongs to the IV class of low-toxic substances due to the standard classification of K.K. Sidorova.

Conclusion. This testifies the correctness of the choice of drug active ingredients and their concentrations.

References

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How to Cite

1.
Rukhmakova OA, Yarnykh TG, Maloshtan LN, Yatsenko EY, Zegkhdani EZA. Substantiation of the active ingredients rational concentration of ointment for treatment of allergic dermatitis complicated by fungal infection. CIPM [Internet]. 2015Jul.14 [cited 2023Dec.10];(2). Available from: http://pharmed.zsmu.edu.ua/article/view/45113

Issue

No. 2 (2015)

Section

Experimental and clinical pharmacology

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