Substantiation of the active ingredients rational concentration of ointment for treatment of allergic dermatitis complicated by fungal infection

Authors

  • O. A. Rukhmakova
  • T. G. Yarnykh
  • L. N. Maloshtan
  • E. Yu. Yatsenko
  • Esam Zurgani A. Zegkhdani

DOI:

https://doi.org/10.14739/2409-2932.2015.2.45113

Keywords:

Ointment, Chemical Actions and Uses, Dermatitis, Mycoses

Abstract

Aim. Due to the rapid growth of number of allergic skin diseases complicated by secondary fungal infection, creation of new drugs with an integrated anti-allergic and anti-fungal action for their local treatment is especially important.

Methods and results. In the process of developing an ointment under conventional name “Allergolik” microbiological studies have been conducted to determine its rational composition. Concentrations of licorice root extract, terbinafine hydrochloride and lavender essential oil have been substantiated as parts of the studied medication. Study of acute toxicity of the developed dosage form has set that it belongs to the IV class of low-toxic substances due to the standard classification of K.K. Sidorova.

Conclusion. This testifies the correctness of the choice of drug active ingredients and their concentrations.

References

Haitov, R. M., & Il'ina, N. I. (Eds.) (2009). Allergologiya i immunologiya: nacional'noe rukovodstvo [Allergy and Immunology: national leadership]. Moscow: GEOTAR-Media. [in Russian].

Rieznіchenko, N. Yu. (2013). Alerhіchnyi kontaktnyi dermatyt: suchasnі uiavlennia pro lіkuvannia na osnovі ohliadu naukovoi lіteratury [Allergic contact dermatitis: current understanding of treatment based on a review of scientific literature]. Aktualnі pytannia farmatsevtychnoi і medychnoi nauky ta praktyky, 3(13), 69–72. [in Ukrainian].

Tanei, R., & Katsuoka, К. (2008). Clinical analyses of atopic dermatitis in the aged. J. Dermatol, 35, 562–569. doi: 10.1111/j.1346-8138.2008.00524.x.

Kogan, B. G., & Verba, Ye. A. (2013). Novye evropejskie podkhody v terapii rezistentnykh form allergodermatozov [New European approaches in the treatment of resistant forms of allergic dermatitis]. Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii, 1(48), 137–143. [in Ukrainian].

Sehgal, V. N., Srivastava, G., & Dogra, S. (2010). Atopic dermatitis: current options and treatment plan. Skinmed, 8(6), 335–344.

Kovalenko, V. N. (Ed.) (2012). Kompendium 2012 – lekarstvennye preparaty [Compendium 2012 – medicines]. Kyiv: Morion. Retrieved from http://compendium.com.ua. [in Ukrainian].

Tolstikov, G. A., Shults, E. E., & Baltina L. A. (1997). Glicirrizinovaya kislota [Glycyrrhizic acid]. Bioorganicheskaya khimiya, 23(9), 691–709. [in Russian].

Fedoseeva, G. M., Goryachkina, E. G., & Mirovich, V. M. (2011). Lekarstvennye sredstva iz rastenij (ukazatel') [Medicines from plants (pointer)]. Irkutsk: ISMU. [in Russian].

Bolotnaya, L. A. (2012). Rol' terbinafina v terapii gribkovykh porazhenij kozhi [The role of terbinafine in the treatment of fungal infections of the skin]. Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii, 4(47), 108–115. [in Ukrainian].

Lamrini, M., Kurkin, V. A., Mizina, P. G., Belyaeva, M. V., Arutyunov, Yu. I., & Onychak, L. A. (2008). Flavonoidy i terpenoidy cvetkov lavandy kolosovoj [Flavonoids and terpenoids lavender flowers]. Himiya rastitel'nogo syr'ya, 1, 77–80. [in Russian].

Downloads

How to Cite

1.
Rukhmakova OA, Yarnykh TG, Maloshtan LN, Yatsenko EY, Zegkhdani EZA. Substantiation of the active ingredients rational concentration of ointment for treatment of allergic dermatitis complicated by fungal infection. Current issues in pharmacy and medicine: science and practice [Internet]. 2015Jul.14 [cited 2024Nov.24];(2). Available from: http://pharmed.zsmu.edu.ua/article/view/45113

Issue

No. 2 (2015)

Section

Experimental and clinical pharmacology

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.     Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)