The acute toxicity of 5-thio-substituted 3-(5-bromofuran-2-yl)-4-ethyl-(4H)-1,2,4-triazole derivatives
DOI:
https://doi.org/10.14739/2409-2932.2015.2.45112Keywords:
Acute Toxicity Test, 1, 2, 4-triazole, Pharmaceutical Preparations, Lethal Dose 50Abstract
Aim. Research of the acute toxicity of new compounds could prevent the development of compounds with high pharmacological activity, which exhibit undesirable pharmacological properties. Therefore, on the first stages of research the study of the acute toxicity of new compounds is quite actual.
Methods and results. For further research of the pharmacological properties of the synthesized compounds the acute toxicity of 5-thio-substituted 3-(5-bromofuran-2-yl)-4-ethyl-(4H)-1,2,4-triazole derivatives has been examined on white nonlinear rats by V. B. Prozorovskiy method (2007). The comparative evaluation of researched parameters for newly synthesized 3-(5-bromofuran-2-yl)-4-ethyl-4H-1,2,4-triazole-5-thione derivatives and already applicable drugs, which are 1,2,4-triazole derivatives has been performed.
Conclusion. It has been established that the acute toxicity of the test compounds is in the ranges from 331 to 713 mg/kg, which indicates their low toxicity and classifies them to the IV-th class of toxicity.
References
Kurlyandskij, B. A., & Filatova, V. A. (2002) Obshchaya toksikologiya [General Toxicology]. Moscow: Medicina. [in Russian].
Gallo, M. A., & Doull, J. (1991). History and Scope of Toxicology. The Basic science of poisons. Casarctt and Doulls Toxicology: The Basic science of poisons. M.O. Amdur, J. Doull, C.E. Klassen (Eds), (P. 3–11). New York.
Sanockij, I. V. (Ed). (1970). Metody opredeleniya toksichnosti v opasnosti khimicheskikh veshchestv (toksikometriya) [Methods for determination of toxicity and hazards of chemicals (Toximeter)]. Moscow: Medicina [in Russian].
Stefanov, O. V. (2001). Doklinichni doslidzhennya likarskykh zasobiv [Preclinical studies of drugs]. Kyiv: Avitsena. [in Ukrainian].
Prozorovskii, V. B. (2007) Statisticheskaya obrabotka rezul`tatov farmakologicheskikh issledovanij [Statistic processing of data of pharmacological investigations]. Psikhofarmakologiya i biologicheskaya narkologiya, 7(3), 2090–2120. [in Russian].
Material safety data sheet Retrieved from http://www.pfizer.com/files/products/material_safety_data/PZ01527.pdf
Material safety data sheet Retrieved from http://www.bausch.com/portals/109/-/m/BL/United%20States/Files/MSDS/reveyesmsds.pdf
Material safety data sheet Retrieved from http://img1.guidechem.com/msdspdf/66535-86-2.pdf
Material safety data sheet Retrieved from http://www.chemcas.com/msds/cas/msds136/85815-37-8.asp
Material safety data sheet Retrieved from http://www.usp.org/pdf/EN/referenceStandards/msds/1356971.pdf
Material safety data sheet Retrieved from http://www.pfizer.com/files/products/material_safety_data/132.pdf
Material safety data sheet Retrieved from https://www.spectrumchemical.com/MSDS/TCI-I0732.pdf
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
