Synthesis and physical-chemical properties of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its s-substituted derivatives

Authors

  • K. V. Аleksandrova
  • A. S. Shkoda
  • S. V. Levich
  • M. V. Dyachkov
  • D. M. Yurchenko

DOI:

https://doi.org/10.14739/2409-2932.2015.2.45108

Keywords:

Xanthines, Organic Synthesis, Infrared-Spectroscopy, NMR-spectroscopy

Abstract

Aim. Currently, researches, devoted to obtain new active compounds, are carried out among various classes of organic compounds, and combination of several active heterocyclic fragments in one molecule is considered the key way in such researches.

Methods and results. For this purpose, we have developed a preparative method of synthesis of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its S-substituted derivatives. On example of propyl ester of [5-(3-benzylxanthinyl-8-methylthiomethyl)-4-phenyl-[1,2,4]triazole-3-yl]thioacetic acid the possibility of further functionalization of triazolylmethylthiomethylxanthines has been shown.

Conclusion. The structures and identity of all synthesized compounds have been proved by elemental analysis, IR-, 1H NMR-spectroscopy, mass-spectrometry and by thin layer chromatography.

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How to Cite

1.
Аleksandrova KV, Shkoda AS, Levich SV, Dyachkov MV, Yurchenko DM. Synthesis and physical-chemical properties of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its s-substituted derivatives. Current issues in pharmacy and medicine: science and practice [Internet]. 2015Jul.14 [cited 2024Nov.25];(2). Available from: http://pharmed.zsmu.edu.ua/article/view/45108

Issue

No. 2 (2015)

Section

Pharmacognosy and chemistry of natural compounds

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