Clinical features of coronary heart disease in postmenopausal women, depending on the degree of bone mineral density loss

Authors

  • N. S. Mykhailovskaya
  • I. O. Shevchenko
  • O. V. Nikituk

DOI:

https://doi.org/10.14739/2409-2932.2015.2.45106

Keywords:

Coronary Artery Disease, Postmenopausal Period, Osteoporosis, Osteopenia, Bone Mineral Density, Correlation Of Data

Abstract

Coronary artery disease (CAD) is one of the most urgent problems of the modern cardiology.

Aim. In order to explore the clinical features of the coronary artery disease, depending on the degree of bone mineral density loss the study included 43 women in postmenopausal period.

Methods and results. Group 1 - 10 patients with coronary artery disease concomitant with osteopenia, 2 group- 12 CAD patients with osteoporosis; Group 3 (comparisons) - 21 CAD patients with normal BMD. With the help of ultrasound densitometry, echocardioscopy, Seattle Angina Questionnaire we investigated the BMD state, structural and functional state of the heart, life quality of the patients. It has been found that the coronary artery disease concomitant with the osteopenic syndrome is characterized by lipid shift towards pro-atherogenic fractions, reduced quality of life according to Seattle Angina Questionnaire, more frequent development of diastolic dysfunction, calcification of the heart valves and large vessels.

Conclusion. The correlation relationship with the T-score as the main parameter of the degree of the bone mineral density loss has been determined. 

References

Horbas, I. M. (2009). Ishemichna khvoroba sertsia: epidemiolohiia i statystyka [Coronary heart disease: epidemiology and statistics]. Zdorovia Ukrainy. (3), 34–35.

Ershova, O. B., Nazarova, A. V., Belova, K. Yu. (2009). Patogeneticheskaya svyaz' serdechno-sosudistoy patologii i osteoporoza u patsientov starshikh vozrastnykh grupp : obzor lit. [Patogeneticheskaya communication of cardiovascular pathology and osteoporosis at patients of the senior age groups: review]. Osteoporoz i osteopatii. (2), 21–27.

Barna, O. M. Yarema, N. I., Bazylevych, A. Ya. (2009). Patofiziolohichni ta klinichni paraleli IKhS ta osteoporozu [Pathophysiological and clinical coronary heart disease and osteoporosis parallel].(3,129), 43–46.

Gavisova, A. A., Tverdikova M. A., Yakushevskaya O. V. (2012). Osteoporoz: sovremennyy vzglyad na problemu [Osteoporoz: a modern view on a problem]. Rus. med. zhurn. : Akusherstvo i ginekologiya (29), 1110.

Vertkin, A. L., Naumov, A. V., Goruleva, E. I., Adonina, E. V., Skotnikov, A. S., Shakirova, S. R., Zaichenko, D. M., Vladimirova, N. N.(2012). Osteoporoz kak komponent serdechno-sosudistogo kontinuuma [Elektronnyy resurs] [Osteoporosis as component of a cardiovascular continuum [An electronic resource]. Lechashchiy vrach, (02), http://www.lvrach.ru/2012/02/15435341.

Karpova, I. S., Manak, N. A., Koshlataya, O. V., Solovey, S. P., Matskevich (2012). Vzaimosvyaz' mineral'noy plotnosti kostey, lipidnogo obmena i endotelial'noy funktsii u zhenshchin s IBS i postmenopauzal'nym osteoporozom [Elektronnyy resurs] [Interrelation of mineral density of bones, a lipidic exchange and endotelialny function at women with IBS and post-menopausal osteoporosis [An electronic resource] Bol'. Sustavy. Pozvonochnik. (4,(08), Access mode: http://www.mif-ua.com/archive/article/34605.

Karpova, I. S. (2012). Vzaimosvyaz' kal'tsinoza arteriy i klapannogo apparata serdtsa i osteoporoza [Vzaimosvyaz of a kaltsinoz of arteries and the valvate device of heart and Osteoporosis]. Kardiologiya v Belarusi. (1), 98–103.

Osteoporosis and Cardiovascular Risk Among Premenopausal Women in Sri Lanka / Lekamwasam S., Weerarathna T., Rodrigo M. [et al.] //J. Clin. Densitom. – 2009. – Vol. 12, issue 2. – P. 245–250.

Nowicka G. Coronary heart disease and osteoporosis:factors related to development of both diseases/ Nowicka G., Panczenko-Kresowska B. // Przegl. Lek. – 2007 – Vol. 64 (3). – P. 153–158.

Coronary calcification and osteoporosis in men and postmenopausal women are independent processes associated with aging / Sinnott B., Syed I., Sevrukov A., Barengolts E. // Calcif. Tissue. Int. – 2006. – № 78 (4). – P. 195–202.

Karwowski, W., Naumnik, B., Szczepański, M., Myśliwiec, M. (2012). The mechanism of vascular calcification : a systematic review. Med Sci Monit. (18,1), RA1-11.

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How to Cite

1.
Mykhailovskaya NS, Shevchenko IO, Nikituk OV. Clinical features of coronary heart disease in postmenopausal women, depending on the degree of bone mineral density loss. Current issues in pharmacy and medicine: science and practice [Internet]. 2015Jul.14 [cited 2024Nov.24];(2). Available from: http://pharmed.zsmu.edu.ua/article/view/45106

Issue

No. 2 (2015)

Section

Experimental and clinical pharmacology

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