Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets
DOI:
https://doi.org/10.14739/2409-2932.2023.3.287001Keywords:
parsnips, plant extracts, excipients, composition, pharmacy technology, tabletsAbstract
The aim of the work is to justify the choice of excipients as components for the cardioprotective medicine “Pastinocard” tablets based on the domestic raw material of cultivated parsnip herb thick extract (CPHTE).
Materials and methods. Experimental test samples of mixtures of the plant substance of domestic origin CPHTE with groups of excipients, approved for medical use, were used as the object of research.
Results. We conducted experimental research by a mathematical planning method called the Greek–Latin square. In this study, we investigated how 16 different auxiliary substances affected the pharmacotechnological properties of tableting masses and tablets made from PPTEG with cardioprotective properties. Our goal was to determine the optimal composition and manufacturing process for a medication, specifically “Pastinocard” tablets. We also developed project plans for manufacturing regulations and quality control methods, which we successfully tested in the industrial production setting at Pharmaceutical Company “Zdorovye”, LTD in Kharkiv.
Conclusions. The formulation for cardioprotective tablets, designated as “Pastinocard”, has been both theoretically justified and experimentally developed by domestic CPHTE raw materials. These research findings have been instrumental in crafting the regulatory documentation for quality control and the production processes of the resulting tablet medication.
References
Kamarudin, N. A., Markom, M., & Latip, J. (2016). Effects of solvents and extraction methods on herbal plants Phyllanthus niruri, Orthosiphon stamineus and Labisia pumila. Indian Journal of Science and Technology, 9(21). https://doi.org/10.17485/ijst/2016/v9i21/95235
Symonenko, N., Shpychak, O., Mishchenko, O., Kyslychenko, V., Shpychak, T., & Graschenkova, S. (2022). Antioxidant and anti-cytolytic activity of Parsnip (Pastinaca sativa L.) herb thick extract in conditions of catecholamine myocardiodystrophy in rats. ScienceRise: Pharmaceutical Science, 35(1), 70–76. https://doi.org/10.15587/2519-4852.2022.253546
Farjadmand, F., Khanavi, M., Eftekhari, M., Hosseinsalari, A., Akbarzadeh, T., Safavi, M., Asatouri R., Mirabzadeh M., & Shams, M. (2018). The effect of extraction method on the major constituents and biological effects of Trachyspermum ammi L. fruits. Research Journal of Pharmacognosy, 5(1), 55–61. Retrieved from https://www.rjpharmacognosy.ir/article_54433.html
Symonenko, N. A., Shpychak, O. S., Slipchenko, H. D., & Ruban О. А. (2021). Obgruntuvannia vyboru dopomizhnykh rechovyn dlia stvorennia tabletok na osnovi pasternaku posivnoho travy ekstraktu hustoho [Justification for the choice of excipients in the creation of tablets based on pasternax of seeding thick extract]. Ukrainskyi zhurnal viiskovoi medytsyny, 2(4), 149-160. [in Ukrainian]. https://doi.org/10.46847/ujmm.2021.4(2)-149
Shymorova, Yu. Ye., & Kyslychenko, V. S. (2020). Protyzapalnyi zasib na osnovi pasternaku posivnoho [Anti-inflammatory agent based on parsnip]. Ukraine Patent UA 139957. https://sis.nipo.gov.ua/uk/search/detail/1412590/
Symonenko, N. A., Shpychak, O. S., & Bezrukavyi, Ye. A. (2023). Rozrobka promyslovoi tekhnolohii tabletok kardioprotektornoi dii na osnovi pasternaku posivnoho travy ekstraktu hustoho [Development of industrial technology of tablets with cardioprotective action based on cultivated parsnip herb thick extract]. Current issues in pharmacy and medicine: science and practice, 16(1), 33-39. https://doi.org/10.14739/2409-2932.2023.1.264981
Kukhtenko, O. S., Hladukh, Ye. V. (2019). Razrabotka sostava tabletok Kardiosten s ispolzovaniem metoda matematicheskogo planirovaniya eksperimenta [Development of the composition of the tablets "Cardiosten" using the method of mathematical planning of the experiment]. Current issues in pharmacy and medicine: science and practice, 12(2), 166-171. [in Ukrainian]. https://doi.org/10.14739/2409-2932.2019.2.170988
State Enterprise Ukrainian Scientific Pharmacopoeial Center of Medicines Quality. (2015). Derzhavna Farmakopeya Ukrayiny [The State Pharmacopoeia of Ukraine] (Vol. 1, 2nd ed.). Kharkiv: State Enterprise Ukrainian Scientific Pharmacopoeial Center of Medicines Quality. [in Ukrainian].
Ministry of Health of Ukraine. (2020). Guidelines ST-N MOH 42 4.0: 2020 "Medicines. Good manufacturing practice". [in Ukrainian]. Retrieved from https://www.dls.gov.ua/wp-content/uploads/2020/05/%D0%9D%D0%B0%D1%81%D1%82%D0%B0%D0%BD%D0%BE%D0%B2%D0%B0-%D0%A1%D0%A2-%D0%9D-%D0%9C%D0%9E%D0%97%D0%A3-42-4.0_2020.pdf
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
