Results of a clinical trial of humeral neck osteosynthesis with carbon – carbon composite material

Authors

DOI:

https://doi.org/10.14739/2409-2932.2023.3.286567

Keywords:

osteosynthesis fracture, shoulder fractures, bone plates, surgery treatment

Abstract

The metals utilized in the production of various implants in traumatology possess all the required mechanical properties. However, these materials are susceptible to oxidation. Carbon-carbon composites, on the other hand, exhibit X-ray transparency and are easily machinable. Thanks to their intricate yet essential physical, mechanical, and chemical properties, they find effective application in osteosynthesis and endoprosthesis procedures for bone structures.

The aim of this study is to comparative view of the treatment outcomes for patients with fractures of the proximal part of the humerus by carbon-carbon composite material plates and titanium plates.

Materials and methods. In this study, a carbon-carbon composite material plate was conducted osteosynthesis of the proximal part of the shoulder. In the comparison group, a titanium plate was employed. The study group comprised 20 patients, while the comparison group included 15 patients. The analysis of the results was carried out utilizing the Constant–Murley scale and the Quick DASH questionnaire.

Results. A comparative study of treatment outcomes between the main and comparison groups revealed a more significant positive treatment effect in the group that underwent osteosynthesis of the humeral neck by a carbon-carbon composite material plate. This effect was observed at the 3-month, 6-month, and 12-month evaluation points. It was characterized by reduced shoulder pain, alleviated dysfunction manifestations, enhanced daily activities, and improved overall quality of life among patients in this group.

Conclusions. The analysis of long-term treatment outcomes for proximal humerus fractures, utilizing both carbon-carbon composite material plates and titanium plates, by the Constant–Murley scale and the Quick DASH questionnaire, demonstrated statistically confirmed improvements in shoulder joint function for both treatment methods.

Author Biographies

M. L. Golovakha, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Traumatology and Orthopedics

V. V. Chornyi , Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

MD, Assistant of the Department of Traumatology and Orthopedics

References

Mînzatu, V., Davidescu, C. M., Negrea, P., Ciopec, M., Muntean, C., Hulka, I., Paul, C., Negrea, A., & Duțeanu, N. (2019). Synthesis, Characterization and Adsorptive Performances of a Composite Material Based on Carbon and Iron Oxide Particles. International journal of molecular sciences, 20(7), 1609. https://doi.org/10.3390/ijms20071609

Delaney, F. T., Denton, H., Dodds, M., & Kavanagh, E. C. (2021). Multimodal imaging of composite carbon fiber-based implants for orthopedic spinal fixation. Skeletal radiology, 50(5), 1039-1045. https://doi.org/10.1007/s00256-020-03622-6

Cofano, F., Di Perna, G., Monticelli, M., Marengo, N., Ajello, M., Mammi, M., Vercelli, G., Petrone, S., Tartara, F., Zenga, F., Lanotte, M., & Garbossa, D. (2020). Carbon fiber reinforced vs titanium implants for fixation in spinal metastases: A comparative clinical study about safety and effectiveness of the new "carbon-strategy". Journal of clinical neuroscience, 75, 106-111. https://doi.org/10.1016/j.jocn.2020.03.013

Nurettin, D., & Burak, B. (2018). Feasibility of carbon-fiber-reinforced polymer fixation plates for treatment of atrophic mandibular fracture: A finite element method. Journal of cranio-maxillo-facial surgery, 46(12), 2182-2189. https://doi.org/10.1016/j.jcms.2018.09.030

Samiezadeh, S., Schemitsch, E. H., Zdero, R., & Bougherara, H. (2020). Biomechanical Response under Stress-Controlled Tension-Tension Fatigue of a Novel Carbon Fiber/Epoxy Intramedullary Nail for Femur Fractures. Medical engineering & physics, 80, 26-32. https://doi.org/10.1016/j.medengphy.2020.04.001

Elgali, I., Omar, O., Dahlin, C., & Thomsen, P. (2017). Guided bone regeneration: materials and biological mechanisms revisited. European journal of oral sciences, 125(5), 315-337. https://doi.org/10.1111/eos.12364

Baba, K., Mikhailov, A., & Sankai, Y. (2019). Long-term safety of the carbon fiber as an implant scaffold material. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2019, 1105-1110. https://doi.org/10.1109/EMBC.2019.8856629

Wang, L., Li, G., Ren, L., Kong, X., Wang, Y., Han, X., Jiang, W., Dai, K., Yang, K., & Hao, Y. (2017). Nano-copper-bearing stainless steel promotes fracture healing by accelerating the callus evolution process. International journal of nanomedicine, 12, 8443-8457. https://doi.org/10.2147/IJN.S146866

Dedukh, N. V., Karpinsky, M. J., Chzhou, L., & Malyshkina, S. V. (2016). Regeneratsiya i mekhanicheskaya prochnost kosti v usloviyakh implantatsii uglerodnogo materiala [Regeneration and mechanical strength of bone in the implantation conditions of carbon material]. Ortopediya, travmatologiya i protezirovanie, (3), 41-47. [in Russian]. https://doi.org/10.15674/0030-59872016341-47

Korzh, N. A., Dedukh, N. V., Tyazhelov, A. A., & Chzhou, L. (2017) Eksperimentalno-klinicheskoe issledovanie primenenyia uglerodnykh biomaterialov v ortopedyi i travmatologyi (obzor literatury) [Experimental clinical study of the use of carbon biomaterials in orthopedics and traumatology (literature review)]. Ortopediya, travmatologiya i protezirovanie, (2), 114-121. [in Russian]. https://doi.org/10.15674/0030-598720172114-121

Teuben, M. P. J., Hofman, M., Shehu, A., Greven, J., Qiao, Z., Jensen, K. O., Hildebrand, F., Pfeifer, R., & Pape, H. C. (2020). The impact of intramedullary nailing on the characteristics of the pulmonary neutrophil pool in rodents. International orthopaedics, 44(3), 595-602. https://doi.org/10.1007/s00264-019-04419-6

Shiels, S. M., Bouchard, M., Wang, H., & Wenke, J. C. (2018). Chlorhexidine-releasing implant coating on intramedullary nail reduces infection in a rat model. European cells & materials, 35, 178-194. https://doi.org/10.22203/eCM.v035a13

Danoff, J. R., Aurégan, J. C., Coyle, R. M., Burky, R. E., & Rosenwasser, M. P. (2016). Augmentation of Fracture Healing Using Soft Callus. Journal of orthopaedic trauma, 30(3), 113-118. https://doi.org/10.1097/BOT.0000000000000481

Barabás, R., de Souza Ávila, E., Ladeira, L., Antônio, L., Tötös, R., Simedru, D., Bizo, L., & Cadar, O. (2019). Graphene Oxides/Carbon Nanotubes–Hydroxyapatite Nanocomposites for Biomedical Applications. Arabian journal for science and engineering, 45(1), 219-227. https://doi.org/10.1007/s13369-019-04058-4

Wright, Z. M., Arnold, A. M., Holt, B. D., Eckhart, K. E., & Sydlik, S. A. (2019). Functional Graphenic Materials, Graphene Oxide, and Graphene as Scaffolds for Bone Regeneration. Regenerative Engineering and Translational Medicine, 5(2), 190-209. https://doi.org/10.1007/s40883-018-0081-z

Shin, Y. C., Song, S. J., Jeong, S. J., Kim, B., Kwon, I. K., Hong, S. W., Oh, J. W., & Han, D. W. (2018). Graphene-Based Nanocomposites as Promising Options for Hard Tissue Regeneration. Advances in experimental medicine and biology, 1078, 103-117. https://doi.org/10.1007/978-981-13-0950-2_6

Published

2023-11-03

How to Cite

1.
Golovakha ML, Chornyi VV. Results of a clinical trial of humeral neck osteosynthesis with carbon – carbon composite material. Current issues in pharmacy and medicine: science and practice [Internet]. 2023Nov.3 [cited 2024Dec.5];16(3):254-9. Available from: http://pharmed.zsmu.edu.ua/article/view/286567