The use of Thiocetam in the complex therapy of combat-related brain contusion

Authors

DOI:

https://doi.org/10.14739/2409-2932.2023.2.281460

Keywords:

nootropic agents, brain injuries, oxidative stress, neuroprotective agents, contusions, cognitive function

Abstract

Each patient presents a unique set of characteristics and challenges when it comes to acute cerebral ischemia resulting from craniocerebral injury.

The aim of this study is to investigate the utilization of Thiocetam as part of a comprehensive treatment approach for combat-related cerebral contusion and to assess the therapeutic effects of Thiocetam in patients with mild and moderate closed combat craniocerebral trauma in comparison to standard basic therapy.

Materials and methods. 79 patients with mild and moderate closed combat craniocerebral trauma were examined. Among them, 76 patients experienced craniocerebral trauma due to an explosive blast injury, which included conditions such as brain concussion, mild cerebral contusion, and cranial vault fractures. All patients were admitted to the department during the acute period of their injuries.

During the study, various clinical and functional methods were employed to assess the condition of the central nervous system. These methods were used to evaluate the effects of the complex treatment administered to the patients.

Results. The administration of Thiocetam to the patients did not result in an increase in excitability, nervousness, or sleep disturbances. Furthermore, the examination of autonomic reactivity following Thiocetam treatment revealed that the indicator of normal autonomic reactivity increased to 60 % in the treated group, whereas it only increased to 42 % in the control group. Additionally, the patients with initially heightened vegetative reactions experienced a decrease from 42.8 % to 17.9 % in the treated group, while the control group saw a decrease from 38.5 % to 23.1 %. In terms of clinical outcomes, a positive effect was observed in 94 % of patients in the Thiocetam-treated group within the first 5 days. In comparison, the control group showed a positive clinical effect in 76 % of cases. This improvement was evident both in the clinical field and based on indicators of autonomic reactivity in EEG data, as well as cognitive function assessed by the MMSE cognitive function test scale.

Conclusions. The utilization of Thiocetam during the acute phase of mild and moderate closed combat craniocerebral trauma enhances the neuroprotective effects of basic therapy. The combined drug Thiocetam, which possesses both nootropic and neuroprotective effects, offers the advantage of reducing or even avoiding the side effects commonly associated with traditional racetam nootropics.

Author Biographies

I. F. Bielenichev, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

PhD, DSc, Professor, Head of the Department of Pharmacology and Medical Formulation with Course of Normal Physiology

K. Yu. Nerianov, LLC SPA “Pharmatron”, Zaporizhzhia, Ukraine

MD, PhD, Associate Professor

V. I. Chernii, State Scientific Institution “Scientific and Practical Center of Preventive and Clinical Medicine” of the State Administration of Affairs, Kyiv

Professor, Corresponding member of the National Academy of Medical Sciences of Ukraine

D. A. Sereda, LLC SPA “Pharmatron”, Zaporizhzhia, Ukraine

Neurosurgeon of the Highest Category

L. I. Kucherenko, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

PhD, DSc, Professor, Head of the Department of Pharmaceutical, Organic and Bioorganic Chemistry

N. V. Derevianko, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

PhD, Senior Lecturer of the Department of Pharmaceutical, Organic and Bioorganic Chemistry

К. І. Kandybei, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine

PhD, Associate Professor of the Department of Pharmaceutical, Organic and Bioorganic Chemistry

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Published

2023-07-03

How to Cite

1.
Bielenichev IF, Nerianov KY, Chernii VI, Sereda DA, Kucherenko LI, Derevianko NV, Kandybei КІ. The use of Thiocetam in the complex therapy of combat-related brain contusion. Current issues in pharmacy and medicine: science and practice [Internet]. 2023Jul.3 [cited 2024Feb.26];16(2):170-4. Available from: http://pharmed.zsmu.edu.ua/article/view/281460

Issue

Section

Original research