Сirculating osteonectin as a prognostic biological marker in patients with ischemic chronic heart failure
Keywords:Osteonectin, Chronic Disease, Heart Failure, Prognosis, Survival, Hospitalization
Aim: To evaluate the prognostic value of circulating osteonectin for cumulative survival in patients with ischemic chronic heart failure (CHF).
Methods: A total of 154 patients with ischemic symptomatic moderate-to-severe CHF were enrolled in the study. Observation period was up to 3 years. ELISA methods for measurements of circulating level of osteonectin were used. Concentrations of osteonectin for cumulative survival cases due to advanced CHF were tested. Additionally, all-cause mortality, and CHF-related death were examined.
Conclusion: Increased circulating osteonectin associates with increased 3-year CHF-related death, and risk for hospitalization due to CHF.
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