The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives


  • I. M. Bilay
  • E. O. Mihayluk
  • V. V. Parchenko
  • A. G. Kaplaushenko
  • A. I. Panasenko
  • E. G. Knysh



Pharmacological Actions, Drug Screening, Animal Experimental, Toxic Hepatitis, 1, 2, 4-triazole


Aim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats.

Methods and results. Compounds have been entered in a 1/10 dose of LD50, which have been determined before performing experiments. The article presents hepatoprotective activity of new synthesized compounds in simulated acute liver injury. We present a comparison with reference drugs in the experiment.

Сonclusion. Screening has shown that these class of compounds is promising for further research.


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How to Cite

Bilay IM, Mihayluk EO, Parchenko VV, Kaplaushenko AG, Panasenko AI, Knysh EG. The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives. CIPM [Internet]. 2014Jul.8 [cited 2023Dec.8];(2). Available from:



Experimental and clinical pharmacology