The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives

Authors

  • I. M. Bilay
  • E. O. Mihayluk
  • V. V. Parchenko
  • A. G. Kaplaushenko
  • A. I. Panasenko
  • E. G. Knysh

DOI:

https://doi.org/10.14739/2409-2932.2014.2.26165

Keywords:

Pharmacological Actions, Drug Screening, Animal Experimental, Toxic Hepatitis, 1, 2, 4-triazole

Abstract

Aim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats.

Methods and results. Compounds have been entered in a 1/10 dose of LD50, which have been determined before performing experiments. The article presents hepatoprotective activity of new synthesized compounds in simulated acute liver injury. We present a comparison with reference drugs in the experiment.

Сonclusion. Screening has shown that these class of compounds is promising for further research.

References

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Morozov, S. Yu. (2009) Gepatoprotektory v praktike vracha-klinicista [Hepatoprotectors in practic work of clinic doctor]. Russkij medicinskij zhurnal, 11(1), 25. [in Russian].

Polunina, T. E., Maev, I. V., & Polunina, E. V. (2009) Hepatologiya dlya practicheskogo vracha [Hepatology for practic doctor]. Moscow: Avtorskaya academiya. [in Russian].

Prozorovskii, V. B. (2007) Statisticheskaya obrabotka rezul'tatov farmakologicheskikh issledovanij [Statistic processing of data of pharmacological investigations]. Psikhofarmakologiya i biologicheskaya narkologiya, 7(3-4), 2090–2120. [in Russian].

Tkach, S. M. (2009) [Effectiveness and safety hepatoprotectors terms of evidence-based medicine]. Zdorov`e Ukrainy, 6, 7–10. [inUkrainian].

Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., et al. (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with non–alcoholic fatty liver disease. J Clin Invest, 115(5), 1343–1351.

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How to Cite

1.
Bilay IM, Mihayluk EO, Parchenko VV, Kaplaushenko AG, Panasenko AI, Knysh EG. The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives. Current issues in pharmacy and medicine: science and practice [Internet]. 2014Jul.8 [cited 2024Apr.18];(2). Available from: http://pharmed.zsmu.edu.ua/article/view/26165

Issue

No. 2 (2014)

Section

Experimental and clinical pharmacology

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