Quantitative determination of zopiclone tablets «Sonovan» by spectrophotometry

Authors

  • S. L. Zagorodniy
  • S. O. Vasyuk

DOI:

https://doi.org/10.14739/2409-2932.2014.2.26128

Keywords:

Spectrophotometry, Zopiclone, Bromothymol blue, Quantification

Abstract

Aim. A new spectrophotometric method of assay zopiclone based on its interaction with bromtymol blue in acetone solution and measuring the absorption of the reaction product in the visible spectrum at a wavelength of 400 nm.

Methods and results. The method used to quantify dimedrol in dosage forms - tablets «Sonovan». The basic characteristics validated by the State Pharmacopoeia of Ukraine.

Conclusion. According to the obtained experimental data, the technique can be correctly reproduced and is suitable for use in pharmaceutical and forensic analytical laboratories.

References

Mashkovskij, M. D. (2012) Lekarstvennie sredstva [The medicaments]. Moscow : Novaia volna. [in Russian].

Hsua, R., Chanb, S., Lina, S., Lina, T., Chuc, W., Fuh, M. (2013). Direct quantitative analysis of benzodiazepines, metabolites, and analogs in diluted human urine by rapid resolution liquid chromatography–tandem mass spectrometry. Journal of Food and Drug Analysis, 21(4), 376–383. doi: 10.1016/j.jfda.2013.08.005. ISSN: 1021-9498.

Nielsen, M. K. K., Johansen, S. S., Linnet, K. (2014). Pre-analytical and analytical variation of drug determination in segmented hair using ultra-performance liquid chromatography–tandem mass spectrometry. Forensic Science International, 234, 16–21. doi: 10.1016/j.forsciint.2013.10.029.

Ishida, T., Kudo, K., Hayashida, M., Ikeda, N. (2009). Rapid and quantitative screening method for 43 benzodiazepines and their metabolites, zolpidem and zopiclone in human plasma by liquid chromatography/mass spectrometry with a small particle column. J. of Chromatography B. 877(25), 2652–2657. doi: 10.1016/j.jchromb.2009.05.008.

Salomone, A., Gerace, E., Brizio, P., Gennaro, M. C., Vincenti, M. (2011). A fast liquid chromatography–tandem mass spectrometry method for determining benzodiazepines and analogues in urine. Validation and application to real cases of forensic interest. Journal of Pharmaceutical and Biomedical Analysis, 56(3), 582–591. doi: 10.1016/j.jpba.2011.06.007. doi: 10.1016/j.forsciint.2010.02.012.

Adamowicz, P., Kała, M. (2010). Simultaneous screening for and determination of 128 date-rape drugs in urine by gas chromatography-electron ionization-mass spectrometry. Forensic Science International, 198(1–3), 39–45. doi: 10.1016/j.forsciint.2010.02.012

Nilsson, G. H., Kugelberg, F. C., Kronstrand, R., Ahlner, J. (2010). Stability tests of zopiclone in whole blood. Forensic Science International, 200(1–3), 130–135. doi: 10.1016/j.forsciint.2010.04.001.

Papoutsis, I. I., Athanaselis, S. A., Nikolaou, P. D., Pistos, C. M., Spiliopoulou, C. A., Maravelias, C. P. (2010). Development and validation of an EI–GC–MS method for the determination of benzodiazepine drugs and their metabolites in blood: Applications in clinical and forensic toxicology. J. of Chromatography B: Biomedical Sciences and Applications, 52(4), 609–614. doi: 10.1016/j.jpba.2010.01.027.

Viré, J. C., Zhang, H., Quarin, G. (1993). Electrochemical behavior of zopiclone. Talanta, 40(3), 313–323.

Szökő, É., Tábi, T. (2010). Analysis of biological samples by capillary electrophoresis with laser induced fluorescence detection. J. of Chromatography B: Biomedical Sciences and Applications, 53(5), 1180–1192. doi: 10.1016/j.jpba.2010.07.045.

(2008). Derzhavna Farmakopeia Ukrainy [State Pharmacopoeia of Ukraine] Kharkov: Naukovo-ekspertnii farmakopeinii centr. [in Ukrainian].

Downloads

How to Cite

1.
Zagorodniy SL, Vasyuk SO. Quantitative determination of zopiclone tablets «Sonovan» by spectrophotometry. Current issues in pharmacy and medicine: science and practice [Internet]. 2014Jul.8 [cited 2024Jul.16];(2). Available from: http://pharmed.zsmu.edu.ua/article/view/26128

Issue

No. 2 (2014)

Section

Analysis and standardization of biologycally active substances and dosage forms

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.     Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)