Quantitative determination of zopiclone tablets «Sonovan» by spectrophotometry

Authors

  • S. L. Zagorodniy
  • S. O. Vasyuk

DOI:

https://doi.org/10.14739/2409-2932.2014.2.26128

Keywords:

Spectrophotometry, Zopiclone, Bromothymol blue, Quantification

Abstract

Aim. A new spectrophotometric method of assay zopiclone based on its interaction with bromtymol blue in acetone solution and measuring the absorption of the reaction product in the visible spectrum at a wavelength of 400 nm.

Methods and results. The method used to quantify dimedrol in dosage forms - tablets «Sonovan». The basic characteristics validated by the State Pharmacopoeia of Ukraine.

Conclusion. According to the obtained experimental data, the technique can be correctly reproduced and is suitable for use in pharmaceutical and forensic analytical laboratories.

References

Mashkovskij, M. D. (2012) Lekarstvennie sredstva [The medicaments]. Moscow : Novaia volna. [in Russian].

Hsua, R., Chanb, S., Lina, S., Lina, T., Chuc, W., Fuh, M. (2013). Direct quantitative analysis of benzodiazepines, metabolites, and analogs in diluted human urine by rapid resolution liquid chromatography–tandem mass spectrometry. Journal of Food and Drug Analysis, 21(4), 376–383. doi: 10.1016/j.jfda.2013.08.005. ISSN: 1021-9498.

Nielsen, M. K. K., Johansen, S. S., Linnet, K. (2014). Pre-analytical and analytical variation of drug determination in segmented hair using ultra-performance liquid chromatography–tandem mass spectrometry. Forensic Science International, 234, 16–21. doi: 10.1016/j.forsciint.2013.10.029.

Ishida, T., Kudo, K., Hayashida, M., Ikeda, N. (2009). Rapid and quantitative screening method for 43 benzodiazepines and their metabolites, zolpidem and zopiclone in human plasma by liquid chromatography/mass spectrometry with a small particle column. J. of Chromatography B. 877(25), 2652–2657. doi: 10.1016/j.jchromb.2009.05.008.

Salomone, A., Gerace, E., Brizio, P., Gennaro, M. C., Vincenti, M. (2011). A fast liquid chromatography–tandem mass spectrometry method for determining benzodiazepines and analogues in urine. Validation and application to real cases of forensic interest. Journal of Pharmaceutical and Biomedical Analysis, 56(3), 582–591. doi: 10.1016/j.jpba.2011.06.007. doi: 10.1016/j.forsciint.2010.02.012.

Adamowicz, P., Kała, M. (2010). Simultaneous screening for and determination of 128 date-rape drugs in urine by gas chromatography-electron ionization-mass spectrometry. Forensic Science International, 198(1–3), 39–45. doi: 10.1016/j.forsciint.2010.02.012

Nilsson, G. H., Kugelberg, F. C., Kronstrand, R., Ahlner, J. (2010). Stability tests of zopiclone in whole blood. Forensic Science International, 200(1–3), 130–135. doi: 10.1016/j.forsciint.2010.04.001.

Papoutsis, I. I., Athanaselis, S. A., Nikolaou, P. D., Pistos, C. M., Spiliopoulou, C. A., Maravelias, C. P. (2010). Development and validation of an EI–GC–MS method for the determination of benzodiazepine drugs and their metabolites in blood: Applications in clinical and forensic toxicology. J. of Chromatography B: Biomedical Sciences and Applications, 52(4), 609–614. doi: 10.1016/j.jpba.2010.01.027.

Viré, J. C., Zhang, H., Quarin, G. (1993). Electrochemical behavior of zopiclone. Talanta, 40(3), 313–323.

Szökő, É., Tábi, T. (2010). Analysis of biological samples by capillary electrophoresis with laser induced fluorescence detection. J. of Chromatography B: Biomedical Sciences and Applications, 53(5), 1180–1192. doi: 10.1016/j.jpba.2010.07.045.

(2008). Derzhavna Farmakopeia Ukrainy [State Pharmacopoeia of Ukraine] Kharkov: Naukovo-ekspertnii farmakopeinii centr. [in Ukrainian].

How to Cite

1.
Zagorodniy SL, Vasyuk SO. Quantitative determination of zopiclone tablets «Sonovan» by spectrophotometry. Current issues in pharmacy and medicine: science and practice [Internet]. 2014Jul.8 [cited 2024Dec.24];(2). Available from: http://pharmed.zsmu.edu.ua/article/view/26128

Issue

Section

Analysis and standardization of biologycally active substances and dosage forms