Natural aspirin of some members of the Rosaceae and Salicaceae families

Authors

DOI:

https://doi.org/10.14739/2409-2932.2022.2.256639

Keywords:

Filipendula vulgaris Moench., , Salix alba L., tincture, mass spectrometry, HPLC (high pressure liquid chromatography)

Abstract

White willow Salix alba L., a member of the family Salicaceae is characterized by the presence of phenolic compounds and their glycosides (1.5–11.0 %), such as salicin, salicortin, salireposide, picein, triandrin, syringin, tremulacin, flavonoids (1–4 %) namely luteolin, apigenin, quercetin, quercimeritrin, cosmosin, diosmetin, tannins (8–20 %) i.e. catechins, anthocyanidins, halotanines of organic acids, ascorbic acid. Preparations of white willow bark are used as an antipyretic, anti-inflammatory, diaphoretic, analgesic, diuretic, and astringent. The rhizomes with roots of the commonly known dropwort or fern-leaf dropwort are Filipendula vulgaris Moench., member of the family Rosaceae are characterized by phenologicoside gaulterin, the hydrolysis of which produces salicylic aldehyde, tannins (up to 33 %), flavonoids, ascorbic acid, polysaccharides, starch. The herbs and flowers are used as anti-inflammatory, anti-rheumatic, vasodilator, gastric, and antiulcer agents.

The aim of the work is to determine the composition of the white willow bark Salix alba L. tincture, a member of the willow family Salicaceae, using gas-liquid chromatography (GLC) and HPLC and to determine the composition of the tincture of the dropwort root Filipendula vulgaris Moench. family Rosaceae.

Materials and methods. Raw materials (underground organs) of the dropwort Filipendula vulgaris Moench. and bark of the white willow Salix alba L., which were harvested in July 2020 at the ZSMU research site. Tinctures were prepared according to the production recipe (1:5) (extractant was 70 % ethanol), investigated by the gas chromatograph Agilent 7890B with mass spectrometric detector 5977B. The mass spectra library NIST 14 was used to identify the components. White willow bark tincture (70 % ethyl alcohol extractant) was used to determine the phenolic compounds content and salicylic acid derivatives. The study was performed by HPLC (high-performance liquid chromatography) and HPLC MS.

Results. Qualitative and quantitative analysis of the components of Salix alba L. willow bark tincture was performed by gas-liquid chromatography, 39 components of different classes of biologically active compounds have been identified, among which the 10 components are predominated in quantitative content. The main one was Salicin (39.53 %). The GC analysis of the tincture of the dropwort roots, Filipendula vulgaris Moench., identified 34 components of different groups of biologically active compounds, dominated by 11 components, the main is Ethyl.alpha.-d-glucopyranoside (34.55 %). HPLC analysis confirmed the presence of phenolic compounds (flavonoids such as apigenin, and quercetin) and salicylic acid derivatives (glycoside salicin) in the tincture of white willow bark (Salix alba L.).

Conclusions. By GC analysis the 39 components in tincture of white willow bark Salix alba L. were identified, 10 components were predominated, the main one was Salicin (39.53 %). The 34 components in the tincture of the dropwort roots, Filipendula vulgaris Moench., were identified, dominated by 11 components, the main was Ethyl.alpha.-d-glucopyranoside (34.55 %). The presence of phenolic compounds (flavonoids were apigenin and quercetin) and salicylic acid derivatives (glycoside salicin) was confirmed by HPLC MS in the tincture of white willow bark (Salix alba L.).

Author Biographies

Yu. I. Korniievskyi, Zaporizhzhia State Medical University, Ukraine

PhD, Associate Professor of the Department of Pharmacognosy, Pharmacology and Botany

O. I. Panasenko, Zaporizhzhia State Medical University, Ukraine

PhD, DSc, Professor, Head of the Department of Natural Sciences for Foreign Students and Toxicological Chemistry

V. H. Korniievska, Zaporizhzhia State Medical University, Ukraine

PhD, Associate Professor of the Department of Pharmacognosy, Pharmacology and Botany

B. O. Varynskyi, Zaporizhzhia State Medical University, Ukraine

PhD, DSc, Associate Professor of the Department of Physical and Colloidal Chemistry

M. M. Maletskyi, Zaporizhzhia State Medical University, Ukraine

PhD, Senior Lecturer of the Department of Medicines Technology

References

Korniievska, V. H., Khmura, T. A., Karpun, Ye. O., & Korniievskyi, Yu. I. (2020, November 26-27). Khromato-mas-spektrometrychna kharakterystyka syrovyny verby biloi [Chromato-mass spectrometric characteristics of raw willow]. Teoretychni ta praktychni aspekty doslidzhennia likarskykh Roslyn. Proceedings of the 4th International Scientific-Practical Internet Conference (pp. 132-133). Kharkiv : NFaU. [in Ukrainian].

Korniievska, V. H., Khmura, T. A., & Korniievskyi, Yu. I. (2022, February 18). Porivnialna kharakterystyka nastoiok koreniv hadiuchnyka zvychainoho ta kory verby biloi [Comparative characteristics of tinctures of viper roots and white willow bark]. PLANTA+. SCIENCE, PRACTICE AND EDUCATION. Proceedings of the 3rd Scientific and Practical Conference with International Participation, dedicated to the 180th anniversary of Bogomolets National Medical University (Vol. 2, pp. 56-59). Kyiv. [in Ukrainian].

Korniievskyi, Yu. I., Kucherenko, L. I., Korniievska, V. H., Skoryna, D. Yu., Khromylova, O. V., & Bohuslavska, N. Yu. (2020). Likarski roslyny na aptechnii polytsi [Medicinal plants on the pharmacy shelf]. Zaporizhzhia: ZSMU. [in Ukrainian].

Kryvenko, V. I., Korniievskyi, Yu. I., Kolesnyk, M. Yu., Korniievska V. H., Bohuslavska N. Yu., Pakhomova S. P., Skoryna D. Yu., & Fedorova O. P. (2021). Fitoterapiia v hastroenterolohii [Phytotherapy in gastroenterology]. Kyiv : Vydavnychyi dim "Medknyha". [in Ukrainian].

Fandakli, S., Korkmaz, B., Faiz, Ö., Kiliç, G., Erik, İ., Terzioğlu, S., & Yaylı, N. (2021). Chemical Variation, Antimicrobial, Nitric Oxide Scavenging Activities and Tyrosinase Inhibition of Essential Oils and Solvent Extracts from Filipendula vulgaris Moench Growing in Turkey. Iranian journal of pharmaceutical research : IJPR, 20(3), 110-120. https://doi.org/10.22037/ijpr.2021.114302.14786

Feng, S. I., Su, C., Duan, S. Y., & Chen, L. R. (2001). Chemical constituents from Salix oritrepha Schneid. China journal of Chinese materia medica, 26(9), 607-608.

Gomes, J., Herz, C., Helmig, S., Förster, N., Mewis, I., & Lamy, E. (2021). Drug-Drug Interaction Potential, Cytotoxicity, and Reactive Oxygen Species Production of Salix Cortex Extracts Using Human Hepatocyte-Like HepaRG Cells. Frontiers in pharmacology, 12, 779801. https://doi.org/10.3389/fphar.2021.779801

Gainche, M., Ogeron, C., Ripoche, I., Senejoux, F., Cholet, J., Decombat, C., Delort, L., Berthon, J. Y., Saunier, E., Caldefie Chezet, F., & Chalard, P. (2021). Xanthine Oxidase Inhibitors from Filipendula ulmaria (L.) Maxim. and Their Efficient Detections by HPTLC and HPLC Analyses. Molecules (Basel, Switzerland), 26(7), 1939. https://doi.org/10.3390/molecules26071939

Published

2022-08-01

How to Cite

1.
Korniievskyi YI, Panasenko OI, Korniievska VH, Varynskyi BO, Maletskyi MM. Natural aspirin of some members of the Rosaceae and Salicaceae families. Current issues in pharmacy and medicine: science and practice [Internet]. 2022Aug.1 [cited 2024Jun.16];15(2):153-9. Available from: http://pharmed.zsmu.edu.ua/article/view/256639

Issue

Section

Original research