Search for potential hypoglycemic agents among potassium salts of 3-benzyl-8-substituted xanthines

Authors

DOI:

https://doi.org/10.14739/2409-2932.2022.3.253385

Keywords:

xanthines, organic synthesis, hypoglycemic activity

Abstract

Nowadays, the prevalence of metabolic syndrome (MS) is a serious problem among the world’s population. Metabolic syndrome includes the so-called “deadly” quartet – hypertension, type 2 diabetes mellitus (diabetes mellitus), dyslipidemia and alimentary obesity.

After all, type 2 diabetes is included in the list of pathologies of the metabolic syndrome, it is important to find ways to alleviate the disease. Derivatives of such a heterocyclic system as xanthine are of great interest in this aspect.

The aim of the study was to explore the hypoglycemic activity of newly synthesized water-soluble derivatives of 3-benzyl-8-substituted xanthines.

Materials and methods. We obtained water-soluble potassium 3-benzyl-8-R-xanthin-7-ides, the structure and individuality of which were confirmed by a set of physical-chemical studies.

Results. The hypoglycemic effect of the newly synthesized compounds was assessed by an oral glucose tolerance test. The obtained data were processed using modern statistical in silico-methods.

Conclusions. The results of the hypoglycemic activity study among the potassium salts of 3-benzyl-8-substituted xanthine derivatives showed, that some new compounds are in close vicinity to the reference drug’s hypoglycemic action.

 

Author Biographies

K. V. Aleksandrova, Zaporizhzhia State Medical University, Ukraine

PhD, DSc, Professor, Head of the Department of Biological Chemistry

Ye. S. Pruhlo, Zaporizhzhia State Medical University, Ukraine

PhD, DSc, Associate Professor of the Department of Clinical Pharmacy, Pharmacognosy and Pharmaceutical Chemistry, Head of the Department of Experimental Research with a Vivarium

Ye. K. Mykhalchenko, Zaporizhzhia State Medical University, Ukraine

PhD, Assistant of the Department of Biological Chemistry

O. S. Shkoda, Zaporizhzhia State Medical University, Ukraine

PhD, Associate Professor of the Department of Biological Chemistry

O. Yu. Cherchesova, Zaporizhzhia State Medical University, Ukraine

PhD, Assistant of the Department of Biological Chemistry

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Published

2022-11-15

How to Cite

1.
Aleksandrova KV, Pruhlo YS, Mykhalchenko YK, Shkoda OS, Cherchesova OY. Search for potential hypoglycemic agents among potassium salts of 3-benzyl-8-substituted xanthines. Current issues in pharmacy and medicine: science and practice [Internet]. 2022Nov.15 [cited 2024May24];15(3):266-70. Available from: http://pharmed.zsmu.edu.ua/article/view/253385

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Original research