Development of industrial technology of plant substance of cultivated parsnip herb thick extract

Authors

DOI:

https://doi.org/10.14739/2409-2932.2022.1.251976

Keywords:

pastinaca, plant extract, technology

Abstract

The aim of the work is to develop the industrial technology of domestic phyto-substance of cultivated parsnip herb thick extract (CPHTE) with the aim of its further introduction into a tablet dosage form of cardioprotective action.

Materials and methods. As an object of research, the experimental samples of parsnip herb (Pastinacae sativae herba) of the domestic selection of the Petryk variety, harvested on the experimental fields of the Institute of Vegetable and Melon Growing of the National Academy of Agrarian Sciences of Ukraine (Kharkiv region) were used to obtain the plant substance CPHTE (Pastinacae sativae herbae extractispissi).

Results. The results of experimental research were used while development of a block scheme of the production technological process of plant substance CPHTE and an apparatus scheme tested in industrial conditions of LLC Pharmaceutical Company “Zdorovye” (Kharkiv, Ukraine) and control technological parameters for each stage of the technological process for manufacturing the developed thick extract have been established.

Conclusions. The technology of the domestic plant substance CPHTE production, as well as the blocking scheme of the technological process, and the apparatus scheme tested in industrial conditions of LLC Pharmaceutical Company “Zdorovye” (Kharkiv) had been theoretically substantiated and experimentally developed. The results of the experiment were used in the development of methods for quality control projects and technological regulations for the developed plant substance.

Author Biographies

N. A. Symonenko, National University of Pharmacy, Kharkiv, Ukraine

PhD-student of the Department of Industrial Pharmacy and Economy, Institute for Advanced Training of Pharmacy Specialists

O. S. Shpychak, National University of Pharmacy, Kharkiv, Ukraine

Dr.hab., Professor, Head of the Department of Industrial Pharmacy and Economy, Institute for Advanced Training of Pharmacy Specialists

References

Symonenko, N., & Shpychak, О. (2021). Zahalna kontseptsiia ta metodolohiia stvorennia tverdykh likarskykh zasobiv z roslynnymy ekstraktamy dlia likuvannia sertsevo-sudynnykh zakhvoriuvan [General concept and methodology of developing solid medicines plant extracts for the treatment of cardiovascular vessels]. SSP Modern Pharmacy and Medicine, 1(2), 1-17. [in Ukrainian]. https://doi.org/10.53933/sspmpm.v1i2.33

Korniievskyi, Yu. I., Kraidashenko, O. B., Krasko, M. P., Bohuslavska, N. Yu., Korniievska, V. H., & Opryshko, B. I. (2017). Fitoterapiia v kardiolohii [Phytotherapy in cardiology]. Zaporizhzhia: ZSMU. [in Ukrainain].

Altemimi, A., Lakhssassi, N., Baharlouei, A., Watson, D. G., & Lightfoot, D. A. (2017). Phytochemicals: Extraction, Isolation, and Identification of Bioactive Compounds from Plant Extracts. Plants, 6(4), 42. https://doi.org/10.3390/plants6040042

Harna, S. V., Vladymyrova, I. M., Burd, N. B., Heorhiiants, V. A., Kotov, A. H., Prokopenko, T. S., Vasylieva, O. A., Hlushchenko, A. V., Drozdova, O. O., Kolesnikov, O. V., Prokopenko, Yu. S., Savchenko, L. P., Mishchenko, V. A., & Bondarieva, L. V. (2016). Suchasna fitoterapiia [Modern phytotherapy]. Kharkiv: Drukarnia Madryd. [in Ukrainain].

Popova, N. V., & Litvenenko, V. I. (2016). Lekarstvennye rasteniya mirovoi flory [Medicinal plants of the world flora]. Kharkov: Disa-plyus. [in Rissian].

Symonenko, N. A., & Shpychak, O. S. (2018, February 22-23). Pasternak posivnyi – perspektyvna syrovyna dlia zastosuvannia v medytsyni, farmatsii ta kosmetolohii [Pasternak sowing is a promising raw material for use in medicine, pharmacy and cosmetology]. Kosmetolohiia ta aromolohiia: etapy stanovlennia i maibutnie. Proceedings of the International scientific-practical conference (pp. 127-130). Kharkiv: National University of Pharmacy. [in Ukrainain].

Symonenko, N. A., & Shpychak, O. S. (2018). Vydy, khimichnyi sklad ta farmakolohichna diia rodu roslyn Pastinaca, shcho zastosovuiutsia v medytsyni i farmatsii [Species, chemical composition and pharmacological action of the genus Pastinaca used in medicine and pharmacy]. Suchasni dosiahnennia farmatsevtychnoi tekhnolohii i biotekhnolohii, (4), 230-235. Kharkiv: National University of Pharmacy. [in Ukrainain].

Horiacha, L., Symonenko, N., Galuzinska, L., Shpychak, O., & Kyslychenko, V. (2020). Doslidzhennia kardioprotektornoi dii pasternaku posivnoho travy ekstraktu hustoho [The study of the cardioprotective action of the thick extract of parsnip herb]. Ukrainskyi biofarmatsevtychnyi zhurnal – Ukrainian biopharmaceutical journal, (4), 46-50. [in Ukrainain]. https://doi.org/10.24959/ubphj.20.294

Shimorova, J. E., Kyslychenko, V. S., & Kuznietsova, V. Yu. (2017). Vyvchennia zhyrnokyslotnoho skladu koreneplodiv Pastinaca sativa L. [Studing of fatty acids of Pastinaca sativa]. Fitoterapiia. Chasopys, (1), 46-49. [in Ukrainain].

Kuznietsova, V. Yu., Shimorova, Y. E., Boyko, N. N., Pisarev, D. I., Zhilyakova, E. T., & Novikov, O. O. (2017). HPLC analysis of hydro-ethanolic extracts from Pastinaca sativa L. fruits. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 8(6), 705-712.

Jovanović, S. Č., Jovanović, O. P., Petrović, G. M., & Stojanović, G. S. (2015). Endemic Balkan parsnip Pastinaca hirsuta: the chemical profile of essential oils, headspace volatiles and extracts. Natural product communications, 10(4), 661-664.

Tecucianu, A. C., & Oancea, S. (2019). Ultrasound-assisted and enzyme-assisted extraction of fructans and phenolics from parsnip (Pastinaca Sativa L.). Current Trends in Natural Sciences, 8(15), 29-34.

Beroxan. [in Russian]. https://www.webapteka.ru/drugbase/name944.html

Pastinacin. [in Russian]. https://www.webapteka.ru/drugbase/name9885.html

Shymorova, Yu. Ye., & Kyslychenko, V. S. (2020). Protyzapalnyi zasib na osnovi pasternaku posivnoho [Anti-inflammatory agent based on parsnip]. Ukraine Patent UA 139957. [in Ukrainain].

Symonenko, N. A., Mishchenko, O. Ya., Shpychak, O. S., Grashchenkova, S. A., Berezniakov, A. V., & Khalieieva, O. L. (2021). Cardioprotective properties of tablets with a thick extract of the herb Pasternak in the conditions of adrenaline myocardiodystrophy. Pharmacologyonline, 3, 376-382.

Ministry of Health of Ukraine. (2020). Guidelines ST-N MOH 42 4.0: 2020 "Medicines. Good manufacturing practice". https://www.dls.gov.ua/wp-content/uploads/2020/05/%D0%9D%D0%B0%D1%81%D1%82%D0%B0%D0%BD%D0%BE%D0%B2%D0%B0-%D0%A1%D0%A2-%D0%9D-%D0%9C%D0%9E%D0%97%D0%A3-42-4.0_2020.pdf

Published

2022-02-15

How to Cite

1.
Symonenko NA, Shpychak OS. Development of industrial technology of plant substance of cultivated parsnip herb thick extract. Current issues in pharmacy and medicine: science and practice [Internet]. 2022Feb.15 [cited 2024Jul.21];15(1):52-8. Available from: http://pharmed.zsmu.edu.ua/article/view/251976

Issue

Section

Original research