Research of the chemical composition of Artemisia tschernieviana Bess. by gas chromatography method with mass detection

Authors

  • O. I. Panasenko Zaporizhzhia State Medical University, Ukraine, Ukraine https://orcid.org/0000-0002-6102-3455
  • V. I. Mozul Zaporizhzhia State Medical University, Ukraine, Ukraine
  • O. M. Denysenko Zaporizhzhia State Medical University, Ukraine, Ukraine
  • I. I. Aksonova Zaporizhzhia State Medical University, Ukraine, Ukraine https://orcid.org/0000-0002-3534-700X
  • V. V. Holovkin Zaporizhzhia State Medical University, Ukraine, Ukraine

DOI:

https://doi.org/10.14739/2409-2932.2021.3.242650

Keywords:

Artemisia tschernieviana, GS-MS, component composition, quantitative content, anti-inflammatory effect, antidiabetic effect, antibacterial effect

Abstract

The aim of the work was to study chromato-mass spectroscopic of Artemisia tschernieviana Bess. grass and to establish possible prospects for the use of this plant in medical practice.

Materials and methods. Artemisia tschernieviana Bess. grass was chosen as the object of research. Raw materials were collected in July 2021 in the flowering phase (Zaporizhzhia). The tincture was obtained by maceration and the raw material was extracted with methyl alcohol at room temperature for 10 days according to the method of making tinctures. The study of the chemical composition of Artemisia tschernieviana Bess. Grass was carried out using gas chromatograph Agilent 7890B GC System (Agilent, Santa Clara, CA, USA) with mass spectrometric detector Agilent 5977 BGC/MSD (Agilent, Santa Clara, CA, USA) and chromatographic column DB-5ms (30 m × 250 μm × 0.25 μm).

Results. During the study it was found that the composition of Artemisia tschernieviana Bess. grass includes 21 compounds (2 in the isomeric state). β-myrcene (17.22 %), sabinene (14.54 %), 2-(4a,8-dimethyl-7-oxo-1,2,3,4,4a,7-hexahydronaphthalen-2-yl) propionic acid (11.57 %), 2-dodecen-1-yl-succinic anhydride (10.84 %) and chamazulene (9.02 %) accounted for the largest percentage.

According to the literature review, myrcene has antibacterial, anesthetic and analgesic effects. Sabinene is characterized by antibacterial action. 2-(4a,8-dimethyl-7-oxo-1,2,3,4,4a,7-hexahydronaphthalen-2-yl)-propionic acid is a fatty acid with possible antibacterial and anti-inflammatory activity. 2-dodecen-1-yl-succinic anhydride is used to produce anhydride-modified form of insulin that can be used in the treatment of diabetes. Hamazulen has anti-inflammatory activity.

Conclusions. In view of all the above, we can conclude that Artemisia tschernieviana Bess. grass can be recommended for further research as a source of potential anti-inflammatory and antibacterial agents.

Author Biographies

O. I. Panasenko, Zaporizhzhia State Medical University, Ukraine

PhD, DSc, Professor, Head of the Department of Natural Sciences for Foreign Students and Toxicological Chemistry

V. I. Mozul, Zaporizhzhia State Medical University, Ukraine

PhD, Associate Professor of the Department of Pharmacognosy, Pharmacology and Botany

O. M. Denysenko, Zaporizhzhia State Medical University, Ukraine

PhD, Associate Professor of the Department of Pharmacognosy, Pharmacology and Botany

I. I. Aksonova, Zaporizhzhia State Medical University, Ukraine

PhD, Teaching Assistant of the Department of Pharmacognosy, Pharmacology and Botany

V. V. Holovkin, Zaporizhzhia State Medical University, Ukraine

PhD, Associate Professor of the Department of Pharmacognosy, Pharmacology and Botany

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Published

2021-10-25

How to Cite

1.
Panasenko OI, Mozul VI, Denysenko OM, Aksonova II, Holovkin VV. Research of the chemical composition of Artemisia tschernieviana Bess. by gas chromatography method with mass detection. Current issues in pharmacy and medicine: science and practice [Internet]. 2021Oct.25 [cited 2024Nov.22];14(3):282-6. Available from: http://pharmed.zsmu.edu.ua/article/view/242650

Issue

Vol. 14 No. 3 (2021)

Section

Original research

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