Characteristic of the chemical composition of Artemisia pontica L.

Authors

  • O. I. Panasenko Zaporizhzhia State Medical University, Ukraine, Ukraine https://orcid.org/0000-0002-6102-3455
  • V. I. Mozul Zaporizhzhia State Medical University, Ukraine, Ukraine
  • O. M. Denysenko Zaporizhzhia State Medical University, Ukraine, Ukraine
  • I. I. Aksonova Zaporizhzhia State Medical University, Ukraine, Ukraine
  • T. V. Oberemko LLC “PMD-UKRAINE”, Kyiv, Ukraine

DOI:

https://doi.org/10.14739/2409-2932.2021.1.226743

Keywords:

Artemisia pontica, chromato-mass spectroscopy, component composition, quantitative content

Abstract

The aim of this work is to determine the qualitative and quantitative characteristics of biologically active compounds of Artemisia pontica L. Definition prospects of medicinal herbal raw materials in the treatment of diseases.

Materials and methods. Research material (Artemisia pontica L. herb) was collected in August 2019 in the Zaporizhzhia region, Ukraine. The tincture was obtained by maceration. So, the tincture was being extracted with methyl alcohol at room temperature for 10 days. The tincture was extracted with methyl alcohol at room temperature for 10 days according to the method of preparing tinctures. The study of the chemical composition of tincture of Artemisia pontica L. was carried out using gas chromatograph Agilent 7890B GC System (Agilent, Santa Clara, CA, USA) with mass spectrometric detector Agilent 5977 BGC/MSD (Agilent, Santa Clara, CA, USA) and chromatographic column DB-5ms (30 m × 250 mkm × 0.25 mkm).

Results. 26 compounds were identified by analysis. Compounds such as n-hexadecanoic acid (16.71 %), 9,12,15-(Z,Z,Z)-octadecatrienoic acid (13.29 %), 2-(4a,8-dimethyl-7-oxo-1,2,3,4,4a,7-hexahydronaphthalen-2-yl)-propionic acid (8.80 %), 8-nitro-(1H)quinolin-4-ol-2-one (6.45 %) and neophytadiene (4.66 %) prevail in tincture. A literature review showed that n-hexadecanoic acid stimulates anti-inflammatory processes in human immune cells through TLR4 receptors, it has antitumor and antidiabetic activity and it also has anti-inflammatory effects. Derivatives of 9,12,15-(Z,Z,Z)-octadecatrienoic acid are used in diabetes therapy. 2-(4a,8-Dimethyl-7-oxo-1,2,3,4,4a,7-hexahydronaphthalen-2-yl)-propionic acid is an immunosuppressant and probably improves tissue insulin sensitivity. In addition, it is necessary to underline the presence of neophytadiene that has an anti-inflammatory effect. The presence of β-phellandrene provides insecticidal and eucalyptol anti-inflammatory effects.

Conclusions. Considering the individual actions of the individual components, Artemisia pontica L. herb can be recommended for further research on its anti-inflammatory, antidiabetic, and antitumor effects.

References

Artemisia pontica L. (n.d.). The Plant List. http://www.theplantlist.org/tpl1.1/record/gcc-3675

Komarov, V. L., Shishkina, B. K., & Bobrova, E. G. (Eds.). (1961). Flora SSSR [Flora of the USSR] (Vol. 26). Izd. Akad. Nauk SSSR. [in Russian].

Maraslavin®. (n.d.). Kompendium - likarski preparaty. https://compendium.com.ua/info/154085/maraslavin-sup-sup-/

Savchenko, L. N., Marinina, T. F., & Lukashuk, S. P. (2012). Sovremennye podkhody k lecheniyu i profilaktiki zabolevanii parodonta [Modern approaches to the treatment and prevention of periodontal disease]. Izvestia of Samara Scientific Center of the Russian Academy of Sciences, 14(5), 758-760. [in Russian].

Chopik, V. I., Dudchenko, L. G., & Krasnova, A. N. (1983). Dikorastushchie poleznye rasteniya Ukrainy [Wild useful plants of Ukraine]. Kiev: Naukova dumka. [in Russian].

Rezaeinodehi, A., & Khangholi, S. (2008). Chemical composition of the essential oil of Artemisia absinthium growing wild in Iran. Pakistan journal of biological sciences : PJBS, 11(6), 946-949. https://doi.org/10.3923/pjbs.2008.946.949

Dhen, N., Majdoub, O., Souguir S., Tayeb, W., Laarif A., & Chaieb, I. (2014). Chemical composition and fumigant toxicity of Artemisia absinthium essential oil against Rhyzopertha dominica and Spodoptera littoralis. Tunisian Journal of Plant Protection, 9(1), 57-65.

Khangholil, S., & Rezaeinodehi, A. (2008). Effect of drying temperature on essential oil content and composition of sweet wormwood (Artemisia annua) growing wild in Iran. Pakistan journal of biological sciences : PJBS, 11(6), 934-937. https://doi.org/10.3923/pjbs.2008.934.937

Altunkaya, A., Yıldırım, B., Ekici, K., & Terzioğlu, Ö. (2014). Determining essential oil composition, antibacterial and antioxidant activity of water wormwood extracts. GIDA, 39(1), 17-24.

Riahi, L., Chograni, H., Elferchichi, M., Zaouali, Y., Zoghlami, N., & Mliki, A. (2013). Variations in Tunisian wormwood essential oil profiles and phenolic contents between leaves and flowers and their effects on antioxidant activities. Industrial Crops and Products, 46, 290-296. https://doi.org/10.1016/j.indcrop.2013.01.036

Msaada, K., Salem, N., Bachrouch, O., Bousselmi, S., Tammar, S., Alfaify, A., Sane, K. A., Ammar, W. B., Azeiz, S., Brahim, A. H., Hammami, M., Selmi, S., Limam, F., & Marzouk, B. (2015). Chemical Composition and Antioxidant and Antimicrobial Activities of Wormwood (Artemisia absinthium L.) Essential Oils and Phenolics. Journal of Chemistry, 2015, Article ID 804658. https://doi.org/10.1155/2015/804658

Judzentiene, A., Budiene, J., Gircyte, R., Masotti, V., & Laffont-Schwob, I. (2012). Toxic Activity and Chemical Composition of Lithuanian Wormwood (Artemisia absinthium L.) Essential Oils. Records of Natural Products, 6(2), 180-183.

Ministry of Health of Ukraine. (1993, September 7). Pro zatverdzhennia Instruktsii po pryhotuvanniu v aptekakh likarskykh form z ridkym dyspersiinym seredovyshchem [About the statement of the Instruction on preparation in drugstores of dosage forms with the liquid dispersion environment (No. 197)]. https://zakon.rada.gov.ua/rada/show/v0197282-93#Text

Talzhanov, N. A., Sadyrbekov, D. T., Smagulova, F. M., Tkachev, A. V., Atazhanova, G. A., Tuleuov, B. I., & Adekenov, S. M. (2005). Components of Artemisia pontica. Chemistry of Natural Compounds, 41, 178-181.

Rzhevskii, S. G., Potapov, M. A., Shikhaliev, Kh. S., & Fedulova, T. P. (2019). Analiz komponentnogo sostava vodnykh ekstraktov Artemisia absinthium L., Artemisia armeniaca Lam., i Artemisia latifolia Ledeb. [Analysis of the component composition of aquatic extracts Artemisia absinthium L., Artemisia armeniaca Lam., and Artemisia latifolia Ledeb.]. Khimiya rastitel'nogo syr'ya, (4), 285-292. [in Russian]. https://doi.org/10.14258/jcprm.2019045149

Khanina, M. A., Serykh, E. A., Korolyuk, A. Yu., Bel'chenko, L. A., Pokrovskii, L. M., & Tkachev, A. V. (2000). Sostav efirnogo masla sibirskikh populyatsii Artemisia pontica L. − perspektivnogo lekarstvennogo rasteniya [Essential oil composition of siberian populations Artemisia pontica L.]. Khimiya rastitel'nogo syr'ya, (3), 85-94. [in Russian].

Derwich E., Benziane Z., Boukir A. (2009). Chemical compositions and insectisidal activity of essential oils of three plants Artemisia SP: Artemisia herba-alba, Artemisia absinthium and Artemisia Pontica (Morocco). Electronic Journal of Environmental, Agricultural and Food Chemistry, 8(11), 1202-1211.

Bos, R., Stojanova, A. St., Woerdenbag, H. J., Koulman, A., & Quax, W. J. (2005). Volatile components of the aerial parts of Artemisia pontica L. grown in Bulgaria. Flavour and Fragrance Journal, 20(2), 145-148. https://doi.org/10.1002/ffj.1399

Korolyuk, E. A., & Tkachev, A. V. (2010). Chemical Composition of the Essential Oil from Two Wormwood Species Artemisia frigida and Artemisia argyrophylla. Russian Journal of Bioorganic Chemistry, 2010, 36(7), 884-893. https://doi.org/10.1134/S1068162010070162

Nicholas, D. A., Zhang, K., Hung, C., Glasgow, S., Aruni, A. W., Unternaehrer, J., Payne, K. J., Langridge, W., & De Leon, M. (2017). Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β. PloS one, 12(5), e0176793. https://doi.org/10.1371/journal.pone.0176793

Thirunavukkarasu, K., Rajkumar, P., Selvaraj, S., & Kumaresan, S. (2016). GC-MS analysis of Gymnema sylvestre leaves methanolic extract for antidiabetic and anticancer drug identification. Journal of Chemical and Pharmaceutical Sciences, 9(2), 1011-1013.

Aparna, V., Dileep, K. V., Mandal, P. K., Karthe, P., Sadasivan, C., & Haridas, M. (2012). Anti-inflammatory property of n-hexadecanoic acid: structural evidence and kinetic assessment. Chemical biology & drug design, 80(3), 434-439. https://doi.org/10.1111/j.1747-0285.2012.01418.x

Matsuo, N., Osada, K., Kodama, T., Lim, B. O., Nakao, A., Yamada, K., & Sugano, M. (1996). Effects of gamma-linolenic acid and its positional isomer pinolenic acid on immune parameters of brown-Norway rats. Prostaglandins, leukotrienes, and essential fatty acids, 55(4), 223-229. https://doi.org/10.1016/s0952-3278(96)90002-2

Christiansen, E., Watterson, K. R., Stocker, C. J., Sokol, E., Jenkins, L., Simon, K., Grundmann, M., Petersen, R. K., Wargent, E. T., Hudson, B. D., Kostenis, E., Ejsing, C. S., Cawthorne, M. A., Milligan, G., & Ulven, T. (2015). Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases. The British journal of nutrition, 113(11), 1677-1688. https://doi.org/10.1017/S000711451500118X

Lee, J. W., Lee, K. W., Lee, S. W., Kim, I. H., & Rhee, C. (2004). Selective increase in pinolenic acid (all-cis-5,9,12-18:3) in Korean pine nut oil by crystallization and its effect on LDL-receptor activity. Lipids, 39(4), 383-387. https://doi.org/10.1007/s11745-004-1242-2

Chen, S. J., Hsu, C. P., Li, C. W., Lu, J. H., & Chuang, L. T. (2011). Pinolenic acid inhibits human breast cancer MDA-MB-231 cell metastasis in vitro. Food chemistry, 126(4), 1708-1715. https://doi.org/10.1016/j.foodchem.2010.12.064

Al-Lahham, S. H., Peppelenbosch, M. P., Roelofsen, H., Vonk, R. J., & Venema, K. (2010). Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms. Biochimica et biophysica acta, 1801(11), 1175-1183. https://doi.org/10.1016/j.bbalip.2010.07.007

Bhardwaj, M., Sali, V. K., Mani, S., & Vasanthi, H. R. (2020). Neophytadiene from Turbinaria ornata Suppresses LPS-Induced Inflammatory Response in RAW 264.7 Macrophages and Sprague Dawley Rats. Inflammation, 43(3), 937-950. https://doi.org/10.1007/s10753-020-01179-z

Cheng, Z., Jiang, J., Yang, X., Chu, H., Jin, M., Li, Y., Tao, X., Wang, S., Huang, Y., Shang, L., Wu, S., Hao, W., & Wei, X. (2017). The research of genetic toxicity of β-phellandrene. Environmental toxicology and pharmacology, 54, 28-33. https://doi.org/10.1016/j.etap.2017.06.011

Juergens, U. R., Dethlefsen, U., Steinkamp, G., Gillissen, A., Repges, R., & Vetter, H. (2003). Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial. Respiratory medicine, 97(3), 250-256. https://doi.org/10.1053/rmed.2003.1432

Juergens, U. R., Engelen, T., Racké, K., Stöber, M., Gillissen, A., & Vetter, H. (2004). Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes. Pulmonary pharmacology & therapeutics, 17(5), 281-287. https://doi.org/10.1016/j.pupt.2004.06.002

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Published

2021-03-18

How to Cite

1.
Panasenko OI, Mozul VI, Denysenko OM, Aksonova II, Oberemko TV. Characteristic of the chemical composition of Artemisia pontica L. CIPM [Internet]. 2021Mar.18 [cited 2023Dec.10];14(1):23-8. Available from: http://pharmed.zsmu.edu.ua/article/view/226743

Issue

Vol. 14 No. 1 (2021)

Section

Original research

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