Biological properties of the major causes factors of purulently inflammatory diseases of surgical patients in Zaporizhzhia Clinical Hospital of Emergency and Critical Care Medicine
Keywords:drug resistance microbial, inflammation, suppuration
The problem of antibiotic resistance of purulent-inflammatory diseases pathogens that arise in patients during treatment in surgery units is urgent and requires a thorough knowledge of the spectrum of circulating strains of microorganisms and changes in the profile of their antibiotic resistance in hospital environment. Detection of resistant strains of microorganisms requires empirical antimicrobial therapy correction and introduction of preventive and anti-epidemic measures.
The study objective is to conduct a retrospective analysis of the clinically significant pathogens circulation and changes in their antibiotic resistance for cases of purulent-inflammatory diseases in patients undergoing treatment in surgery units of Emergency Care Hospital of Zaporizhzhia City Council in 2013–2019.
Materials and methods Using the data of the reporting documentation, we carried out the analysis of the bacteriological studies results for clinical samples obtained from patients who were treated in the surgical departments of the Emergency Care Hospital of Zaporizhzhia in the period from 2013 to 2019. The prevailing pathogens for purulent-inflammatory conditions of patients and the main trends in the antibiotics resistance change of microorganisms have been determined.
Results It has been retrospectively established that for the indicated period 21 301 clinical samples were studied and 21 369 strains of opportunistic microorganisms were isolated. It was determined that the main causative agents of purulent-inflammatory diseases were strains of E. faecalis, S. aureus, E. coli, K. pneumoniae, P. aeruginosa, A. baumannii, while the specific gravity of enterococci was significantly larger than other microorganisms. The sensitivity of these strains to antibiotics underwent annual changes. So, in recent years, the number of vancomycin-resistant enterococci has significantly decreased (from 4 % to 1 %), but the number of methicillin-resistant staphylococci has significantly increased (from 42 % to 82 %). The number of Escherichia and Klebsiella resistant to ceftriaxone (from 49 % to 60 % and from 54 % to 63 %, respectively) and gentamicin (from 46 % to 57 % and from 47 % to 56 %, respectively) increased. 90 % of the strains of acinetobacteria were resistant to fluoroquinolones and carbapenems, 80 % – to amikacin and gentamicin. 80 % of pseudomonad cultures were insensitive to the action of ceftazidime, cefepime, carbapenems, 90 % to the action of fluoroquinolones, 60 % to the action of aminoglycosides.
Conclusion. Monitoring the circulation of the main pathogens of purulent-inflammatory diseases with the determination of the spectrum of resistance of the isolated microorganism strains to antibiotics is one of the stages of substantiation of empirical antibacterial therapy within the hospital.
Peretyatko, E. G. (2013). Rol enterokokiv u vynyknenni nozokomialnykh infektsii (ohliad literatury) [Role of enterococci in the occurrence of nosocomial infections]. Annals of Mechnikov Institute, (4), 22-27. [in Ukrainian].
Palkovsky, O. L., Alekseyeva, L. A., & Shimanov, I. S. (2015). Problemy terapii nozokomial’noi enterokokkovoi infektsii (obzor literatury) [The problems of therapy of nosocomial enterococcal infection (literature review)]. Problemy zdorov’ya i ekologii, (4), 4-8. [in Russian].
Fadeev, S. B. (2018). Kliniko-bakteriologicheskie osobennosti gnoino-nekroticheskikh protsessov myagkikh tkanei stafilokokkovoi etiologii u bol’nykh sakharnym diabetom ІІ tipa i patsientov, ne stradayushchikh diabetom [Сlinical and bacteriological features of purulent-necrotic processes of soft tissues of staphylococcal etiology in patients with type ii diabetes mellitus and non-diabetic patients]. Sovremennye problemy nauki i obrazovaniya, (6). [in Russian]. https://doi.org/10.17513/spno.28350
Nazarchuk, O. A. (2016). Antyseptyky: suchasna stratehiia borotby si zbudnykamy infektsiinyh uskladnen [Аntiseptics: modern strategy of struggle with causing agents of the іnfection complications]. Klinichna khirurhiia, (9), 59-62. [in Ukrainian].
Shchuplova, E. A., & Fadeev, S. B. (2016). Izuchenie vydovoho sostava mikroflory ochagov hnoyino-vospalytelʹnykh protsesjv c ispolzovaniem raznykh metodycheskih podkhodov [The study of species composition of microflora focal inflammatory processes using different methodological approaches]. Byulleten’ Orenburgskogo nauchnogo tsentra UrO RAN, (2), 1-8. [in Russian].
Prevar, A. P., Kryzshanovskaya, A. V., Radionov, V. A., & Mrug, V. M. (2018). Analiz monitorynhovoho doslidzhennia antybiotykorezystentnosti zbudnykiv hniino-zapalnykh protsesiv miakykh tkanyn [Analysis of the monitoring study of the antibiotic-resistance of the agents of purulent-inflammatory processes of soft tissue]. Visnyk Vinnytskoho natsionalnoho medychnoho universytetu, 22(2), 285-288. [in Ukrainian]. https://doi.org/10.31393/reports-vnmedical-2018-22(2)-10
Babichev, S. A. Arhipenko, M. V., Adonina, E. A., Malysheva, T. V., Vyatkina, G. G., Krolichenko, T. P., Seyuhova, F. S., Kachanova, O. A., & Naumov G. N. (2017). Osnovnye vozbuditeli gnoino-vospalitel’nykh oslozhnenii u bol’nykh s zabolevaniyami pochek iz otdeleniya reanimatsii i intensivnoi terapii kraevoi klinicheskoi bol’nitsy № 1 [The basic agents of pyoinflammatory complications in patients with kidney disease from the department of resuscitation and intensive therapy regional clinical hospital № 1]. Kubanskii nauchnyi meditsinskii vestnik, (2), 18-20. [in Russian]. https://doi.org/10.25207/1608-6228-2017-2-18-20
Spakhi, O. V., & Paholchuk, A. P. (2016). Osobennosti bakteriologicheskogo spektra infitsirovannykh i gnoinykh ran u detei [Features bacteriological spectrum infected and purulent wounds in children]. Sovremennaya pediatriya, (4), 120-123. [in Russian].https://doi.org/10.15574/SP.2016.76.120
Kondratyuk, V. M., Bogush, G. L., Fomin, A. A., Tomchuk, S. V., & Bektemirova, R. M. (2016). Mikroflora boiovykh ran kintsivok, yaki oderzhani v khodi antyterrorystychnoi operatsii, u poranenykh, shcho prokhodyly likuvannia v VMKC CR Vinnytsia [The microflora of combat wounds of limbs obtained in the course of the antiterrorist operation, in the wounded treated in Vinnitsa MMCC CR]. Kharkivska khirurhíchna shkola, (2), 80-83. [in Ukrainian].
Lazareva, A. V., Tchebotar, I. V., Kryzhanovskaya, O. A., Tchebotar, V. I., & Mayanskiy, N. A. (2015). Pseudomonas aeruginosa: patogennost’, patogenez i patologiya [Pseudomonas aeruginosa: Pathogenicity, Pathogenesis and Diseases]. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya, 17(3), 170-186. [in Russian].
Bondarenko, V. M. (2013). Mekhanizmy translokatsii bakterialnoy autoflory v razvitii endogennoy infektsii [Mechanisms of a translocation of bacterial authorflora in development of endogenous infections]. Byulleten’ Orenburgskogo nauchnogo tsentra UrO RAN, (3), 1-21. [in Russian].
Chebotar, I. V., Lazareva, A. V., Masalov, Ya. K., Mikhailovich, V. M., & Mayanskiy, N. A. Acinetobacter: mikrobiologicheskiye, patogeneticheskiye i rezistentniye svoystva [Acinetobacter: Microbiological, Pathogenetic and Resistant Properties]. Vestnyk rossyyskoy akademiyi medytsynskykh nauk, 2014, (9-10), 39-50. [in Russian]. https://doi.org/10.15690/vramn.v69i9-10.1130
Mizuno, Y., Shirahashi, K., Yamamoto, H., Matsumoto, M., Miyamoto, Y., Komuro, H., Doi, K., & Iwata, H. (2019). Preoperative screening for nasal carriage of methicillin-resistant Staphylococcus aureus in patients undergoing general thoracic surgery. Journal of rural medicine : JRM, 14(1), 73-77. https://doi.org/10.2185/jrm.2987
World Health Organization. (2018). Web Appendix 4. Summary of a systematic review on screening for extended spectrum beta-lactamase and the impact on surgical antibiotic prophylaxis. In Global Guidelines for the Prevention of Surgical Site Infection. https://www.who.int/gpsc/appendix4.pdf?ua=1
How to Cite
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)