Derivatografic study of the ointment with piroctone olamine for therapy and prevention of seborrheic dermatitis

Authors

DOI:

https://doi.org/10.14739/2409-2932.2020.2.207184

Keywords:

piroctone olamine, excipients, ointments, thermogravimetry, pharmaceutical technology

Abstract

 

Piroctone olamine (octopirox) has a wide spectrum of antibacterial activity against gram-positive and gram-negative pathogenic microorganisms together with the expressed antimycotic action. Octopirox is characterized by good tolerance and harmlessness and, also, deodorizing effect when applying topically. Besides, the composition of piroctone olamine with designed naphthalan in the formula of the ointment for external use should be perspective. Designed naphthalan is a natural ingredient with mineral nature and has desensitizing, anti-inflammatory, analgesic, reabsorbable, anti-itch, warming, and antibacterial effects.

By the staff members of the department of Medicines Technology of Zaporizhzhia State Medical University a compositional formula of the ointment with piroctone olamine and designed naphthalan for topical therapy of patients with seborrheic dermatitis, accompanied by scalp damage, was proposed on the base of complex investigations. It is predicted that the administration of the developed pharmacotherapeutic agent should enhance the normalization of lipid mantle, keratinization, desquamation, overcoming itch, and skin inflammatory.

The aim of this work is to study of impacts of thermal handling of the compositional trichological ointment on the hydrophilic base at temperature interval of the technological process of manufacturing this dosage form.

Materials and methods. As objects of derivatografic investigations, the experimental ointment for topical administration and, also, active components (piroctone olamine, deresined naphthalan) and excipients of this ointment (sodium carboxymethylcellulose, glycerol, twin 80, propylene glycol) were used. Thermogravimetric analysis was carried out using derivatograph “Shimadzu DTG-60” (Japan) with the platinum and platinum-rhodium thermopair.

Results. Data on thermogravimetric analysis clearly demonstrate the thermal stability of the active pharmaceutical ingredients and excipients in the investigating dosage form. Derivatograms of the ointment with piroctone olamine and it was hydrophilic vehicle-placebo show a matching of their thermal effects with the same of the active substance and excipients. That fact indicates the absence of chemical interactions between them.

Conclusions. It was established that ingredients of the developed semisolid dosage form for topical therapy of seborrheic dermatitis with piroctone olamine on the hydrophilic base have not done interact with each other and, so, this composition has been a mechanical mixture of active substances and excipients. It was revealed that, according to thermal effects of the ingredients of the developed ointment for external use, the technological process of its manufacturing would be appropriate at a temperature below 90°С.

 

References

Borda, L. J., & Wikramanayake, T. C. (2015). Seborrheic Dermatitis and Dan-druff: A Comprehensive Review. Journal of clinical and investigative dermatology, 3(2), https://doi.org/10.13188/2373-1044.1000019

Albanova, V. I., & Kalinina, O. V. (2015). Seboreinyi dermatit volosistoi chasti golovy: rol’ Mallassezia [Seborrheic dermatitis of hairy part of head : role of Mallassezia]. Uspekhi meditsinskoi mikologii, 14, 11-13. [in Russian].

Solodovnik, V. A., Tkachenko, N. O., Gladysheva, S. А., & Fadi Al Zedan. (2018). Doslidzhennia rynku zasobiv dlia likuvannia seboreinoho dermatytu volosystoi chastyny holovy [Study of medicines’ market for the treatment of seborrheic dermatitis of the pilar part of head]. Current Issues in Pharmacy and Medicine: Science and Practice, 11(1), 112-118. [in Ukrainian]. https://doi.org/10.14739/2409-2932.2018.1.123730

Olisova, O. Yu. (2016). Patogenez i lechenie seboreinogo dermatita [Pathogeny and treatment of seborrheic dermatitis]. Effektivnaya farmakoterapiya, (1-2), 36-40. [in Russian].

Gadegone, S. M., Misar, K. S., & Ingle, B. (2019). Formulation, development and evaluation of anti-dandruff shampoo using piroctone olamine. International Journal of Biochemistry and Biomolecules, 5(1), 1-5.

Kasikhina, E. I. (2017). Vozmozhnosti lecheniya i profilaktiki retsidivov poverkhnostnykh mikozov kozhi [Possibilities of treatment and prophylaxis of relapses of superficial mycosiss of skin]. Russkii meditsinskii zhurnal, 25(11). 854-858. [in Russian].

Adigozalova, V. A. (2016). Unikal’naya neft’ Naftalanskogo mestorozhdeniya Azerbaidzhana. II. Izuchenie biologicheskikh svoistv naftalanskoi nefti i ee de-istviya na organizm [Unique Naftalan oil fields of Azerbaijan II. The study of the biological properties of Naftalan oil and its effect on human body]. Istoriya i pedagogika estestvoznaniya, (3), 39-45. [in Russian].

Shevtsova, A. S. (2017). Analiz kriticheskikh tochek polucheniya krema-bal’zama s natural’noi naftalanskoi neft’yu [Analysis of critical points of receipt of cream-balsam with natural Naftalan oil]. Zdorov’e i obrazovanie v XXI veke, 19(10), 363-366. [in Russian].

Gladyshev, V. V., Solodovnik, V. A., Lisianskaia, A. P., & Gladyshevа, S. A. (2019). Study of intensity of the octopirox releasing from the ointment bases. Polish Journal of Science, 1(19), 25-29. [in Russian].

Solodovnik, V. A., Gladyshev, V. V., & Lisianskaia, A. P. (2019). Izuchenie konsistentnykh svoistv mazei s oktopiroksom [Study of Consistent Characteristics of the Ointment with Octopyrox]. Current Issues in Pharmacy and Medicine: Science and Practice, 12(1), 36-41. [in Russian]. https://doi.org/10.14739/2409-2932.2019.1.158990

Khromylova, O. V. (2019). Derivatograficheskie issledovaniia tiotriazolina, L-arginina, smesi L-arginina s tiotriazolinom [Derivatographic Studies of Thiotriazoline, L-arginine and L-arginine and Thiotriazoline Mixture]. Retsept, 22(4), 544-549. [in Russian].

Kuchina, L. K., Gladyshev, V. V., & Pukhalskaya, I. A. (2015). Termogravimetricheskie issledovaniia gelia nasalnogo s diltiazemom [Thermogravimetric investigations of nasal gel with diltiazem]. Current Issues in Pharmacy and Medicine: Science and Practice, 19(3), 30-33. [in Russian]. https://doi.org/10.14739/2409-2932.2015.3.52622

How to Cite

1.
Solodovnyk VA, Hladyshev VV, Burlaka BS, Pukhalska IO. Derivatografic study of the ointment with piroctone olamine for therapy and prevention of seborrheic dermatitis. Current issues in pharmacy and medicine: science and practice [Internet]. 2020Jul.3 [cited 2024Mar.29];13(2). Available from: http://pharmed.zsmu.edu.ua/article/view/207184

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Original research