Study of surfactants influence on the noopept releasing from the nasal dosage form

Authors

  • B. S. Burlaka Zaporizhzhia State Medical University, Ukraine,
  • I. F. Bielenichev Zaporizhzhia State Medical University, Ukraine,
  • V. V. Hladyshev Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2409-2932.2020.1.198183

Keywords:

surfactants, noopept, releasing, nasal dosage form

Abstract

 

The nasal route of drug administration, as is well known, is characterized by some advantages: absorption rate and rapid onset of therapeutic effect, availability of drug delivery without hepatic first-pass elimination, it is suitable and easily accessible. Earlier a medication for nasal administration with noopept – a low toxic substance with peptide nature without any side effects and high activity has been developed.

After advance investigations, a solution of sodium carboxymethylcellulose providing the highest rate of noopept releasing was chosen as a delivery base.

The aim of work the study of surfactants' influence on the noopept releasing from the nasal dosage form.

Materials and methods. For the investigation, the compositions containing twin-80 from 0 % to 3 % were prepared. Surfactant was added to the nasal dosage form containing noonpept 1 %, glycerol, and bishofit poltavsky equally by 5 % and solution of sodium carboxymethylcellulose. Noopept releasing was studied using the method of equilibrium dialysis by Kruvchinsky through the semipermeable membrane – cellophane film “Kuprofan” after 30 minutes. Noopept concentration was determined by the UV-spectrophotometry at 258 nm. 

Results. Results of investigation have verified that the addition of twin-80 to nasal dosage form with noopept provides with a better level of releasing of the active substance. At the same time, increasing of concentration more than 1 % hasn’t a significant influence on the noopept releasing.

Conclusions. It was determined that the content of twin-80 has a significant influence on a noopept releasing from the nasal dosage forms. The concentration of twin-80 1 % provides optimal releasing.

 

References

Bhise, S. B., Yadav, A. V., Avachat, A. M., & Malayandi, R. (2008). Bioavailability of intranasal drug delivery system. Asian Journal of Pharmaceutics, 2(4), 201-215. https://doi.org/10.4103/0973-8398.45032

Kushwaha, S. K. S., Keshari, R. K., & Rai, A. K. (2011). Advances in nasal trans-mucosal drug delivery. Journal of Applied Pharmaceutical Science, 1(7), 21-28.

Ostrovskaya, R. U., Gudasheva, T. A., Voronina, T. A., & Seredenin, S. B. (2002). Original'nyi nootropnyi i neiroprotektivnyi preparat noopept [The novel nootropic and neuroprotector drug noopept (GVS-111)]. Eksperimental'naya i klinicheskaya farmakologiya, 65(5), 66-72. [in Russian]. https://doi.org/10.30906/0869-2092-2002-65-5-66-72

Amelin, A. V., Iliukhina, A. Iu., & Shmonin, A. A. (2011). Noopept v lechenii umerennykh kognitivnykh narushenii u patsientov s ishemicheskim insul'tom [Noopept in the treatment of mild cognitive impairment in patients with stroke]. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova, 111(10), 44-46. [in Russian].

Sharma, S., Kulkarni, J., & Pawar, A. P. (2006). Permeation enhancers in the transmucosal delivery of macromolecules. Pharmazie, 61(6), 495-504.

Thorat, S. (2016). Formulation and Product Development of Nasal Spray: An Overview. Scholars Journal of Applied Medical Sciences, 4(8D), 2976-2985. https://doi.org/10.21276/sjams.2016.4.8.48

Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (2009). Handbook of Pharmaceutical Excipients. (6th ed.). London: Pharmaceutical Press.

Hroshovyi, T. A., Martseniuk, V. P., Kucherenko, L. I., Vronska, L. P., & Hureieva, S. M. (2008). Matematychne planuvannia eksperymentu pry provedenni naukovykh doslidshen v farmatsii [The mathematical planning of experiment is during realization of scientific researches in pharmacya]. Ternopil: TDMU. [in Ukrainian].

Antypenko, L., Burlaka, B., & Belenichev, I. (2016). Noopept: development and validation of a UV-Vis spectrophotometric method for the quantification of (S)-N-phenylacetyl-L-prolylglycine ethyl ester in bulk drug substance. Pharmakeftiki, 28(4), 161-169.

Downloads

How to Cite

1.
Burlaka BS, Bielenichev IF, Hladyshev VV. Study of surfactants influence on the noopept releasing from the nasal dosage form. Current issues in pharmacy and medicine: science and practice [Internet]. 2020Mar.10 [cited 2024Dec.23];13(1). Available from: http://pharmed.zsmu.edu.ua/article/view/198183

Issue

Vol. 13 No. 1 (2020)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.     Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)