Study of surfactants influence on the noopept releasing from the nasal dosage form

Authors

  • B. S. Burlaka Zaporizhzhia State Medical University, Ukraine,
  • I. F. Bielenichev Zaporizhzhia State Medical University, Ukraine,
  • V. V. Hladyshev Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2409-2932.2020.1.198183

Keywords:

surfactants, noopept, releasing, nasal dosage form

Abstract

 

The nasal route of drug administration, as is well known, is characterized by some advantages: absorption rate and rapid onset of therapeutic effect, availability of drug delivery without hepatic first-pass elimination, it is suitable and easily accessible. Earlier a medication for nasal administration with noopept – a low toxic substance with peptide nature without any side effects and high activity has been developed.

After advance investigations, a solution of sodium carboxymethylcellulose providing the highest rate of noopept releasing was chosen as a delivery base.

The aim of work the study of surfactants' influence on the noopept releasing from the nasal dosage form.

Materials and methods. For the investigation, the compositions containing twin-80 from 0 % to 3 % were prepared. Surfactant was added to the nasal dosage form containing noonpept 1 %, glycerol, and bishofit poltavsky equally by 5 % and solution of sodium carboxymethylcellulose. Noopept releasing was studied using the method of equilibrium dialysis by Kruvchinsky through the semipermeable membrane – cellophane film “Kuprofan” after 30 minutes. Noopept concentration was determined by the UV-spectrophotometry at 258 nm. 

Results. Results of investigation have verified that the addition of twin-80 to nasal dosage form with noopept provides with a better level of releasing of the active substance. At the same time, increasing of concentration more than 1 % hasn’t a significant influence on the noopept releasing.

Conclusions. It was determined that the content of twin-80 has a significant influence on a noopept releasing from the nasal dosage forms. The concentration of twin-80 1 % provides optimal releasing.

 

References

Bhise, S. B., Yadav, A. V., Avachat, A. M., & Malayandi, R. (2008). Bioavailability of intranasal drug delivery system. Asian Journal of Pharmaceutics, 2(4), 201-215. https://doi.org/10.4103/0973-8398.45032

Kushwaha, S. K. S., Keshari, R. K., & Rai, A. K. (2011). Advances in nasal trans-mucosal drug delivery. Journal of Applied Pharmaceutical Science, 1(7), 21-28.

Ostrovskaya, R. U., Gudasheva, T. A., Voronina, T. A., & Seredenin, S. B. (2002). Original'nyi nootropnyi i neiroprotektivnyi preparat noopept [The novel nootropic and neuroprotector drug noopept (GVS-111)]. Eksperimental'naya i klinicheskaya farmakologiya, 65(5), 66-72. [in Russian]. https://doi.org/10.30906/0869-2092-2002-65-5-66-72

Amelin, A. V., Iliukhina, A. Iu., & Shmonin, A. A. (2011). Noopept v lechenii umerennykh kognitivnykh narushenii u patsientov s ishemicheskim insul'tom [Noopept in the treatment of mild cognitive impairment in patients with stroke]. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova, 111(10), 44-46. [in Russian].

Sharma, S., Kulkarni, J., & Pawar, A. P. (2006). Permeation enhancers in the transmucosal delivery of macromolecules. Pharmazie, 61(6), 495-504.

Thorat, S. (2016). Formulation and Product Development of Nasal Spray: An Overview. Scholars Journal of Applied Medical Sciences, 4(8D), 2976-2985. https://doi.org/10.21276/sjams.2016.4.8.48

Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (2009). Handbook of Pharmaceutical Excipients. (6th ed.). London: Pharmaceutical Press.

Hroshovyi, T. A., Martseniuk, V. P., Kucherenko, L. I., Vronska, L. P., & Hureieva, S. M. (2008). Matematychne planuvannia eksperymentu pry provedenni naukovykh doslidshen v farmatsii [The mathematical planning of experiment is during realization of scientific researches in pharmacya]. Ternopil: TDMU. [in Ukrainian].

Antypenko, L., Burlaka, B., & Belenichev, I. (2016). Noopept: development and validation of a UV-Vis spectrophotometric method for the quantification of (S)-N-phenylacetyl-L-prolylglycine ethyl ester in bulk drug substance. Pharmakeftiki, 28(4), 161-169.

How to Cite

1.
Burlaka BS, Bielenichev IF, Hladyshev VV. Study of surfactants influence on the noopept releasing from the nasal dosage form. Current issues in pharmacy and medicine: science and practice [Internet]. 2020Mar.10 [cited 2024Dec.3];13(1). Available from: http://pharmed.zsmu.edu.ua/article/view/198183

Issue

Section

Original research