Study of surfactants influence on the noopept releasing from the nasal dosage form

Authors

  • B. S. Burlaka Zaporizhzhia State Medical University, Ukraine,
  • I. F. Bielenichev Zaporizhzhia State Medical University, Ukraine,
  • V. V. Hladyshev Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2409-2932.2020.1.198183

Keywords:

surfactants, noopept, releasing, nasal dosage form

Abstract

 

The nasal route of drug administration, as is well known, is characterized by some advantages: absorption rate and rapid onset of therapeutic effect, availability of drug delivery without hepatic first-pass elimination, it is suitable and easily accessible. Earlier a medication for nasal administration with noopept – a low toxic substance with peptide nature without any side effects and high activity has been developed.

After advance investigations, a solution of sodium carboxymethylcellulose providing the highest rate of noopept releasing was chosen as a delivery base.

The aim of work the study of surfactants' influence on the noopept releasing from the nasal dosage form.

Materials and methods. For the investigation, the compositions containing twin-80 from 0 % to 3 % were prepared. Surfactant was added to the nasal dosage form containing noonpept 1 %, glycerol, and bishofit poltavsky equally by 5 % and solution of sodium carboxymethylcellulose. Noopept releasing was studied using the method of equilibrium dialysis by Kruvchinsky through the semipermeable membrane – cellophane film “Kuprofan” after 30 minutes. Noopept concentration was determined by the UV-spectrophotometry at 258 nm. 

Results. Results of investigation have verified that the addition of twin-80 to nasal dosage form with noopept provides with a better level of releasing of the active substance. At the same time, increasing of concentration more than 1 % hasn’t a significant influence on the noopept releasing.

Conclusions. It was determined that the content of twin-80 has a significant influence on a noopept releasing from the nasal dosage forms. The concentration of twin-80 1 % provides optimal releasing.

 

References

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How to Cite

1.
Burlaka BS, Bielenichev IF, Hladyshev VV. Study of surfactants influence on the noopept releasing from the nasal dosage form. Current issues in pharmacy and medicine: science and practice [Internet]. 2020Mar.10 [cited 2024Jun.21];13(1). Available from: http://pharmed.zsmu.edu.ua/article/view/198183

Issue

Section

Original research