Study of influence of base-vehicle on biological activity of vasopressin in the transbuccal dosage forms
DOI:
https://doi.org/10.14739/2409-2932.2019.3.184199Keywords:
vasopressin, buccal films, base-vehicle, nootropic activity, administration buccalAbstract
Understanding of nootropics' lack of strong selectivity is a feature of their study at the modern stage. Speaking about peptides such as vasopressin, influence on the related behavioral forms including linked with a mental and emotional area is also presented in this range. At the same time, the systemic administration of peptides was additionally complicated by the high rate of biodegradation and low bioavailability. In this regard, using the alternative transbuccal route of administration is more perspective for the vasopressin derivatives.
The aim of this work is study of influence of base-vehicle in the buccal films with vasopressin on its nootropic activity.
Materials and methods. Hydrophilic bases with a high rate of biodegradation in the oral cavity were studied as devices for vasopressin buccal form. Synthetic decapeptide analog of vasopressin – diglycine-dezglycinamid-arginine-vasopressin – was used as an active substance. Technology of two-layer films was used for the improvement of the dose uniformity and prolongation of effect, taking into account the insignificant amount of vasopressin in the dosage form.
Further research to scientific substantiation of the base-vehicle for transbuccal dosage form with vasopressin was carried out according to the plan of single-factor analysis of variance with repeated observations. Specific activity in the form of a latency period of the conditioned response of passive avoidance was established for all selected compositions in nonamnestic white rats after the administration of buccal films.
Results. According to obtained data, a sort of investigated matrix bases makes a significant influence on the latency period of the conditioned response of passive avoidance in nonamnestic white rats after the administration of buccal films with vasopressin. Allowed to build the next Preferred range of films’ vehicles influence on the parameter of optimization was built using the Dunkan’s multiple rank test.
Conclusions. It was established that the sort of base-vehicle makes a significant influence on the biological activity of vasopressin in the transbuccal dosage forms. Variance analysis of results has shown that buccal films with vasopressin on the gelatin and sodium carboxymethylcellulose bases provide the optimal nootropic effect.
References
Belokoskova, S. G., Stepanov, I. I., & Cikunov S. G. (2012). Agonist V2-receptorov vazopressina reduciruet depressivnye rasstrojstva u postinsultnyh bolnyh [Agonist of V2 vasopressin receptor reduces depressive disorders in post-stroke patients]. Annals of the Russian Academy of medical sciences, 67(4), 40-44. [in Russian].
Yazir, Y., Utkan, T., Gacar, N., & Aricioglu, F. (2015). Resveratrol exerts anti-inflammatory and neuroprotective effects to prevent memory deficits in rats exposed to chronic unpredictable mild stress. Physiology & Behavior, 138, 297-304. doi: 10.1016/j.physbeh.2014.10.010
Forsberg, E., Shelley-Egan, C., Thorstensen, E., Landeweerd, L., & Hofmann, B. (2017). Ethical Concerns in HCE: The Examples of Cognitive Enhancing Drugs and Noninvasive Brain Stimulation. Evaluating Ethical Frameworks For The Assessment Of Human Cognitive Enhancement Applications, 15-29. doi: 10.1007/978-3-319-53823-5_3
Drozdov, A. L., Rodinskij, A. G. & Svirgun, I. S. (2018). Psikhicheskoe otrazhenie v teorii funkcionalnyh sistem [A psychical reflection is in the theory of the functional systems]. Uchebnoe posobie. Dnepr. [in Russian].
Dzjak, G. V., Gluh, A. I., Gluh, I. S., Drozdov, A. L., Zubkovskaja, A. G., & Rodinskij, A. G. et al. (2015). Neirotropnye svojstva lecetina podsolnechnika [Neurotropic properties of sunflower lecithin]. Metodicheskoe posobie. Dnepr. [in Russian].
Gräff, J., & Tsai, L. (2013). The potential of HDAC inhibitors as cognitive enhancers. Annual Review Of Pharmacology And Toxicology, 53, 311-330. doi: 10.1146/annurev-pharmtox-011112-140216
Logvinov, I. O., Antipova, T. A., Gudasheva, T. A., Tarasjuk, A. V., Antipov, P. I., & Seredenin S. B. (2013). Nejroprotektivnye svojstva dipeptidnogo mimetika mozgovogo nejrotroficheskogo faktora GSB-106 v jeksperimentah in vitro [Neuroprotective effects of dipeptide analogue of brain-derived neurotrophic factor GSB-106 in vitro experiments]. Bulletin of Experimental Biology and Medicine, 155(3), 319-322 [in Russian].
Erofeeva L. N. (2018). Lеkarstvennye plenki. Istorija i sovremennost [Medicinal tapes. History and contemporaneity]. University science: look in the future: Proceedings of the International Scientific Conference. (Vol. 2. pp. 52-57). Kursk. [in Russian].
Batyrbekov E. O. (2014). Polymernye plenki s prolongirovannym obezbolivajushhim dejstviem [Polymer films with the prolonged anesthetic effect]. Eighth international Beremzhanovskii convention on chemistry and chemical technology. Proceedings of the 8th International congress/ (Part 1. pp. 183-187). Ust-Kamenogorsk. [in Russian].
Mustafin, R. I., Garipova, V. R., Selmin, F., & Cirulzo F. (2015). Dispergiruemye v rotovoj polosti lekarstvennye formy (obzor) [Orodispersible dosage forms (review)]. Drug development & registration, 4, 34-38. [in Russian].
Shestakov, N. V., Losenkova, S. O., Zakaljukina, E. V. & Stepanova, Je. F. (2017). Assortiment i harakteristiki transmukozalnyh lekarstvennyh form (assortiment lekarstvennyh plenok) [Range and characteristics transmucosal dosage forms]. Drug development & registration, 2, 96-101. [in Russian].
Pankrusheva, T. A., Erofeeva, L. N., Maravina, I. N., Chekmareva, M. S., Avtina, T. V., & Avtina, N. V. (2014). Polymernye lekarstvennye plenki dlja lechenija zabolevanij slizistyh obolochek [Polymeric medicinal films for the treatment of diseases of the mucous membranes]. Scientific notes of Orel State University, 7(63), 211-212. [in Russian].
Piskunov, S. Z. & Erofeeva, L. N. (2015). Razrabotka i issledovanie plenok dlja lechenija rinitov [Design and investigation of rhinitis-curing films]. Russian Rhinology, 3, 54-56. doi: 10.17116/rosrino201523354-56 [in Russian].
Sakipova, Z. B., Zheterova, S. R., & Blatov, R. M. (2013). Razrabotka sostava i tehnologii proizvodstva bukkalnoj plenki s acetilsalicilovoj kislotoj [Development of composition and technology of buccal film with acetylsalicylic ACID]. Vestnik KazNMU, 4(1), 310-318. [in Russian].
Sampiev, A. M., Nikiforova, E. B., & Sopovskaia, A. V. (2016). Sovremennoe sostojanie issledovanij v oblasti sozdanija stomatologicheskih plenok [Current status of the study of dental films]. International journal of applied and fundamental research, 3, 293-297. [in Russian].
Marinina, T. F., & Gjulbjakova, H. N. (2014). Razrabotka tehnologii i analiz dvuhslojnyh stomatologicheskih plenok protivovospalitelnogo i anestezirujushhego dejstvija [Development of technology and analysis of two-layer of dental membranes anti-inflammatory and anesthetic]. Modern problems of science and education, 4. [in Russian].
Hroshovyi, T. A., Martseniuk, V. P., Kucherenko, L. I., Vronska, L. P. & Hureieva S. M. (2008). Matematychne planuvannia eksperymentu pry provedenni naukovykh doslidzhen v farmatsii [Mathematical planning of experiment when conducting scientific research in pharmacy]. Ternopil. [in Ukrainian].
Al Nukari Abdulkarim, & Drozdov, O. L. (2016). Vyvchennia vplyvu osnov-nosiiv na biolohichnu aktyvnist vazopresynu v nazalnykh likarskykh formakh [Study of influence of bases-carriers on biological activity оf vasopressin in nasal dosage forms]. Pharmaceutical journal, 2, 65-69. [in Ukrainian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
