Development of determination method and study of piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio) acetate in milk of cows in 12 hours after administration
DOI:
https://doi.org/10.14739/2409-2932.2019.2.171265Keywords:
liquid chromatography-mass spectrometry, 1, 2, 4-triazole, Trifuzol-neo, cow’s milkAbstract
The purpose of our work was developing the HPLC-MS method for determining piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio) acetate and researching the presence of residual amounts of piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio) acetate in cow’s milk in 12 hours after injection.
Materials and methods. Agilent 1260 Infinity Liquid Chromatography System (degasser, binary pump, autosampler, column thermostat, diode array detector, single quadrupole mass spectrometer Agilent 6120.
Results. The method of determination of piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio) acetate in cow’s milk was developed and the residual amounts of piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio) acetate in cow’s milk in 12 hours after injection was determined.
Conclusions. The conditions for sample preparation of milk samples for the determination of piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetate have been proposed. It was found that 0.5 % methanoic acid is the most favorable protein precipitation agent. The content of the medicinal substance in the cow’s milk sample was measured in 12 hours after the injection of the 1 % solution.
References
Yang, G., Huang, X., Guo, C., Fang, Q., & He, L. (2013). Determination of clavulanic acid residue in milk by high performance liquid chromatography-tandem mass spectrometry. Chinese Journal Of Chromatography, 30(6), 568–571. doi: 10.3724/sp.j.1123.2012.02003
Denžić Lugomer, M., Pavliček, D., Bilandžić, N., & Majnarić, D. (2017). Determination of benzimidazole residues and their metabolites in raw milk using high performance liquid chromatography-diode array detection. Mljekarstvo, 31(3), 231–238. doi: 10.15567/mljekarstvo.2017.0308
Wang, W., Huang, X., Wang, H., Yan, C., & Kong, X. (2013). Determination of phenolic and salicylanilide anthelmintics in liquid milk by high performance liquid chromatography. Chinese Journal Of Chromatography, 31(10), 1028. doi: 10.3724/sp.j.1123.2013.03006
Hou, X., Wu, Y., Lv, Y., Xu, X., Zhao, J., & Yang, T. (2013). Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for determination of 10 cephalosporins and desacetylcefapirin in milk. Journal Of Chromatography B, 931, 6–11. doi: 10.1016/j.jchromb.2013.05.006
Gong, Q., Ding, L., Zhu, S., Jiao, Y., Cheng, J., Fu, S., & Wang, L. (2013). Determination of ten aminoglycoside residues in milk and dairy products using high performance liquid chromatography-tandem mass spectrometry. Chinese Journal Of Chromatography, 30(11), 1143–1147. doi: 10.3724/sp.j.1123.2012.06024
Moudgil, P., Bedi, J., Aulakh, R., Gill, J., & Kumar, A. (2018). Validation of HPLC Multi-residue Method for Determination of Fluoroquinolones, Tetracycline, Sulphonamides and Chloramphenicol Residues in Bovine Milk. Food Analytical Methods, 12(2), 338–346. doi: 10.1007/s12161-018-1365-0
Al-Afy, N., Sereshti, H., Hijazi, A., & RashidiNodeh, H. (2018). Determination of three tetracyclines in bovine milk using magnetic solid phase extraction in tandem with dispersive liquid-liquid microextraction coupled with HPLC. Journal Of Chromatography B, 1092, 480–488. doi: 10.1016/j.jchromb.2018.06.049
Sagirli, O., Demirci, S., & Önal, A. (2015). A very simple high-performance liquid chromatographic method with fluorescence detection for the determination of gemifloxacin in human breast milk. Luminescence, 30(8), 1326–1329. doi: 10.1002/bio.2901
Nebot, C., Regal, P., Miranda, J., Fente, C., & Cepeda, A. (2013). Rapid method for quantification of nine sulfonamides in bovine milk using HPLC/MS/MS and without using SPE. Food Chemistry, 141(3), 2294–2299. doi: 10.1016/j.foodchem.2013.04.099
Zhang, J., Li, W., Zhu, W., Yang, Y., Qin, P., Zhou, Q., et al. (2019). Mesoporous graphitic carbon nitride as an efficient sorbent for extraction of sulfonamides prior to HPLC analysis. Mikrochim Acta, 186(5), 279. doi: 10.1007/s00604-019-3394-9
Varynskyi, B., Knysh, Y., Parchenko, V., Panasenko, O., & Kaplaushenko, A. (2015). Quantitative analysis of piperidin-1-ium {[5-(2-furyl)-4-phenyl-4h-1,2,4-triazol-3-yl]thio}acetate, substance of the veterinary drug “tryfuzol”, in poultry meat by LC–DAD–MS. Current issues in pharmacy and medicine: science and practice, 2, 25–31. doi: 10.14739/2409-2932.2015.2.45242
Varynskyi, B., Knysh, Y., Parchenko, V., Panasenko, O., & Kaplaushenko, A. (2016). Development and validation of a LC-ESI-MS method for detection of piperidin-1-ium {[5-(2-furyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio}acetate residues in poultry eggs. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 40(3), 29–40. doi: 10.1501/eczfak_0000000586
Varynskyi, B. O., Parchenko, V. V., & Kaplaushenko, А. G. (2017). Development and validation of HPLC-DAD method of determination piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetate in 1 % solution. Zaporozhye medical journal, 19, 6(105), 827–832. doi: 10.14739/2310-1210.2017.6.115313
Varynskyi, B. O. (2015). Optymіzatsіia umov detektuvannia riadu 1,2,4-trіazol-3-іl-tіoatsetatnykh kyslot ta yikh solei metodom VERH-ESІ-MS [Optimization of the detection conditions 1,2,4-triazol-3-yl-thioacetate acids series and their salts by HPLC-ESI-MS. Odeskyi medychnyi zhurnal, 4, 17–21. [in Ukrainian].
Varynskyi, B. O., Knysh, Ye. G., Parchenko, V. V., Panasenko, O. I., & Kaplaushenko, A. G. (2015). Vyvchennia zakonomіrnostei utrymuvannia potentsіinykh lіkarskykh substantsіi riadu 1,2,4-trіazol-3-іltіoatsetatnykh kyslot ta yikh solei metodom VERH /DMD-MS/ [The study of retention regularities for the potential drug substances of 1,2,4-triazol-3-ylthioacetic acids and their salts series by the method of HPLC/DAD-MS]. Zhurnal orhanichnoi ta farmatsevtychnoi khimii, 13(4), C. 68–72. [in Ukrainian].
(2009) Guideline on bioanalytical method validation. European Medicines Agency. Committee for Medicinal Products for Human Use (CHMP). London.
MOZ Ukrainy (2013) Validaciya bioanaliticheskogo metoda. [Validation of the bioanalytical method]. Kyiv. [in Russian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
