Development of the composition of the tablets "Cardiosten" using the method of mathematical planning of the experiment
DOI:
https://doi.org/10.14739/2409-2932.2019.2.170988Keywords:
tablets, plant extract, mathematical planning of the experiment, excipientsAbstract
The aim of the work is devoted to the substantiation of the choice of excipients while the development of Cardiosten tablets with a dry extract from a mixture of medicinal plant materials of cardiological action, taking into account the application of the mathematical planning of the experiment.
Materials and methods. Using the method of mathematical planning of the experiment (MPE), the influence of auxiliary substances on the technological properties of the granules with dry extract “Cardiosten” and tablets obtained from these granules was investigated. Fillers, sorbents (moisture regulators), structure-forming substances (disintegrating agents), binding substances and calcium stearate as a powdering agent (antifriction substance) were used as excipients. All groups of excipients (except calcium stearate) were divided into levels of factors, which were investigated by the four-factor experiment method based on a Greek-Latin square. The following indicators of granules and tablets based on dry extract “Cardiosen” were used as responses: bulk density g/cm3; mass flow for tableting, s/100g; mass loss during wetting and granulation, %; disintegration of tablets, min., abrasion of tablets, % and resistance of tablets to crushing, N.
Results. In the course of the conducted research, the dependence of all responses on the above factors was determined according to the technological parameters of the tablet mass and finished tablets.
Based on the analysis of the most effective levels of factors that had the maximum effect on the responses, the following substances were selected as further objects: Prosolv HD 90 (vehicle), Neosorb –100 (sorbent), polyplasdon XL10 (structuring agent) and HPMC solution as a binder.
Conclusions. Using the MPE method, the most optimal excipients were selected for the production of tablets with a dry extract content of “Cardiosten”. Based on the indicators of pelletized mass (bulk density, bulk flow, weight loss) and tablets (disintegration time of tablets, abrasion of tablets, resistance of tablets to crushing), the qualitative composition of auxiliary substances for the production of tablets by the method of wet granulation - Prosolv HD 90 (filler) was determined , Neosorb – 100 (sorbent), polyplasdon XL10 (structuring agent), HPMC solution (binding agent).
References
Kukhtenko, O. S., & Hladukh, E. V. (2014). Aktualnist rozrobky preparativ kardiotonichnoi dii na osnovi roslynnoi syrovyny [Urgency of development of preparations of cardiotonic action on the basis of plant material]. Farmakoekonomika v Ukraini: Stan ta perspektyvi rozvytku. Proceedings of the VІІ Scientific and Practical Internet Conference, (P. 133–134). Kharkiv. [in Ukrainian].
Kukhtenko, O. S., Simonyan, L. S. & Нladukh, Ye. V. (2017). Marketynhovi doslidzhennia rynku likarskykh zasobiv, shcho zastosovuiutsia pry likuvanni kardiolohichnykh zakhvoriuvan [Market research of medicinal products which are used in cardiological diseases treatment]. Current issues in pharmacy and medicine: science and practice, 10, 2(24), 219–223. [in Ukrainian]. doi: 10.14739/2409-2932.2017.2.103783
Zagayko, А. L., Kukhtenko, O. S., Galuzinska, L. V., & Hladukh, Ye. V. (2018). Doslidzhennia kardioprotektornykh vlastyvostei hustoho ekstraktu «Kardiocten» [Experimental study of cardioprotective properties of viscous extract “Cardiosten”]. Ukrainskyi biofarmatsevtychnyi zhurnal, 3(56), 30–33. [in Ukrainian]. https://doi.org/10.24959/ubphj.18.183
Hladukh, E. V., Ruban, O. A., Saiko, I. V., et al. (2016). Promyslova tekhnolohiia likarskykh zasobiv [Industrial technology of medicines]. Vinnytsia: Nova knyha. [in Ukrainian].
Hroshovyj, T. A., Martseniuk, V. P., Kucherenko, L. I., et al. (2008). Matematychne planuvannia eksperymentu pry provedenni naukovykh doslidzhen v farmatsii [Mathematical planning of the experiment in conducting scientific research in pharmacy]. Ternopil : Ukrmedknyha. [in Ukrainian].
Hureieva, S. M. (2013) Doslidzhennia farmako-tekhnolohichnykh i biofarmatsevtychnykh pokaznykiv yakosti tabletok amizonu [Investigation of pharmaco-technological and biopharmaceutical quality indices of amison tablets]. Farmakom, 2, 20–24. [in Ukrainian].
Beley, S. Ya., Hroshovyi, T. A., & Beley, N. M. (2018) Obgruntuvannia vyboru dopomizhnykh rechovyn dlia oderzhannia tabletok na osnovi ekstraktiv malvy lisovoi i podorozhnyka lantsetolystoho [Substantiation of selection of excipients for obtaining tablets based on malva sylvestris l. and plantago Lanceolata L. dry extracts]. Farmatsevtychnyi chasopys, 3. 37–44. [in Ukrainian]. doi: 10.11603/2312-0967.2018.3.9358
Derzhavne pidpryiemstvo «Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv» (2014) Derzhavna Farmakopeia Ukrainy [The state pharmacopoeia of Ukraine]. (Vol. 1). Kharkiv. [in Ukrainian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
