On dissolution test for Hypertril tablets using high performance liquid chromatography
DOI:
https://doi.org/10.14739/2409-2932.2019.1.158991Keywords:
hypertril, tablets, drug liberation, liquid high pressure chromatographyAbstract
Particular attention is paid to the release of the active ingredients of drugs in the form of tablets. Therefore, we have developed a method for determining the dissolution test, for the original drug Hypertril.
The purpose. To develop a methodology for dissolution test for Hypertril tablets with an active substance content of 20 mg using the HPLC method.
Materials and methods. In the studies we used Hypertril tablets with an active substance content of 20 mg, obtained in the Standardization and Drug Technology Laboratory at the Pharmaceutical Chemistry Department of ZSMU. A standard sample of the hypertril substance was received from the State Enterprise “Chemical Reagents Plant” (Kharkiv, Ukraine). We used high-performance liquid chromatograph Bishoff with an UV detector for studies. During the dissolution test of the Hypertril tablets, a device with a blade from the company Pharma Test PTWS 120D, Germany, was used.
Results. As a result of the conducted studies, the chromatograms were obtained. Having analyzed the chromatograms, we proved that the method is highly sensitive and accurate and can be used to determine the dissolution test. The obtained study results showed that the amount of the active substance that passed into the solution from the Hypertril tablets after 45 minutes and is from 91.2 to 99.6 %, that meets the requirements of the State Pharmacopoeia of Ukraine.
Conclusions. In the course of study, we developed a method for carrying out the dissolution test for Hypertril tablets with an active substance content of 20 mg using the HPLC method. The study results confirm that the developed method is accurate and reliable.
References
Siatynia, M. L., Popovych, V. P., & Nehoda, T. S. (2011) Doslidzhennia asortymentu antyhipertenzyvnykh likarskykh preparativ na farmatsevtychnomu rynku Ukrainy [Research of the range of antihypertensive drugs in the pharmaceutical market of Ukraine]. Current issues in pharmacy and medicine: science and practice, 24(1), 109–111. [in Ukrainian].
Kucherenko, L. l., Belenicbev, I. F., Parnyuk, N. V., & Subocheva, T. I. (2015) Galereya sovremennykh antianginal'nykh sredstv. Vzghlyad na novye preparaty [Thе gallery of modern antianginal drugs. A look аt new мedicines]. Edinyj vserosijskij nauchnyj vestnik, 1, 89–97. [in Russian].
Mazur, I. A., Bielenichev, I. F., Kucherenko, L. I., et al. (2014) (patentee) Patent 105618 Ukraina, MPK A61K 31/4196, A61P 9/10, A61P 25/00. Zastosuvannia bromidu 1-(ß-feniletyl)-4-amino-1,2,4-tryazoliiu yak aktyvnoi osnovy likarskykh zasobiv dlia korektsii porushen funktsionuvannia nitroksyderhichnoi systemy orhana-misheni – mozku pry hostrykh porushenniakh mozkovoho krovoobihu [Application of bromide 1-(ß-phenylethyl)-4-amino-1,2,4-triazolium as an active basis of drugs for correction of disturbances of the functioning of the nitroxydergic system of the target organ - the brain with acute cerebrovascular abnormalities]. [in Ukrainian].
Derzhavne pidpryiemstvo «Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv» (2014) Derzhavna Farmakopeia Ukrainy [The state pharmacopoeia of Ukraine]. (Vol. 1). Kharkiv. [in Ukrainian].
Kucherenko, L. I. (2015) Shchodo standartyzatsii substantsii Hipertrylu [On the standardization of Hypertril substance]. Farmatsevtychnyi chasopys, 2, 64–67. [in Ukrainian].
Parnyuk, N. V., Kucherenko, L .I., & Moryak, Z. B. (2015) Shchodo standartyzatsii tabletok antyhipertenzyvnoi dii [Regarding antihypertensive tablets standardization]. Current issues in pharmacy and medicine: science and practice, 3, 25–29. [in Ukrainian]. doi: https://doi.org/10.14739/2409-2932.2015.3.52619
Kucherenko, L. I., Parnyuk, N. V., & Moryak, Z. B. (2015). Rozrobka metodyky kilkisnoho vyznachennia dlia postadiinoho kontroliu vyrobnytstva tabletok «Hipertryl» [Development of quantitative determination methods for the stepwise control of «Hypertril» tablets production]. Farmatsevtychnyi chasopys, 2, 60–63. [in Ukrainian].
Sadek, P. (2009) Rastvoriteli dlia VE'ZhKh [HPLC solvents]. Moscow: Binom. Laboratoriya znanij. [in Russian].
Saprykin, L. V. (2006) Praktika i metodicheskie osnovy vysokoe'ffektivnoj zhidkostnoj khromatografii [Practice and methodological basis of high-performance liquid chromatography]. Krasnodar. [in Russian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
