“Sugar” tumor lung. Rare clinical case

Authors

  • A. I. Shevchenko Zaporizhzhia State Medical University, Ukraine,
  • Yu. O. Shatovskyi Zaporizhzhia Regional Pathoanatomical Bureau, Ukraine,
  • A. P. Melnychuk Zaporizhzhia State Medical University, Ukraine,
  • O. M. Andrianov Zaporizhzhia City Clinical Hospital № 10, Ukraine,

DOI:

https://doi.org/10.14739/2409-2932.2018.3.145266

Keywords:

clear-cell sugar tumors, lung

Abstract

Aim. Determination of the degree of malignancy and prognosis of the disease in patients with a “sugar” lung tumor.

Material and methods. The case of a light-cell (“sugar”) lung tumor in a 76-year-old patient is described and analyzed.

Results. The size and rate of growth of nodal formations in the lungs have a high correlation with the probability of their malignancy. The benign formations are either very small (less than 1 month in inflammatory processes), or very large (more than 16 months) time duplication of tumor mass. Lack of growth of a solid (dense) node within 2–3 years is a reliable criterion for its benign quality. The time to double the tumor mass of malignant tumors is usually in the range of 40 to 360 days. The time to double the tumor mass in this patient is 379 days.

Conclusion. The light-cell or “sugar” tumor is more likely to be a highly differentiated malignant tumor with a fairly prolonged time doubling of tumor mass than benign tumor. The low level of proliferative activity of the tumor, coexpress of vimentinum also indicates this.

 

 

References

Liebow, A. A., & Castleman, B. (1971). Benign clear cell ("sugar") tumors of the lung. Yale J Biol Med, 43(4–5), 213–222.

Kim, W. J., Kim, S. R., Choe, Y. H., Lee, K. Y., Park, S. J., Lee, H. S., et al. (2008). Clear Cell "Sugar" Tumor of the Lung: A Well-Enhanced Mass with an Early Washout Pattern on Dynamic Contrast-Enhanced Computed Tomography. Journal of Korean Medical Science, 23(6), 1121–1124. doi:10.3346/jkms.2008.23.6.1121.

Tsubochi, H., Sato, N., Hiyama, M., Kaimori, M., Endo, S., Sohara, Y., & Imai, T. (2006). Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer. Annals of Thoracic Surgery, 82(4), 1198–1204. doi:10.1016/j.athoracsur.2006.04.069.

Aragon, C. J., Sanchez, A. F., & Alarcon, J. P. (2005). Benign clear cell tumor of the lung. Archivos De Bronconeumologia, 41(1), 59–59.

Lu, Min, & Hu, Yongxiao. (2001). The Relationship Between Doubling Time of Lung Neoplasms and the Prognosis of Patients with Primary Lung Cancer. Journal of China Medical University, 1, 44–45.

Papla, B., Demczuk, S., & Malinowski, E. (2003). Benign clear-cell "sugar" tumor of the lung - a case report. Polish Journal of Pathology, 54(3), 183–185.

Oka, S., Uramoto, H., Shimokawa, H., Iwanami, T., & Tanaka, F. (2011). The expression of Ki-67, but not proliferating cell nuclear antigen, predicts poor disease free survival in patients with adenocarcinoma of the lung. Anticancer Research, 31(12), 4277–4282.

Khorouzhyk, S. A., Bogushevich, E. V., Sprindzhouk, M. V., & Snezhko, E. V., Kovalev, V. A., & Tuzikov, A. V. (2011). Komp'yuter-assistirovannaya diagnostika uzlovykh obrazovanij v legkih [Computer-aided diagnosis of the pulmonary nodules]. Voprosy onkologii, 57(1), 25–35. [in Russian].

Korman, D. B. (1989). Kharakteristika tempa rosta melkokletochnogo raka legkogo [Characterisation the rate of increase of small cell lung cancer]. Voprosy onkologii, 2, 158–163. [in Russian].

Marten, K., & Engelke, C. (2007). Computer-aided detection and automated CT volumetry of pulmonary nodules. European Radiology, 17(4), 888–901. doi:10.1007/s00330-006-0410-3.

Nathan, M. H., Collins, V. P., & Adams, R. A. (1962). Differentiation of benign and malignant pulmonary nodules by growth rate. Radiology, 79, 221–232.

Tan, B. B., Flaherty, K. R., Kazerooni, E. A., & Iannettoni, M. D. (2003). The solitary pulmonary nodule. Chest, 123(1), 89S–96S. doi:10.1378/chest.123.1_suppl.89S.

Yankelevitz, D. F., Gupta, R., Zhao, B., & Henschke, C. I. (1999). Small pulmonary nodules: Evaluation with repeat CT - Preliminary experience. Radiology, 212(2), 561–566. doi: 10.1148/radiology.212.2.r99au33561.

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How to Cite

Shevchenko, A. I., Shatovskyi, Y. O., Melnychuk, A. P., & Andrianov, O. M. (2018). “Sugar” tumor lung. Rare clinical case. Current Issues in Pharmacy and Medicine: Science and Practice, (3). https://doi.org/10.14739/2409-2932.2018.3.145266

Issue

No. 3 (2018)

Section

Case Reports

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