“Sugar” tumor lung. Rare clinical case
Keywords:clear-cell sugar tumors, lung
Aim. Determination of the degree of malignancy and prognosis of the disease in patients with a “sugar” lung tumor.
Material and methods. The case of a light-cell (“sugar”) lung tumor in a 76-year-old patient is described and analyzed.
Results. The size and rate of growth of nodal formations in the lungs have a high correlation with the probability of their malignancy. The benign formations are either very small (less than 1 month in inflammatory processes), or very large (more than 16 months) time duplication of tumor mass. Lack of growth of a solid (dense) node within 2–3 years is a reliable criterion for its benign quality. The time to double the tumor mass of malignant tumors is usually in the range of 40 to 360 days. The time to double the tumor mass in this patient is 379 days.
Conclusion. The light-cell or “sugar” tumor is more likely to be a highly differentiated malignant tumor with a fairly prolonged time doubling of tumor mass than benign tumor. The low level of proliferative activity of the tumor, coexpress of vimentinum also indicates this.
Liebow, A. A., & Castleman, B. (1971). Benign clear cell ("sugar") tumors of the lung. Yale J Biol Med, 43(4–5), 213–222.
Kim, W. J., Kim, S. R., Choe, Y. H., Lee, K. Y., Park, S. J., Lee, H. S., et al. (2008). Clear Cell "Sugar" Tumor of the Lung: A Well-Enhanced Mass with an Early Washout Pattern on Dynamic Contrast-Enhanced Computed Tomography. Journal of Korean Medical Science, 23(6), 1121–1124. doi:10.3346/jkms.2008.23.6.1121.
Tsubochi, H., Sato, N., Hiyama, M., Kaimori, M., Endo, S., Sohara, Y., & Imai, T. (2006). Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer. Annals of Thoracic Surgery, 82(4), 1198–1204. doi:10.1016/j.athoracsur.2006.04.069.
Aragon, C. J., Sanchez, A. F., & Alarcon, J. P. (2005). Benign clear cell tumor of the lung. Archivos De Bronconeumologia, 41(1), 59–59.
Lu, Min, & Hu, Yongxiao. (2001). The Relationship Between Doubling Time of Lung Neoplasms and the Prognosis of Patients with Primary Lung Cancer. Journal of China Medical University, 1, 44–45.
Papla, B., Demczuk, S., & Malinowski, E. (2003). Benign clear-cell "sugar" tumor of the lung - a case report. Polish Journal of Pathology, 54(3), 183–185.
Oka, S., Uramoto, H., Shimokawa, H., Iwanami, T., & Tanaka, F. (2011). The expression of Ki-67, but not proliferating cell nuclear antigen, predicts poor disease free survival in patients with adenocarcinoma of the lung. Anticancer Research, 31(12), 4277–4282.
Khorouzhyk, S. A., Bogushevich, E. V., Sprindzhouk, M. V., & Snezhko, E. V., Kovalev, V. A., & Tuzikov, A. V. (2011). Komp'yuter-assistirovannaya diagnostika uzlovykh obrazovanij v legkih [Computer-aided diagnosis of the pulmonary nodules]. Voprosy onkologii, 57(1), 25–35. [in Russian].
Korman, D. B. (1989). Kharakteristika tempa rosta melkokletochnogo raka legkogo [Characterisation the rate of increase of small cell lung cancer]. Voprosy onkologii, 2, 158–163. [in Russian].
Marten, K., & Engelke, C. (2007). Computer-aided detection and automated CT volumetry of pulmonary nodules. European Radiology, 17(4), 888–901. doi:10.1007/s00330-006-0410-3.
Nathan, M. H., Collins, V. P., & Adams, R. A. (1962). Differentiation of benign and malignant pulmonary nodules by growth rate. Radiology, 79, 221–232.
Tan, B. B., Flaherty, K. R., Kazerooni, E. A., & Iannettoni, M. D. (2003). The solitary pulmonary nodule. Chest, 123(1), 89S–96S. doi:10.1378/chest.123.1_suppl.89S.
Yankelevitz, D. F., Gupta, R., Zhao, B., & Henschke, C. I. (1999). Small pulmonary nodules: Evaluation with repeat CT - Preliminary experience. Radiology, 212(2), 561–566. doi: 10.1148/radiology.212.2.r99au33561.
How to Cite
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)