Investigation of excipients’ nature influence on the quality indices of effervescent tablets of acetylsalicylic acid, paracetamol and ascorbic acid
DOI:
https://doi.org/10.14739/2409-2932.2018.1.123712Keywords:
tablets, excipients, pharmaco-technological parameters, variance analysisAbstract
The priority objective of pharmaceutical science remains the creation and rational use of medicines. In recent years among these medicines particular attention is paid to the form of sparkling (fast-dissolving, gaseous or effervescent) solid dosage forms – tablets, granules, powders, microspheres, capsules, suppositories and others. In the development of effervescent tablets, which are absent in the domestic market, a combination of acetylsalicylic acid, paracetamol and ascorbic acid was selected for experimental studies.
The purpose of the work is to study the influence of excipients on the pharmaco-technological properties of effervescent tablets of acetylsalicylic acid, paracetamol and ascorbic acid.
Materials and methods. In the course of the experiment, nine excipients from groups of fillers, leavens and binders were investigated. By studying qualitative factors, one of the plans of dispersion analysis was used, namely a three-factorial experiment based on the Hyper-Greek-Latin square. In experiments we used modern equipment for determining the bulk density of powders (ERWEKA GT, Germany), bulk density (ERWEKA SVM 202, Germany), tablet press (Korsh XL-100, Germany), uniformity of the weight of tablets (Mettler Toledo AB54-S, Switzerland), crushing resistance (ERWEKA TBH-525 WTO, Germany), abradability (ERWEKA TAR 200, Germany), disintegration time (ERWEKA ZT 33, Germany).
Results. As a result of the statistical processing of experimental results, the influence of excipients on the pharmaco-technological parameters of mass for tableting (bulk density, density after compression, Carr's index, flow ability, slope angle), tableting process, tablet appearance, mass uniformity, abradability, resistance to crushing, disintegration and transparency of the solution were investigated.
Conclusions. The influence of nine excipients on the pharmaco-technological characteristics of effervescent tablets of acetylsalicylic acid, paracetamol and ascorbic acid was studied. One-dimensional leaders for most of the investigated pharmaco-technological parameters are anhydrous lactose (SuperTab® 22AN), crospovidone XL-10, sodium stearyl fumarate (Pruv®). The obtained results are the basis for the development of the optimal composition of effervescent tablets of acetylsalicylic acid, paracetamol and ascorbic acid.
References
Ganesh M. Bajaj, Ajit Kalyankar, Ashok Bhosale, Sharwaree Hardikar, Abijeet Khopade (2014). A review: revisit with decade of progrss on challenges for development of dispersible tablet. Indo American Journal of Pharmaceutical Research, 4(6), 2672–2681.
Trygubchak, O. V., & Groshovy, T. A. (2015) Izucheniya farmako-tekhnologicheskikh svojstv produktov Sorb-Cel® dlya sozdaniya shipuchikh tabletok acetilsalicilovoj kisloty [Study of pharmaco-technological properties of products Sorb-Cel® for creating of effervescent tablets based on acetylsalicylic acid]. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya Medicina. Farmaciya, 22(219), 32, 191–199. [in Russian].
Yurieva, O. O., Hureieva, C. M., & Tryhubchak, O. V. (2017) Vplyv dopomizhnykh rechovyn na farmako-tekhnolohichni vlastyvosti tabletok [Influence of excipients on the pharmaco-technological properties of tablets]. Pivdennoukrainskyi medychnyi naukovyi zhurnal, 17, 91–95. [in Ukrainian].
Tryhubchak, O. V. (2014) Marketynhovi doslidzhennia rynku shypuchykh tabletok [Marketing researches of effervescent tablets market]. Zdobutky eksperymentalnoi i klinichnoi medytsyny, 2(21), 22–25. [in Ukrainian].
Suñé-Negre, J. M., Roig, M., Fuster, R., Hernández, C., Ruhí, R., García-Montoya, E., et al. (2014) New classification of directly compressible (DC) excipients in function of the SeDeM Diagarm Expert System. International Journal of Pharmaceutics, 470, 15–27. doi: 10.1016/j.ijpharm.2014.04.068.
Yezhned, M. A., Тryhubchak, O. V., & Hroshovyi, T. A. (2015) Suchasnyі stan stvorennіa, vyrobnytstva ta doslidzhennіa tabletovanykh likarskykh preparativ. Povidomlennіa 18. Osoblyvosti zastosuvannіa ta kharakterystyka dezintehratoriv pry vyrobnytstvi tabletok [Modern state of creation, production and research of tablet drugs]. Farmatsevtychnyi chasopys, 2(34), 130–135. [in Ukrainian]. doi: 10.11603/2312-0967.2015.2.4799.
Hroshovyi, T. A., Martseniuk, V. P., & Kucherenko, L. І. (2008) Matematychne planuvannia eksperymentu pry provedennі naukovyh doslіdzhen v farmatsіi [Mathematical experiment planning at research in pharmacy]. Ternopіl: Ukrmedknyha. [in Ukrainian].
Derzhavne pidpryiemstvo «Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv» (2016) Derzhavna Farmakopeia Ukrainy [The state pharmacopeia of Ukraine]. Kharkiv [in Ukrainian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
